Protein: ASF1
Histone chaperone ASF1 (Anti-silencing function protein 1) (yASF1)

Gene: ASF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 206
UniProt ID: P32447

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006282 - regulation of DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

736700

H3
Histone H3

31

19

Small-scale

0.992

High

381947

H4
Histone H4

21

5

Small-scale

0.988

High

736614

HIR1
Protein HIR1

9

18

Small-scale

0.971

High

736740

RT109
Histone acetyltransferase RTT109

5

0

Small-scale

0.882

High

736632

BDF1
Bromodomain-containing factor 1

2

5

Small-scale

0.768

High

736615

HIR2
Protein HIR2

8

16

Small-scale

0.747

High

736676

HIR3
Histone transcription regulator 3

8

1

Small-scale

0.744

High

381449

H2B2
Histone H2B.2

2

1

Small-scale

0.737

High

736763

H2AZ
Histone H2A.Z

2

1

Small-scale

0.737

High

646339

RAD53
Serine/threonine-protein kinase RAD53

23

0

Small-scale

0.734

High

736703

HPC2
Histone promoter control protein 2

6

4

Small-scale

0.722

High

419651

H2A2
Histone H2A.2

2

0

Small-scale

0.699

High

736663

SAS2
Histone acetyltransferase SAS2

3

2

Small-scale

0.674

High

736722

SAS4
Something about silencing protein 4

4

0

Small-scale

0.668

High

736766

SAS5
Something about silencing protein 5

3

2

Small-scale

0.658

High

381014

H2B1
Histone H2B.1

1

1

Small-scale

0.618

High

643612

SNF2
Transcription regulatory protein SNF2

1

11

Small-scale

0.618

High

736629

SPT7
SAGA complex subunit SPT7

1

8

Small-scale

0.618

High

736716

GCN5
Histone acetyltransferase GCN5

1

4

Small-scale

0.618

High

736739

BDF2
Bromodomain-containing factor 2

1

5

Small-scale

0.618

High

736757

HIF1
HAT1-interacting factor 1

3

0

Small-scale

0.613

High

488596

RIR2
Ribonucleoside-diphosphate reductase small chain 1

2

1

High-throughput

0.601

High

736678

RIR4
Ribonucleoside-diphosphate reductase small chain 2

2

1

High-throughput

0.601

High

585880

CSK21
Casein kinase II subunit alpha

2

1

High-throughput

0.588

High

622897

CSK22
Casein kinase II subunit alpha'

