Protein: HOSM
Homocitrate synthase, mitochondrial (HCS) (EC 2.3.3.14)

Gene: HOSM, LYS21
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: Q12122

Gene Ontology (top 5):
GO:0004410 - homocitrate synthase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0019878 - lysine biosynthetic process via aminoadipic acid
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

819996

HOSC
Homocitrate synthase, cytosolic isozyme

4

13

High-throughput

0.896

High

1015062

HOSM
Homocitrate synthase, mitochondrial

1

13

High-throughput

0.698

High

492774

HSP71
Heat shock protein SSA1

4

9

High-throughput

0.666

High

797630

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

5

High-throughput

0.640

High

367062

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.614

High

495254

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

769755

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

425394

PHO4
Phosphate system positive regulatory protein PHO4

1

1

High-throughput

0.536

High

865354

SYC
Cysteine--tRNA ligase

1

1

High-throughput

0.515

High

565822

PHO85
Cyclin-dependent protein kinase PHO85

1

4

High-throughput

0.501

High

611041

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.501

High

703287

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.501

High

752240

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

797315

WWM1
WW domain-containing protein WWM1

1

1

High-throughput

0.501

High

810379

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

1

High-throughput

0.501

High

1015065

PRR2
Serine/threonine-protein kinase PRR2

1

5

High-throughput

0.501

High

1015066

SKM1
Serine/threonine-protein kinase SKM1

1

1

High-throughput

0.501

High

688841

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.493

High

419983

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.479

High

544578

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

558317

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

625872

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

628576

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

663626

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

681072

HS104
Heat shock protein 104

1

6

High-throughput

0.479

High

688483

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

689647

MET4
Transcriptional activator of sulfur metabolism MET4

1

1

High-throughput

0.479

High

692640

ZUO1
Zuotin

1

5

Small-scale

0.479

High

703757

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

743053

GBLP
Small ribosomal subunit protein RACK1

1

3

Small-scale

0.479

High

860635

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

977715

GIS1
Transcriptional activator/repressor GIS1

1

1

High-throughput

0.479

High

978040

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

1015011

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1015063

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1015064

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

608493

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

753980

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

757044

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

765098

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

775001

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

797107

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

959896

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

513130

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

560823

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

695763

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

766274

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

774680

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

539611

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.438

High

524481

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

701133

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

713274

TSA1
Peroxiredoxin TSA1

1

1

Small-scale

0.437

High

864186

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.437

High

761105

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.407

High

988610

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

767928

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.296

High

482955

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

749084

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

762039

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

822953

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

785270

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

804868

RSSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024