Protein: SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SLX8) (Synthetic lethal of unknown function protein 8)

Gene: SLX8
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: P40072

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000776 - kinetochore
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549817

UBC4
Ubiquitin-conjugating enzyme E2 4

3

1

Small-scale

0.845

High

698549

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

13

0

Small-scale

0.726

High

549858

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

1

Small-scale

0.647

High

767865

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.621

High

477303

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.614

High

767876

SMT3
Ubiquitin-like protein SMT3

3

0

Small-scale

0.605

High

767875

SIZ2
E3 SUMO-protein ligase SIZ2

2

1

Small-scale

0.594

High

767868

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.590

High

483020

HMAL2
Silenced mating-type protein ALPHA2

2

0

Small-scale

0.577

High

767871

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

Small-scale

0.536

High

764061

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.515

High

692458

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.504

High

767874

ELG1
Telomere length regulation protein ELG1

1

0

Small-scale

0.504

High

356502

H4
Histone H4

1

0

High-throughput

0.493

High

392447

H2A2
Histone H2A.2

1

0

High-throughput

0.493

High

420129

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.493

High

759356

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

767864

ASE1
Anaphase spindle elongation protein

1

0

High-throughput

0.493

High

767869

ABF2
ARS-binding factor 2, mitochondrial

1

0

High-throughput

0.493

High

767870

HMO1
High mobility group protein 1

1

0

High-throughput

0.493

High

419618

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.480

High

565617

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

701880

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.480

High

767861

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

Small-scale

0.480

High

629634

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.470

High

756045

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.460

High

767873

ULS1
ATP-dependent helicase ULS1

1

0

Small-scale

0.460

High

767872

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

366365

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

491368

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

494085

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

511488

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

543824

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.445

High

694790

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

767862

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

767867

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

705231

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

754446

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

520989

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

767866

NUP84
Nucleoporin NUP84

1

0

Small-scale

0.249

Low

715520

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.238

Low

767863

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024