Protein: VGFR2
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)

Gene: VGFR2, KDR
Organism: Homo sapiens
Interactions: 148
UniProt ID: P35968

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001541 - ovarian follicle development
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001934 - positive regulation of protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549560

VEGFA
Vascular endothelial growth factor A, long form

19

20

Small-scale

0.988

High

729618

VGFR2
Vascular endothelial growth factor receptor 2

7

17

Small-scale

0.958

High

522825

SRC
Proto-oncogene tyrosine-protein kinase Src

6

20

Small-scale

0.937

High

155288

NRP1
Neuropilin-1

6

9

Small-scale

0.931

High

665808

PTN6
Tyrosine-protein phosphatase non-receptor type 6

4

20

Small-scale

0.888

High

729640

SHC2
SHC-transforming protein 2

3

20

Small-scale

0.880

High

729626

VEGFC
Vascular endothelial growth factor C

2

20

Small-scale

0.845

High

729641

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

2

14

Small-scale

0.831

High

666023

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.830

High

729237

VGFR3
Vascular endothelial growth factor receptor 3

3

17

Small-scale

0.827

High

729644

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.826

High

729624

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

12

Small-scale

0.819

High

557625

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.789

High

572590

VGFR1
Vascular endothelial growth factor receptor 1

2

17

Small-scale

0.768

High

729647

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

19

Small-scale

0.761

High

580949

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

19

Small-scale

0.755

High

729636

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.754

High

729625

KC1D
Casein kinase I isoform delta

1

1

Small-scale

0.724

High

729643

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.698

High

729658

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

729659

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.691

High

729675

PALLD
Palladin

1

20

High-throughput

0.691

High

729692

SH22A
SH2 domain-containing protein 2A

1

20

Small-scale

0.681

High

217379

VEGFD
Vascular endothelial growth factor D

1

20

Small-scale

0.647

High

615386

KALM
Anosmin-1

1

13

Small-scale

0.647

High

658817

MK01
Mitogen-activated protein kinase 1

1

9

Small-scale

0.647

High

702746

CADH5
Cadherin-5

3

8

Small-scale

0.643

High

394228

A4
Amyloid-beta precursor protein

2

5

Small-scale

0.629

High

729650

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.621

High

729633

1433G
14-3-3 protein gamma

1

14

High-throughput

0.618

High

412060

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

441451

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.618

High

452365

PGFRB
Platelet-derived growth factor receptor beta

1

18

Small-scale

0.618

High

596365

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.618

High

729621

STAT3
Signal transducer and activator of transcription 3

1

13

Small-scale

0.618

High

729622

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

13

Small-scale

0.618

High

729628

DYN2
Dynamin-2

1

10

Small-scale

0.618

High

729700

PLXA1
Plexin-A1

1

13

Small-scale

0.618

High

729706

PLXD1
Plexin-D1

1

15

Small-scale

0.618

High

729701

FBW1B
F-box/WD repeat-containing protein 11

2

8

Small-scale

0.600

High

610266

CBL
E3 ubiquitin-protein ligase CBL

2

20

Small-scale

0.595

High

729704

FBW1A
F-box/WD repeat-containing protein 1A

2

8

Small-scale

0.590

High

236853

GREM1
Gremlin-1

1

2

Small-scale

0.578

High

449211

LEG1
Galectin-1

1

6

Small-scale

0.578

High

403808

ITB1
Integrin beta-1

2

9

Small-scale

0.571

High

306000

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

Small-scale

0.552

High

273384

PPM1B
Protein phosphatase 1B

1

6

High-throughput

0.541

High

728586

PPM1A
Protein phosphatase 1A

1

6

High-throughput

0.541

High

729673

DUS19
Dual specificity protein phosphatase 19

1

13

High-throughput

0.541

High

729674

STYX
Serine/threonine/tyrosine-interacting protein

1

13

High-throughput

0.541

High

729688

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

12

High-throughput

0.541

High

259705

PDCD6
Programmed cell death protein 6

1

2

Small-scale

0.529

High

444850

ANXA5
Annexin A5

1

1

Small-scale

0.527

High

499579

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.515

High

636825

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.515

High

212038

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.513

High

729665

NNRD
ATP-dependent

1

0

High-throughput

0.513

High

729649

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.508

High

729619

PEDF
Pigment epithelium-derived factor

1

7

Small-scale

0.501

High

729620

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

2

Small-scale

0.501

High

729639

HTRA4
Serine protease HTRA4

1

4

Small-scale

0.501

High

729660

GRDN
Girdin

1

5

Small-scale

0.501

High

729670

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

729677

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.501

High

729689

PDCL3
Phosducin-like protein 3

1

2

Small-scale

0.501

High

229326

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

7

High-throughput

0.479

High

260778

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.479

High

396572

ITB3
Integrin beta-3

1

9

Small-scale

0.479

High

423164

PDIA1
Protein disulfide-isomerase

1

12

Small-scale

0.479

High

431596

HS90A
Heat shock protein HSP 90-alpha

1

18

Small-scale

0.479

High

443046

ITA5
Integrin alpha-5

1

6

Small-scale

0.479

High

475421

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

566858

ITA2
Integrin alpha-2

1

6

Small-scale

