Protein: ERG13
Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)

Gene: ERG13
Organism: Saccharomyces cerevisiae S288C
Interactions: 68
UniProt ID: P54839

Gene Ontology (top 5):
GO:0004421 - hydroxymethylglutaryl-CoA synthase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006084 - acetyl-CoA metabolic process
GO:0006696 - ergosterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

732115

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

2

0

High-throughput

0.595

High

492107

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.571

High

774657

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

0

High-throughput

0.563

High

873207

ACT
Actin

2

0

High-throughput

0.563

High

797520

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

494691

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

512333

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

695289

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.552

High

769163

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

873210

RUVB1
RuvB-like protein 1

2

0

High-throughput

0.547

High

593173

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.518

High

618855

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

368308

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.513

High

479515

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.513

High

873208

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

555760

THRC
Threonine synthase

1

0

High-throughput

0.493

High

404668

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.489

High

873209

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

366721

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

544232

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

407239

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

558193

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

628351

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

663019

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

664991

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

680920

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

688368

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

691098

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

703708

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

753910

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

757001

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

774993

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

860562

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

864133

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

873212

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

873213

SGO1
Shugoshin

1

0

High-throughput

0.458

High

873215

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

873216

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

873218

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.458

High

560764

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

588188

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

424659

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

499032

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

556226

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

873217

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.407

High

498571

METK1
S-adenosylmethionine synthase 1

2

0

High-throughput

0.307

High

866229

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

2

0

High-throughput

0.307

High

382786

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.279

Low

383290

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.279

Low

405251

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.279

Low

471193

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.279

Low

534822

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

770436

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.279

Low

873211

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

873219

RS25A
Small ribosomal subunit protein eS25A

1

0

High-throughput

0.279

Low

426092

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

482917

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

632026

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

730060

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

745813

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

752601

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

811199

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

873214

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

360989

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

687454

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

700564

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

784196

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low

785157

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024