Protein: ERG6
Sterol 24-C-methyltransferase ERG6 (SCMT) (EC 2.1.1.41) (Delta(24)-sterol C-methyltransferase ERG6) (Ergosterol biosynthetic protein 6)

Gene: ERG6
Organism: Saccharomyces cerevisiae S288C
Interactions: 106
UniProt ID: P25087

Gene Ontology (top 5):
GO:0003838 - sterol 24-C-methyltransferase activity
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005811 - lipid droplet

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

626410

ERG6
Sterol 24-C-methyltransferase ERG6

4

8

Small-scale

0.887

High

626448

ERG28
Ergosterol biosynthetic protein 28

3

0

Small-scale

0.653

High

626457

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

626499

OSH2
Oxysterol-binding protein homolog 2

1

2

Small-scale

0.573

High

493265

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.571

High

490421

HSP71
Heat shock protein SSA1

3

5

High-throughput

0.569

High

495792

CP51
Lanosterol 14-alpha demethylase CYP51

1

1

Small-scale

0.541

High

626412

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

626418

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

Small-scale

0.541

High

626419

ERG24
Delta(14)-sterol reductase ERG24

1

1

Small-scale

0.541

High

626466

ERG25
C-4 methylsterol oxidase ERG25

1

1

Small-scale

0.541

High

626475

ERG5
C-22 sterol desaturase ERG5

1

1

Small-scale

0.541

High

626484

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.536

High

510352

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.521

High

626415

ERG9
Squalene synthase ERG9

1

0

Small-scale

0.518

High

626417

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.518

High

626437

ERG7
Lanosterol synthase ERG7

1

0

Small-scale

0.518

High

626446

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

626458

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.518

High

626469

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

Small-scale

0.518

High

626500

ERG27
3-keto-steroid reductase ERG27

1

0

Small-scale

0.518

High

626483

MYO5
Myosin-5

1

3

Small-scale

0.504

High

541940

MTF1
Mitochondrial transcription factor 1

1

0

High-throughput

0.493

High

626449

IMB4
Importin subunit beta-4

1

1

Small-scale

0.489

High

626413

MSP1
Outer mitochondrial transmembrane helix translocase

1

3

High-throughput

0.481

High

626416

OAC1
Mitochondrial oxaloacetate transport protein

1

2

High-throughput

0.481

High

626421

TOR2
Serine/threonine-protein kinase TOR2

1

3

High-throughput

0.481

High

626430

MCR1
NADH-cytochrome b5 reductase 2

1

2

High-throughput

0.481

High

626438

NCB5R
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.481

High

626439

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

2

High-throughput

0.481

High

626441

TOM71
Protein TOM71

1

3

High-throughput

0.481

High

626442

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.481

High

626444

PET8
Putative mitochondrial carrier protein PET8

1

1

High-throughput

0.481

High

626451

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

1

High-throughput

0.481

High

626454

DJP1
DnaJ-like protein 1

1

6

High-throughput

0.481

High

626460

MDV1
Mitochondrial division protein 1

1

3

High-throughput

0.481

High

626470

PEX31
Peroxisomal membrane protein PEX31

1

1

High-throughput

0.481

High

626472

DSL1
Protein transport protein DSL1

1

1

High-throughput

0.481

High

626489

DIC1
Mitochondrial dicarboxylate transporter

1

2

High-throughput

0.481

High

626490

PEX30
Peroxisomal membrane protein PEX30

1

1

High-throughput

0.481

High

543248

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

626431

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

626440

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

626486

RTN1
Reticulon-like protein 1

1

1

Small-scale

0.479

High

626488

BSC2
Bypass of stop codon protein 2

1

1

Small-scale

0.479

High

626501

SMC6
Structural maintenance of chromosomes protein 6

1

5

High-throughput

0.479

High

486434

COX7
Cytochrome c oxidase subunit 7, mitochondrial

1

0

High-throughput

0.460

High

534368

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.460

High

606798

QCR9
Cytochrome b-c1 complex subunit 9, mitochondrial

1

0

High-throughput

0.460

High

626423

SC61A
Protein transport protein SEC61

1

0

Small-scale

0.460

High

626425

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

Small-scale

0.460

High

626426

PTH2
Peptidyl-tRNA hydrolase 2

1

0

High-throughput

0.460

High

626432

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.460

High

626436

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.460

High

626447

FMP52
Protein FMP52, mitochondrial

1

0

High-throughput

0.460

High

626452

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.460

High

626455

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.460

High

626461

IML2
Inclusion body clearance protein IML2

1

0

High-throughput

0.460

High

626462

TIM54
Mitochondrial import inner membrane translocase subunit TIM54

1

0

High-throughput

0.460

High

626465

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.460

High

626467

MDM34
Mitochondrial distribution and morphology protein 34

1

0

High-throughput

0.460

High

626468

GET1
Golgi to ER traffic protein 1

1

0

High-throughput

0.460

High

626473

FOL1
Folic acid synthesis protein FOL1 [Includes: Dihydroneopterin aldolase

1

0

High-throughput

0.460

High

626474

RHO5
GTP-binding protein RHO5

1

0

Small-scale

0.460

High

626478

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.460

High

626485

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.460

High

626491

YP097
PX domain-containing protein YPR097W

1

0

Small-scale

0.460

High

626492

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.460

High

626497

DAP1
Damage response protein 1

1

0

High-throughput

0.460

High

626456

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

626480

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

626493

LAM6
Membrane-anchored lipid-binding protein LAM6

1

0

Small-scale

0.458

High

626427

PEX5
Peroxisomal targeting signal receptor

1

1

High-throughput

0.439

High

626428

TOR1
Serine/threonine-protein kinase TOR1

1

3

High-throughput

0.439

High

626463

JSN1
Protein JSN1

1

3

High-throughput

0.439

High

365841

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.437

High

605299

HSP74
Heat shock protein SSA4

1

5

High-throughput

0.437

High

626411

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

626414

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

626424

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.437

High

626443

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

626481

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

554564

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

626420

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.407

High

626450

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.407

High

626429

DYHC
Dynein heavy chain, cytoplasmic

2

0

Small-scale

0.326

High

626496

NUR1
Nuclear rim protein 1

1

0

High-throughput

0.282

High

626498

YOR97
Uncharacterized protein YOR097C

1

0

High-throughput

0.282

High

626422

PEX2
Peroxisomal biogenesis factor 2

1

0

High-throughput

0.251

Low

626435

PEX32
Peroxisomal membrane protein PEX32

1

0

High-throughput

0.251

Low

626453

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.251

Low

626471

YTP1
Protein YTP1

1

0

High-throughput

0.251

Low

626476

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.251

Low

626477

PEX25
Peroxisomal membrane protein PEX25

1

0

High-throughput

0.251

Low

626479

INP1
Inheritance of peroxisomes protein 1

1

0

High-throughput

0.251

Low

626482

PEX12
Peroxisome assembly protein 12

1

0

High-throughput

0.251

Low

626487

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.251

Low

606549

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

626433

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.249

Low

626434

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

626445

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

626464

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

626494

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

626495

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

626459

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024