0.479

High

575701

VINC
Vinculin

1

5

Small-scale

0.479

High

577592

SON
Protein SON

1

5

High-throughput

0.479

High

592129

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.479

High

658635

SMCA1
Probable global transcription activator SNF2L1

1

7

High-throughput

0.479

High

701705

IL3RB
Cytokine receptor common subunit beta

1

9

Small-scale

0.479

High

729623

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.479

High

729627

EMD
Emerin

1

6

High-throughput

0.479

High

729629

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

6

Small-scale

0.479

High

729630

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

Small-scale

0.479

High

729631

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

High-throughput

0.479

High

729632

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.479

High

729634

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

2

High-throughput

0.479

High

729635

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

Small-scale

0.479

High

729637

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

High-throughput

0.479

High

729642

ATP7A
Copper-transporting ATPase 1

1

1

Small-scale

0.479

High

729646

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

5

High-throughput

0.479

High

729651

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

729652

TRA2A
Transformer-2 protein homolog alpha

1

1

High-throughput

0.479

High

729653

PWP1
Periodic tryptophan protein 1 homolog

1

8

High-throughput

0.479

High

729654

CUL1
Cullin-1

1

3

Small-scale

0.479

High

729655

NCOA4
Nuclear receptor coactivator 4

1

1

High-throughput

0.479

High

729656

LRP8
Low-density lipoprotein receptor-related protein 8

1

5

Small-scale

0.479

High

729657

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.479

High

729663

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.479

High

729664

AHNK2
Protein AHNAK2

1

3

High-throughput

0.479

High

729666

GCC2
GRIP and coiled-coil domain-containing protein 2

1

4

High-throughput

0.479

High

729667

PHF6
PHD finger protein 6

1

5

High-throughput

0.479

High

729669

ZN397
Zinc finger protein 397

1

3

High-throughput

0.479

High

729671

DDX54
ATP-dependent RNA helicase DDX54

1

14

High-throughput

0.479

High

729672

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

6

High-throughput

0.479

High

729678

TNR25
Tumor necrosis factor receptor superfamily member 25

1

10

Small-scale

0.479

High

729680

DDX27
Probable ATP-dependent RNA helicase DDX27

1

14

High-throughput

0.479

High

729681

ZFP3
Zinc finger protein 3 homolog

1

1

High-throughput

0.479

High

729682

RBM14
RNA-binding protein 14

1

7

High-throughput

0.479

High

729683

RBM15
RNA-binding protein 15

1

3

High-throughput

0.479

High

729684

MINT
Msx2-interacting protein

1

3

High-throughput

0.479

High

729687

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

729693

SCUB2
Signal peptide, CUB and EGF-like domain-containing protein 2

1

3

Small-scale

0.479

High

729694

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

12

High-throughput

0.479

High

729695

MDN1
Midasin

1

8

High-throughput

0.479

High

729696

SEC63
Translocation protein SEC63 homolog

1

13

High-throughput

0.479

High

729698

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

17

High-throughput

0.479

High

729699

BAZ1B
Tyrosine-protein kinase BAZ1B

1

9

High-throughput

0.479

High

729702

RALY
RNA-binding protein Raly

1

1

High-throughput

0.479

High

729703

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

3

High-throughput

0.479

High

729707

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

3

High-throughput

0.479

High

729708

SP16H
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

729709

EPN1
Epsin-1

1

11

Small-scale

0.479

High

417992

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

508843

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

583406

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

729648

GNDS
Ral guanine nucleotide dissociation stimulator

1

3

Small-scale

0.445

High

729691

ANTR1
Anthrax toxin receptor 1

1

5

Small-scale

0.445

High

273707

NU155
Nuclear pore complex protein Nup155

1

6

High-throughput

0.437

High

451854

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

5

High-throughput

0.437

High

588846

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

5

High-throughput

0.437

High

729638

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.437

High

729662

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.437

High

729668

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.437

High

729676

NU205
Nuclear pore complex protein Nup205

1

7

High-throughput

0.437

High

729685

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.437

High

729686

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.437

High

729690

TXNIP
Thioredoxin-interacting protein

1

4

Small-scale

0.437

High

729697

IPO11
Importin-11

1

3

High-throughput

0.437

High

729705

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

56449

A2A2Q9
Protein AAR2 homolog

1

2

High-throughput

0.407

High

72786

B4DF87
Nuclear receptor coactivator 4

1

1

High-throughput

0.407

High

102370

G3V1M0
Uncharacterized protein DKFZp686H10254

1

5

High-throughput

0.407

High

134840

IMA3
Importin subunit alpha-3

1

0

High-throughput

0.391

High

729661

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.279

Low

729645

QOR
Quinone oxidoreductase

1

0

High-throughput

0.261

Low

623722

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

Small-scale

0.251

Low

256471

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.249

Low

729679

MSI2H
RNA-binding protein Musashi homolog 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024