2

1

High-throughput

0.588

High

736762

CAF1A
Chromatin assembly factor 1 subunit A

2

5

Small-scale

0.585

High

736651

HAT2
Histone acetyltransferase type B subunit 2

2

6

Small-scale

0.584

High

736755

HAT1
Histone acetyltransferase type B catalytic subunit

2

2

Small-scale

0.584

High

736654

RT106
Histone chaperone RTT106

2

0

Small-scale

0.577

High

544152

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.576

High

712954

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.575

High

736613

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.575

High

736619

STH1
Nuclear protein STH1/NPS1

1

11

High-throughput

0.575

High

736705

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

10

High-throughput

0.575

High

736735

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

10

High-throughput

0.575

High

736636

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

2

3

Small-scale

0.571

High

736644

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

2

1

Small-scale

0.571

High

364408

CDK1
Cyclin-dependent kinase 1

2

0

Small-scale

0.569

High

526165

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

561436

TBP
TATA-box-binding protein

2

0

Small-scale

0.547

High

694501

SPT5
Transcription elongation factor SPT5

2

0

Small-scale

0.547

High

736681

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

0

Small-scale

0.547

High

736719

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

2

0

Small-scale

0.547

High

736748

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

2

0

Small-scale

0.547

High

736741

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.546

High

736738

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

Small-scale

0.537

High

445324

CDC31
Cell division control protein 31

2

1

Small-scale

0.521

High

647724

RFA1
Replication factor A protein 1

1

1

High-throughput

0.515

High

736653

IMB4
Importin subunit beta-4

1

3

Small-scale

0.501

High

736723

CAF1B
Chromatin assembly factor 1 subunit B

1

16

Small-scale

0.501

High

736744

ESA1
Histone acetyltransferase ESA1

1

3

Small-scale

0.501

High

699986

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.493

High

736505

SFP1
Transcription factor SFP1

1

0

High-throughput

0.493

High

736650

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.480

High

706486

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

736639

RFC5
Replication factor C subunit 5

1

3

Small-scale

0.479

High

736641

RFC3
Replication factor C subunit 3

1

3

Small-scale

0.479

High

736642

RFC1
Replication factor C subunit 1

1

4

Small-scale

0.479

High

736655

RFC4
Replication factor C subunit 4

1

4

Small-scale

0.479

High

736656

RFC2
Replication factor C subunit 2

1

3

Small-scale

0.479

High

736664

T2FB
Transcription initiation factor IIF subunit beta

1

1

Small-scale

0.479

High

736669

SAC3
Nuclear mRNA export protein SAC3

1

1

Small-scale

0.479

High

736671

TAF1
Transcription initiation factor TFIID subunit 1

1

1

Small-scale

0.479

High

736673

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

2

Small-scale

0.479

High

736692

BRE5
UBP3-associated protein BRE5

1

1

Small-scale

0.479

High

736704

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

Small-scale

0.479

High

736707

ADA2
SAGA complex subunit ADA2

1

3

Small-scale

0.479

High

736751

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

736752

YRA1
RNA annealing protein YRA1

1

2

Small-scale

0.479

High

449403

SPT2
Protein SPT2

1

0

Small-scale

0.458

High

449444

SPT3
SAGA complex subunit SPT3

1

0

Small-scale

0.458

High

534233

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

Small-scale

0.458

High

550632

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.458

High

605879

HPR1
THO complex subunit HPR1

1

0

Small-scale

0.458

High

676614

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.458

High

734884

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

736616

NGG1
SAGA complex subunit NGG1

1

0

Small-scale

0.458

High

736617

NUP2
Nucleoporin NUP2

1

0

Small-scale

0.458

High

736648

NUP60
Nucleoporin NUP60

1

0

Small-scale

0.458

High

736675

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

736679

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.458

High

736680

SPT20
SAGA complex subunit SPT20

1

0

Small-scale

0.458

High

736686

SGF73
SAGA complex subunit SGF73

1

0

Small-scale

0.458

High

736694

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

736714

SGF11
SAGA complex subunit SGF11

1

0

Small-scale

0.458

High

736727

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.458

High

736729

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

Small-scale

0.458

High

736731

RT103
Regulator of Ty1 transposition protein 103

1

0

Small-scale

0.458

High

736736

IWS1
Transcription factor SPN1

1

0

Small-scale

0.458

High

736742

THP1
Nuclear mRNA export protein THP1

1

0

Small-scale

0.458

High

736749

HFI1
SAGA complex subunit HFI1

1

0

Small-scale

0.458

High

736754

SMT3
Ubiquitin-like protein SMT3

1

0

Small-scale

0.458

High

736765

SUS1
SAGA complex subunit SUS1

1

0

Small-scale

0.458

High

504627

YP12B
Transposon Ty1-PR1 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

523348

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

547772

NHP6A
Non-histone chromosomal protein 6A

1

2

High-throughput

0.445

High

614805

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

1

High-throughput

0.445

High

678301

RSC6
Chromatin structure-remodeling complex protein RSC6

1

1

High-throughput

0.445

High

682904

MSH2
DNA mismatch repair protein MSH2

1

1

High-throughput

0.445

High

708696

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.445

High

734391

BTAF1
TATA-binding protein-associated factor MOT1

1

12

High-throughput

0.445

High

736618

SWI3
SWI/SNF complex subunit SWI3

1

3

High-throughput

0.445

High

736621

CHD1
Chromo domain-containing protein 1

1

7

High-throughput

0.445

High

736624

PDC2
Protein PDC2

1

2

High-throughput

0.445

High

736625

TFC4
Transcription factor tau 131 kDa subunit

1

1

High-throughput

0.445

High

736628

TOR1
Serine/threonine-protein kinase TOR1

1

1

High-throughput

0.445

High

736630

TAF14
Transcription initiation factor TFIID subunit 14

1

2

High-throughput

0.445

High

736637

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

10

High-throughput

0.445

High

736643

RSC30
Chromatin structure-remodeling complex protein RSC30

1

1

High-throughput

0.445

High

736659

ASG1
Activator of stress genes 1

1

1

High-throughput

0.445

High

736667

RSC8
Chromatin structure-remodeling complex protein RSC8

1

3

High-throughput

0.445

High

736682

MCM6
DNA replication licensing factor MCM6

1

12

High-throughput

0.445

High

736683

INO80
Chromatin-remodeling ATPase INO80

1

10

High-throughput

0.445

High

736684

ITC1
