Protein: RRP46
Exosome complex component RRP46 (Ribosomal RNA-processing protein 46)

Gene: RRP46
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P53256

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

860819

RRP44
Exosome complex exonuclease DIS3

15

16

Small-scale

0.983

High

860795

CSL4
Exosome complex component CSL4

15

10

Small-scale

0.983

High

809565

RRP41
Exosome complex component SKI6

13

18

Small-scale

0.980

High

630229

RRP43
Exosome complex component RRP43

12

2

Small-scale

0.980

High

754976

RRP4
Exosome complex component RRP4

9

20

Small-scale

0.970

High

860807

RRP45
Exosome complex component RRP45

9

20

Small-scale

0.970

High

860820

RRP40
Exosome complex component RRP40

9

11

Small-scale

0.970

High

816957

MTR3
Exosome complex component MTR3

7

1

Small-scale

0.960

High

860790

RRP46
Exosome complex component RRP46

3

17

Small-scale

0.830

High

860826

RRP6
Exosome complex exonuclease RRP6

12

9

Small-scale

0.757

High

860829

RRP42
Exosome complex component RRP42

10

20

Small-scale

0.754

High

860821

SKI7
Superkiller protein 7

10

7

Small-scale

0.752

High

755184

LRP1
Exosome complex protein LRP1

6

2

Small-scale

0.729

High

860793

MPP6
M-phase phosphoprotein 6 homolog

4

2

Small-scale

0.696

High

860704

UTP22
U3 small nucleolar RNA-associated protein 22

3

3

High-throughput

0.643

High

748664

ENP1
Essential nuclear protein 1

3

2

High-throughput

0.640

High

860802

DHR1
Probable ATP-dependent RNA helicase DHR1

3

2

High-throughput

0.640

High

860805

RRP5
rRNA biogenesis protein RRP5

1

6

High-throughput

0.618

High

769023

SSB2
Ribosome-associated molecular chaperone SSB2

3

5

High-throughput

0.611

High

860799

IMA1
Importin subunit alpha

2

1

High-throughput

0.588

High

634704

KRR1
KRR1 small subunit processome component

2

2

High-throughput

0.584

High

792516

UTP10
U3 small nucleolar RNA-associated protein 10

2

2

High-throughput

0.584

High

810881

MTR4
ATP-dependent RNA helicase DOB1

2

14

Small-scale

0.584

High

860804

UTP14
U3 small nucleolar RNA-associated protein 14

2

3

High-throughput

0.584

High

860814

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

494538

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

585351

MYO2
Myosin-2

2

1

High-throughput

0.537

High

491934

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.536

High

860792

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.513

High

566208

EST1
Telomere elongation protein EST1

1

2

High-throughput

0.479

High

571912

SKI3
Superkiller protein 3

1

3

High-throughput

0.479

High

630517

RRP7
Ribosomal RNA-processing protein 7

1

2

High-throughput

0.479

High

635615

PWP2
Periodic tryptophan protein 2

1

11

High-throughput

0.479

High

662864

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

707116

DCA13
Protein SOF1

1

6

High-throughput

0.479

High

711055

UTP11
U3 small nucleolar RNA-associated protein 11

1

2

High-throughput

0.479

High

715956

UTP20
U3 small nucleolar RNA-associated protein 20

1

2

High-throughput

0.479

High

716197

SKI2
Antiviral helicase SKI2

1

14

High-throughput

0.479

High

728286

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.479

High

756761

UTP9
U3 small nucleolar RNA-associated protein 9

1

2

High-throughput

0.479

High

767389

UTP7
U3 small nucleolar RNA-associated protein 7

1

2

High-throughput

0.479

High

772653

UTP18
U3 small nucleolar RNA-associated protein 18

1

3

High-throughput

0.479

High

775373

FAF1
Protein FAF1

1

1

High-throughput

0.479

High

784514

DIM1
Dimethyladenosine transferase

1

2

High-throughput

0.479

High

799835

ROK1
ATP-dependent RNA helicase ROK1

1

1

High-throughput

0.479

High

811533

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

860791

UTP8
U3 small nucleolar RNA-associated protein 8

1

2

High-throughput

0.479

High

860796

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

860797

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

860798

UTP6
U3 small nucleolar RNA-associated protein 6

1

2

High-throughput

0.479

High

860800

UTP17
NET1-associated nuclear protein 1

1

18

High-throughput

0.479

High

860801

UTP5
U3 small nucleolar RNA-associated protein 5

1

11

High-throughput

0.479

High

860803

UTP15
U3 small nucleolar RNA-associated protein 15

1

7

High-throughput

0.479

High

860806

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

860809

UTP13
U3 small nucleolar RNA-associated protein 13

1

11

High-throughput

0.479

High

860810

UTP21
U3 small nucleolar RNA-associated protein 21

1

15

High-throughput

0.479

High

860811

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

2

High-throughput

0.479

High

860813

RRP9
Ribosomal RNA-processing protein 9

1

8

High-throughput

0.479

High

860815

BFR2
Protein BFR2

1

2

High-throughput

0.479

High

860817

UTP4
U3 small nucleolar RNA-associated protein 4

1

12

High-throughput

0.479

High

860818

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

2

High-throughput

0.479

High

860822

UTP16
U3 small nucleolar RNA-associated protein 16

1

2

High-throughput

0.479

High

860823

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

860824

FCF2
rRNA-processing protein FCF2

1

2

High-throughput

0.479

High

860825

SAS10
Something about silencing protein 10

1

3

High-throughput

0.479

High

860828

UTP12
U3 small nucleolar RNA-associated protein 12

1

14

High-throughput

0.479

High

860830

NOP56
Nucleolar protein 56

1

5

High-throughput

0.479

High

860831

NOP58
Nucleolar protein 58

1

5

High-throughput

0.479

High

860832

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

593077

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

774262

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

860812

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

860827

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

860833

PNO1
Pre-rRNA-processing protein PNO1

1

0

Small-scale

0.458

High

376869

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.445

High

512133

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

695172

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

399568

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

837320

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.407

High

860808

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

9

High-throughput

0.407

High

860794

IST1
Vacuolar protein sorting-associated protein IST1

2

0

High-throughput

0.307

High

860816

CENPO
Inner kinetochore subunit MCM21

1

0

High-throughput

0.249

Low

544141

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

810082

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024