Protein: ACTN
Alpha-actinin, sarcomeric (F-actin cross-linking protein)

Gene: ACTN
Organism: Drosophila melanogaster
Interactions: 95
UniProt ID: P18091

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0030018 - Z disc

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

56341

ZASP
PDZ and LIM domain protein Zasp

5

20

Small-scale

0.910

High

432166

MYSA
Myosin heavy chain, muscle

2

10

High-throughput

0.737

High

446262

MLC1
Myosin light chain alkali

2

4

High-throughput

0.737

High

612364

TNNC1
Troponin C, isoform 1

2

4

High-throughput

0.737

High

612373

MLP2
Muscle LIM protein Mlp84B

1

14

Small-scale

0.713

High

387027

ACT4
Actin, larval muscle

2

17

High-throughput

0.659

High

612426

Q9W4T9
Kin of irre, isoform A

1

12

Small-scale

0.621

High

612386

LASP1
LIM and SH3 domain protein Lasp

1

13

Small-scale

0.618

High

612394

Q95TZ7
GH19182p

2

20

Small-scale

0.586

High

571700

MP20
Muscle-specific protein 20

1

7

High-throughput

0.575

High

612368

CALM
Calmodulin

1

3

High-throughput

0.575

High

612371

MY61F
Unconventional myosin IC

1

14

High-throughput

0.575

High

612379

Q71JA7
Nesprin

1

19

High-throughput

0.575

High

612381

Q7K569
Glycerol-3-phosphate dehydrogenase

1

5

High-throughput

0.575

High

612382

Q7KQP6
Bent, isoform C

1

20

High-throughput

0.575

High

612402

FLNA
Filamin-A

1

16

High-throughput

0.575

High

482725

TPM2
Tropomyosin-2

2

3

High-throughput

0.571

High

612356

MLR
Myosin regulatory light chain 2

2

6

High-throughput

0.571

High

612357

TNNT
Troponin T, skeletal muscle

2

2

High-throughput

0.571

High

612363

MOEH
Moesin/ezrin/radixin homolog 1

2

13

High-throughput

0.562

High

612387

Q8IQB4
Z band alternatively spliced PDZ-motif protein 66, isoform E

2

1

High-throughput

0.562

High

459981

ALF
Fructose-bisphosphate aldolase

2

0

High-throughput

0.547

High

567539

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

2

0

High-throughput

0.547

High

612362

TNNI
Troponin I

2

0

High-throughput

0.547

High

612365

KARG
Arginine kinase 1

2

0

High-throughput

0.547

High

612389

Q8MSI2
GH15296p

2

0

High-throughput

0.547

High

612417

SMN
Survival motor neuron protein

1

0

Small-scale

0.537

High

612360

MYSP2
Paramyosin, short form

2

11

High-throughput

0.521

High

612405

Q9VIE8
Aconitate hydratase, mitochondrial

2

2

High-throughput

0.521

High

534344

ACT5
Actin-87E

1

17

High-throughput

0.514

High

612367

TBB2
Tubulin beta-2 chain

1

1

High-throughput

0.514

High

612406

SICK
Protein sickie

1

16

Small-scale

0.514

High

612395

HRS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

High-throughput

0.494

High

612418

Q9VVA7
Tumor suppressor protein 101

1

5

High-throughput

0.494

High

612396

TITIN
Titin

1

20

High-throughput

0.492

High

120045

M9PC91
Rolling pebbles, isoform I

1

13

Small-scale

0.481

High

119509

M9NHC5
Uncharacterized protein, isoform C

1

11

High-throughput

0.479

High

612409

RHEB
GTP-binding protein Rheb homolog

1

5

High-throughput

0.479

High

612423

DOS
Protein daughter of sevenless

1

15

High-throughput

0.479

High

612397

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.464

High

262722

TENM
Teneurin-m

1

4

High-throughput

0.445

High

538201

HSP7B
Heat shock 70 kDa protein cognate 2

1

3

High-throughput

0.445

High

564945

ATNA
Sodium/potassium-transporting ATPase subunit alpha

1

1

High-throughput

0.445

High

578025

ENO
Enolase

1

1

High-throughput

0.445

High

612372

SEM2A
Semaphorin-2A

1

1

High-throughput

0.445

High

612403

TWF
Twinfilin

1

1

High-throughput

0.445

High

612419

Q9VWG1
LD37169p

1

11