Imitation switch two complex protein 1

1

1

High-throughput

0.445

High

736691

SNF12
Transcription regulatory protein SNF12

1

1

High-throughput

0.445

High

736695

ARP5
Actin-related protein 5

1

1

High-throughput

0.445

High

736696

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.445

High

736698

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.445

High

736701

ARP4
Actin-related protein 4

1

2

High-throughput

0.445

High

736711

HOS3
Histone deacetylase HOS3

1

1

High-throughput

0.445

High

736717

NHP10
Non-histone protein 10

1

1

High-throughput

0.445

High

736720

MSH6
DNA mismatch repair protein MSH6

1

1

High-throughput

0.445

High

736721

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

736728

TRI1
Protein TRI1

1

1

High-throughput

0.445

High

736730

ARP9
Actin-like protein ARP9

1

1

High-throughput

0.445

High

736733

IMB1
Importin subunit beta-1

1

3

High-throughput

0.445

High

736737

RSC3
Chromatin structure-remodeling complex protein RSC3

1

1

High-throughput

0.445

High

736745

UAF30
Upstream activation factor subunit UAF30

1

1

High-throughput

0.445

High

736746

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

11

High-throughput

0.445

High

736758

ARP8
Actin-like protein ARP8

1

1

High-throughput

0.445

High

736759

ARP7
Actin-related protein 7

1

2

High-throughput

0.445

High

736761

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.445

High

149200

FOB1
DNA replication fork-blocking protein FOB1

1

0

High-throughput

0.426

High

392407

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

444751

SIR2
NAD-dependent histone deacetylase SIR2

1

0

High-throughput

0.426

High

448150

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

448439

RAD52
DNA repair and recombination protein RAD52

1

0

High-throughput

0.426

High

453477

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

454336

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.426

High

553518

PDR1
Transcription factor PDR1

1

0

High-throughput

0.426

High

670460

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

735974

SP110
Spindle pole body component 110

1

0

High-throughput

0.426

High

736622

T2AG
Transcription initiation factor IIA subunit 2

1

0

High-throughput

0.426

High

736623

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.426

High

736627

SPC29
Spindle pole component 29

1

0

High-throughput

0.426

High

736634

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

High-throughput

0.426

High

736638

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.426

High

736647

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

736649

SNF7
Vacuolar-sorting protein SNF7

1

0

High-throughput

0.426

High

736652

MIT1
Transcriptional regulator MIT1

1

0

High-throughput

0.426

High

736658

DLS1
Protein DLS1

1

0

High-throughput

0.426

High

736662

MPH1
ATP-dependent DNA helicase MPH1

1

0

High-throughput

0.426

High

736666

IES1
Ino eighty subunit 1

1

0

High-throughput

0.426

High

736670

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.426

High

736685

SLD3
DNA replication regulator SLD3

1

0

High-throughput

0.426

High

736687

ENV11
Late endosome and vacuole interface protein 11

1

0

High-throughput

0.426

High

736688

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.426

High

736689

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.426

High

736690

H1
Histone H1

1

0

High-throughput

0.426

High

736693

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

736697

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.426

High

736699

ACT
Actin

1

0

High-throughput

0.426

High

736702

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.426

High

736708

TBF1
Protein TBF1

1

0

High-throughput

0.426

High

736709

IMA1
Importin subunit alpha

1

0

High-throughput

0.426

High

736712

RRN5
RNA polymerase I-specific transcription initiation factor RRN5

1

0

High-throughput

0.426

High

736715

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.426

High

736725

DPB4
DNA polymerase epsilon subunit D

1

0

High-throughput

0.426

High

736726

RRN11
RNA polymerase I-specific transcription initiation factor RRN11

1

0

High-throughput

0.426

High

736734

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.426

High

736743

IES4
Ino eighty subunit 4

1

0

High-throughput

0.426

High

736753

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.426

High

736756

IES3
Ino eighty subunit 3

1

0

High-throughput

0.426

High

736760

TFC7
Transcription factor tau 55 kDa subunit

1

0

High-throughput

0.426

High

510298

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

577068

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.407

High

736633

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.407

High

736646

CSK2C
Casein kinase II subunit beta'

1

1

High-throughput

0.407

High

736668

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.407

High

736674

NET1
Nucleolar protein NET1

1

1

High-throughput

0.407

High

736706

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.407

High

736732

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

3

High-throughput

0.407

High

736747

YP204
Y' element ATP-dependent helicase YPR204W

1

1

High-throughput

0.407

High

736661

MAM33
Mitochondrial acidic protein MAM33

2

0

High-throughput

0.313

High

449090

CALM
Calmodulin

1

0

High-throughput

0.269

Low

736660

QDR2
Quinidine resistance protein 2

1

0

High-throughput

0.269

Low

736713

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

0

High-throughput

0.261

Low

736635

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

Small-scale

0.249

Low

736677

NUP57
Nucleoporin NUP57

1

0

Small-scale

0.249

Low

736718

ROT1
Protein ROT1

1

0

High-throughput

0.238

Low

561669

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.232

Low

586067

DPOG
DNA polymerase gamma

1

0

High-throughput

0.232

Low

678856

CSM1
Monopolin complex subunit CSM1

1

0

High-throughput

0.232

Low

736620

ANP1
Mannan polymerase II complex ANP1 subunit

1

0

High-throughput

0.232

Low

736626

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

736631

MNR2
Manganese resistance protein MNR2

1

0

High-throughput

0.232

Low

736640

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.232

Low

736645

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.232

Low

736657

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

736665

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.232

Low

736672

TFC5
Transcription factor TFIIIB component B''

1

0

High-throughput

0.232

Low

736710

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

High-throughput

0.232

Low

736724

HFD1
Fatty aldehyde dehydrogenase HFD1

1

0

High-throughput

0.232

Low

736750

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.232

Low

736764

CENPS
Inner kinetochore subunit MHF1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025