Protein: IL6
Interleukin-6 (IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)

Gene: IL6
Organism: Mus musculus
Interactions: 20
UniProt ID: P08505

Gene Ontology (top 5):
GO:0001781 - neutrophil apoptotic process
GO:0002262 - myeloid cell homeostasis
GO:0002314 - germinal center B cell differentiation
GO:0002639 - positive regulation of immunoglobulin production
GO:0005125 - cytokine activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

470400

TF65
Transcription factor p65

11

4

Small-scale

0.751

High

470399

IL6RB
Interleukin-6 receptor subunit beta

1

1

Small-scale

0.646

High

470392

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

6

Small-scale

0.640

High

470406

IKBZ
NF-kappa-B inhibitor zeta

3

3

Small-scale

0.640

High

470403

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

2

Small-scale

0.584

High

470395

CEBPG
CCAAT/enhancer-binding protein gamma

2

4

Small-scale

0.533

High

148637

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

432047

JUN
Transcription factor Jun

1

1

Small-scale

0.479

High

470391

JUNB
Transcription factor JunB

1

2

Small-scale

0.479

High

470393

CEBPB
CCAAT/enhancer-binding protein beta

1

4

Small-scale

0.479

High

470397

HDAC2
Histone deacetylase 2

1

1

Small-scale

0.479

High

470401

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

470405

1433B
14-3-3 protein beta/alpha

1

1

Small-scale

0.479

High

470407

IKBA
NF-kappa-B inhibitor alpha

1

3

Small-scale

0.479

High

204815

XBP1
X-box-binding protein 1

1

0

Small-scale

0.458

High

470394

BCL6
B-cell lymphoma 6 protein homolog

1

0

Small-scale

0.458

High

470396

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

1

Small-scale

0.437

High

470398

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.249

Low

470402

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

0

Small-scale

0.249

Low

470404

ZFP64
Zinc finger protein 64

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025