Protein: HIS2
Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase (PRA-CH) (EC 3.5.4.19); Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31)]

Gene: HIS2, hisI
Organism: Escherichia coli K-12
Interactions: 15
UniProt ID: P06989

Gene Ontology (top 5):
GO:0000105 - L-histidine biosynthetic process
GO:0004635 - phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 - phosphoribosyl-ATP diphosphatase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449982

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

449984

RS5
Small ribosomal subunit protein uS5

1

0

High-throughput

0.513

High

449985

CSPI
Cold shock-like protein CspI

1

0

High-throughput

0.513

High

449988

FENR
Flavodoxin/ferredoxin--NADP reductase

1

0

High-throughput

0.513

High

449990

YJHG
D-xylonate dehydratase YjhG

1

0

High-throughput

0.513

High

449994

PRPE
Propionate--CoA ligase

1

0

High-throughput

0.513

High

449983

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.426

High

407944

FRSA
Esterase FrsA

1

0

High-throughput

0.279

Low

439004

DLD
Quinone-dependent D-lactate dehydrogenase

1

0

High-throughput

0.279

Low

449986

RS17
Small ribosomal subunit protein uS17

1

0

High-throughput

0.279

Low

449987

MANC
Mannose-1-phosphate guanylyltransferase

1

0

High-throughput

0.279

Low

449989

OPGG
Glucans biosynthesis protein G

1

0

High-throughput

0.279

Low

449991

YGHW
Uncharacterized protein YghW

1

0

High-throughput

0.279

Low

449992

VXIS
Prophage excisionase-like protein

1

0

High-throughput

0.279

Low

449993

PAOC
Aldehyde oxidoreductase molybdenum-binding subunit PaoC

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025