High-throughput

0.445

High

95393

E1JJ90
Meiosis-specific nuclear structural protein 1

1

3

High-throughput

0.439

High

68700

A8JQV1
Uncharacterized protein, isoform C

1

4

High-throughput

0.437

High

612359

OSKA
Maternal effect protein oskar

1

1

Small-scale

0.437

High

612388

Q8IQQ0
2-oxoglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

612420

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

458035

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

0

High-throughput

0.426

High

612361

FTN
Flightin

1

0

High-throughput

0.426

High

612376

Q59DP9
Calcium-transporting ATPase

1

0

High-throughput

0.426

High

612385

Q8I0D4
RE20510p

1

0

High-throughput

0.426

High

612404

Q9VHR7
Meiosis-specific nuclear structural protein 1

1

3

High-throughput

0.417

High

68040

A8DRW0
Cuticular protein 49Aa

1

2

High-throughput

0.407

High

87082

Y5076
Uncharacterized protein CG45076

1

19

High-throughput

0.407

High

87145

FAU
Protein anoxia up-regulated

1

1

High-throughput

0.407

High

612370

P91941
Adult cuticle protein 65Aa

1

2

High-throughput

0.407

High

612374

ATPO
ATP synthase subunit O, mitochondrial

1

4

High-throughput

0.407

High

612375

Q4V467
IP10845p

1

4

High-throughput

0.407

High

612393

Q95RB2
Cuticular protein 49Ae

1

2

High-throughput

0.407

High

612399

INO80
Chromatin-remodeling ATPase INO80

1

4

High-throughput

0.407

High

612413

Q9VSA9
CG7409

1

11

High-throughput

0.407

High

612422

Q9VYK0
Smrter, isoform D

1

9

High-throughput

0.407

High

612427

FL2D
Pre-mRNA-splicing regulator female-lethal(2)D

1

5

High-throughput

0.407

High

358460

ADH
Alcohol dehydrogenase

2

0

High-throughput

0.298

High

612366

DHE3
Glutamate dehydrogenase, mitochondrial

2

0

High-throughput

0.298

High

612384

Q8I062
GH23305p

2

0

High-throughput

0.298

High

612400

Q9VEB1
Malate dehydrogenase, mitochondrial

2

0

High-throughput

0.298

High

612401

Q9VED1
IP07781p

2

0

High-throughput

0.298

High

612407

Q9VM18
Trehalose 6-phosphate phosphatase

2

0

High-throughput

0.298

High

612412

Q9VRL0
Cytochrome c1, heme protein, mitochondrial

2

0

High-throughput

0.298

High

612425

CISY
Probable citrate synthase, mitochondrial

2

0

High-throughput

0.298

High

612414

EXOC7
Exocyst complex component 7

1

0

High-throughput

0.282

High

612378

Q6NQZ7
LD40663p

1

0

High-throughput

0.265

Low

612411

ELBA3
Early boundary activity protein 3

1

0

High-throughput

0.265

Low

612410

Q9VQR2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.249

Low

68658

BL1S3
Biogenesis of lysosome-related organelles complex 1 subunit 3

1

0

High-throughput

0.232

Low

612358

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.232

Low

612369

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

612377

Q6IHY5
Cytochrome c oxidase subunit 7A-like 2, isoform A

1

0

High-throughput

0.232

Low

612380

Q7JUS9
Phosphate carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

612383

RS15B
Small ribosomal subunit protein uS8B

1

0

High-throughput

0.232

Low

612390

Q8STG9
DSec61alpha

1

0

High-throughput

0.232

Low

612391

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.232

Low

612392

AT5F1
ATP synthase subunit b, mitochondrial

1

0

High-throughput

0.232

Low

612398

Q9V9U0
RE35358p

1

0

High-throughput

0.232

Low

612408

Q9VMR2
LP04777p

1

0

High-throughput

0.232

Low

612415

Q9VSY0
Cuticular protein 67B

1

0

High-throughput

0.232

Low

612416

NPLP2
Neuropeptide-like 2

1

0

High-throughput

0.232

Low

612421

SUN
Protein stunted

1

0

High-throughput

0.232

Low

612424

ATPK
Putative ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025