Protein: CLPP
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Caseinolytic protease) (Endopeptidase Clp) (Heat shock protein F21.5) (Protease Ti)

Gene: CLPP
Organism: Escherichia coli K-12
Interactions: 68
UniProt ID: P0A6G7

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006515 - protein quality control for misfolded or incompletely synthesized proteins

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

490227

CLPP
ATP-dependent Clp protease proteolytic subunit

5

11

Small-scale

0.935

High

490253

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

4

4

Small-scale

0.902

High

490228

CLPX
ATP-dependent Clp protease ATP-binding subunit ClpX

3

6

Small-scale

0.857

High

490113

CH10
Co-chaperonin GroES

1

1

High-throughput

0.618

High

489471

CH60
Chaperonin GroEL

2

2

High-throughput

0.612

High

490257

RHO
Transcription termination factor Rho

2

2

High-throughput

0.612

High

397486

KEFC
Glutathione-regulated potassium-efflux system protein KefC

2

0

High-throughput

0.563

High

490255

RRAB
Regulator of ribonuclease activity B

2

0

High-throughput

0.563

High

490231

KPRS
Ribose-phosphate pyrophosphokinase

1

2

High-throughput

0.536

High

490278

KAD
Adenylate kinase

1

2

High-throughput

0.536

High

456981

CHEA
Chemotaxis protein CheA

1

0

High-throughput

0.513

High

490247

TIG
Trigger factor

1

0

High-throughput

0.513

High

490249

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

0

High-throughput

0.513

High

490269

RHLE
ATP-dependent RNA helicase RhlE

1

0

High-throughput

0.513

High

490270

BASR
Transcriptional regulatory protein BasR

1

0

High-throughput

0.513

High

382621

RS7
Small ribosomal subunit protein uS7

1

1

High-throughput

0.484

High

479532

NARG
Respiratory nitrate reductase 1 alpha chain

1

1

High-throughput

0.484

High

490230

DNAK
Chaperone protein DnaK

1

2

High-throughput

0.484

High

490234

RL11
Large ribosomal subunit protein uL11

1

1

High-throughput

0.484

High

490235

RL7
Large ribosomal subunit protein bL12

1

1

High-throughput

0.484

High

490236

RL19
Large ribosomal subunit protein bL19

1

1

High-throughput

0.484

High

490241

RS10
Small ribosomal subunit protein uS10

1

1

High-throughput

0.484

High

490250

LON
Lon protease

1

3

High-throughput

0.484

High

490260

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

2

High-throughput

0.484

High

490265

NARZ
Respiratory nitrate reductase 2 alpha chain

1

1

High-throughput

0.484

High

490274

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.484

High

490277

HLDD
ADP-L-glycero-D-manno-heptose-6-epimerase

1

3

High-throughput

0.484

High

382537

RS6
Small ribosomal subunit protein bS6

1

0

High-throughput

0.464

High

477366

T1RK
Type I restriction enzyme EcoKI endonuclease subunit

1

0

High-throughput

0.464

High

490229

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.464

High

490233

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.464

High

490237

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.464

High

490238

RL28
Large ribosomal subunit protein bL28

1

0

High-throughput

0.464

High

490240

RL33
Large ribosomal subunit protein bL33

1

0

High-throughput

0.464

High

490245

METK
S-adenosylmethionine synthase

1

0

High-throughput

0.464

High

490248

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.464

High

490251

RL13
Large ribosomal subunit protein uL13

1

0

High-throughput

0.464

High

490254

GYRA
DNA gyrase subunit A

1

0

High-throughput

0.464

High

490256

ODP1
Pyruvate dehydrogenase E1 component

1

0

High-throughput

0.464

High

490258

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.464

High

490259

UGPB
sn-glycerol-3-phosphate-binding periplasmic protein UgpB

1

0

High-throughput

0.464

High

490261

DEGP
Periplasmic serine endoprotease DegP

1

0

High-throughput

0.464

High

490266

PARE
DNA topoisomerase 4 subunit B

1

0

High-throughput

0.464

High

490272

AGAI
Putative deaminase AgaI

1

0

High-throughput

0.464

High

490273

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.464

High

490275

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.464

High

490252

THIO
Thioredoxin 1

1

1

Small-scale

0.445

High

490242

RS16
Small ribosomal subunit protein bS16

1

1

High-throughput

0.442

High

490243

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.442

High

490262

EFTU1
Elongation factor Tu 1

1

2

High-throughput

0.442

High

490263

EFTU2
Elongation factor Tu 2

1

2

High-throughput

0.407

High

365250

PTM3C
PTS system mannitol-specific EIICBA component

2

0

High-throughput

0.307

High

490276

YDIH
Uncharacterized protein YdiH

2

0

High-throughput

0.307

High

490244

RNH
Ribonuclease HI

1

0

High-throughput

0.279

Low

490246

TATE
Sec-independent protein translocase protein TatE

1

0

High-throughput

0.279

Low

490267

MUTL
DNA mismatch repair protein MutL

1

0

High-throughput

0.279

Low

490268

RHSE
Putative protein RhsE

1

0

High-throughput

0.279

Low

490271

YEHC
Probable fimbrial chaperone YehC

1

0

High-throughput

0.279

Low

490279

YAHN
Uncharacterized membrane protein YahN

1

0

High-throughput

0.279

Low

490280

GFCD
Uncharacterized lipoprotein GfcD

1

0

High-throughput

0.279

Low

490281

FLGA
Flagella basal body P-ring formation protein FlgA

1

0

High-throughput

0.279

Low

490282

RLUE
Ribosomal large subunit pseudouridine synthase E

1

0

High-throughput

0.279

Low

490232

RECA
Protein RecA

1

0

High-throughput

0.253

Low

490239

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.253

Low

490264

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.253

Low

490283

YEGL
Uncharacterized protein YegL

1

0

High-throughput

0.253

Low

490284

DSBG
Thiol:disulfide interchange protein DsbG

1

0

High-throughput

0.253

Low


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Last updated: 11Aug2025