Protein: RS4
Small ribosomal subunit protein uS4 (30S ribosomal protein S4)

Gene: RS4, rpsD
Organism: Escherichia coli K-12
Interactions: 236
UniProt ID: P0A7V8

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

494025

RS5
Small ribosomal subunit protein uS5

2

1

High-throughput

0.789

High

494058

RSUA
Ribosomal small subunit pseudouridine synthase A

2

3

High-throughput

0.759

High

494026

RS8
Small ribosomal subunit protein uS8

1

2

High-throughput

0.698

High

494045

CSPE
Cold shock-like protein CspE

3

5

High-throughput

0.657

High

494122

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

3

3

High-throughput

0.657

High

494070

HSLR
Heat shock protein 15

1

0

High-throughput

0.656

High

491923

RPPH
RNA pyrophosphohydrolase

3

0

High-throughput

0.629

High

494090

NUSA
Transcription termination/antitermination protein NusA

3

0

High-throughput

0.629

High

494157

RLMN
Dual-specificity RNA methyltransferase RlmN

3

0

High-throughput

0.629

High

494057

RLUC
Ribosomal large subunit pseudouridine synthase C

1

3

High-throughput

0.625

High

494165

RLUB
Ribosomal large subunit pseudouridine synthase B

1

3

High-throughput

0.625

High

494148

RLUF
Dual-specificity RNA pseudouridine synthase RluF

1

2

High-throughput

0.618

High

494055

CSPA
Cold shock protein CspA

2

5

High-throughput

0.612

High

494056

CSPC
Cold shock-like protein CspC

2

5

High-throughput

0.612

High

494125

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

3

0

High-throughput

0.607

High

494034

UVRC
UvrABC system protein C

2

1

High-throughput

0.601

High

494040

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.593

High

421100

PNP
Polyribonucleotide nucleotidyltransferase

2

1

High-throughput

0.588

High

494037

RHLB
ATP-dependent RNA helicase RhlB

2

2

High-throughput

0.588

High

494114

SELB
Selenocysteine-specific elongation factor

2

1

High-throughput

0.588

High

490860

HFQ
RNA-binding protein Hfq

2

0

High-throughput

0.585

High

494029

RPOA
DNA-directed RNA polymerase subunit alpha

2

0

High-throughput

0.585

High

494208

DCYD
D-cysteine desulfhydrase

2

0

High-throughput

0.576

High

493839

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.575

High

494024

RS4
Small ribosomal subunit protein uS4

1

1

High-throughput

0.575

High

490920

IHFA
Integration host factor subunit alpha

2

3

High-throughput

0.570

High

491480

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

2

0

High-throughput

0.563

High

494095

SPOT
Bifunctional

2

0

High-throughput

0.563

High

494101

SRP54
Signal recognition particle protein

2

0

High-throughput

0.563

High

494120

RNR
Ribonuclease R

2

0

High-throughput

0.563

High

494150

AIDB
Putative acyl-CoA dehydrogenase AidB

2

0

High-throughput

0.563

High

494154

CBPA
Curved DNA-binding protein

2

0

High-throughput

0.563

High

494182

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.563

High

491585

KPRS
Ribose-phosphate pyrophosphokinase

2

0

High-throughput

0.547

High

494102

SSB
Single-stranded DNA-binding protein

2

0

High-throughput

0.547

High

494105

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

2

0

High-throughput

0.545

High

494197

NPD
NAD-dependent protein deacylase

2

0

High-throughput

0.545

High

494184

FLAV
Flavodoxin 1

1

1

High-throughput

0.541

High

382643

RS7
Small ribosomal subunit protein uS7

1

2

High-throughput

0.536

High

491734

LPXA
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

1

3

High-throughput

0.536

High

493318

RS12
Small ribosomal subunit protein uS12

1

1

High-throughput

0.536

High

493349

RS13
Small ribosomal subunit protein uS13

1

2

High-throughput

0.536

High

493457

RS16
Small ribosomal subunit protein bS16

1

1

High-throughput

0.536

High

493556

RS19
Small ribosomal subunit protein uS19

1

2

High-throughput

0.536

High

494027

RS9
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

494046

CSPG
Cold shock-like protein CspG

1

5

High-throughput

0.536

High

494047

CSPI
Cold shock-like protein CspI

1

5

High-throughput

0.536

High

494050

RNG
Ribonuclease G

1

1

High-throughput

0.536

High

494066

GLMU
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase

1

1

High-throughput

0.536

High

494067

DBHA
DNA-binding protein HU-alpha

1

3

High-throughput

0.536

High

494068

DBHB
DNA-binding protein HU-beta

1

3

High-throughput

0.536

High

494081

RS15
Small ribosomal subunit protein uS15

1

1

High-throughput

0.536

High

494097

RS14
Small ribosomal subunit protein uS14

1

1

High-throughput

0.536

High

494098

RS1
Small ribosomal subunit protein bS1

1

1

High-throughput

0.536

High

494103

THIO2
Thioredoxin 2

1

1

High-throughput

0.536

High

494134

RHLE
ATP-dependent RNA helicase RhlE

1

2

High-throughput

0.536

High

368787

SYW
Tryptophan--tRNA ligase

1

0

High-throughput

0.513

High

408521

3MG2
DNA-3-methyladenine glycosylase 2

1

0

High-throughput

0.513

High

420210

EX7L
Exodeoxyribonuclease 7 large subunit

1

0

High-throughput

0.513

High

490699

FIS
DNA-binding protein Fis

1

0

High-throughput

0.513

High

492679

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

494036

RLMH
Ribosomal RNA large subunit methyltransferase H

1

0

High-throughput

0.513

High

494061

KBAY
D-tagatose-1,6-bisphosphate aldolase subunit KbaY

1

0

High-throughput

0.513

High

494065

GLRX4
Glutaredoxin 4

1

0

High-throughput

0.513

High

494069

STPA
DNA-binding protein StpA

1

0

High-throughput

0.513

High

494072

YMJA
Uncharacterized protein YmjA

1

0

High-throughput

0.513

High

494074

YEEZ
Protein YeeZ

1

0

High-throughput

0.513

High

494075

SUHB
Nus factor SuhB

1

0

High-throughput

0.513

High

494080

RL16
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

494092

YCFH
Uncharacterized metal-dependent hydrolase YcfH

1

0

High-throughput

0.513

High

494093

SSPB
Stringent starvation protein B

1

0

High-throughput

0.513

High

494096

RL17
Large ribosomal subunit protein bL17

1

0

High-throughput

0.513

High

494100

RPOE
ECF RNA polymerase sigma-E factor

1

0

High-throughput

0.513

High

494104

TRKA
Trk system potassium uptake protein TrkA

1

0

High-throughput

0.513

High

494107

RSME
Ribosomal RNA small subunit methyltransferase E

1

0

High-throughput

0.513

High

494116

MINC
Septum site-determining protein MinC

1

0

High-throughput

0.513

High

494127

FMT
Methionyl-tRNA formyltransferase

1

0

High-throughput

0.513

High

494129

INTD
Prophage integrase IntD

1

0

High-throughput

0.513

High

494130

RECG
ATP-dependent DNA helicase RecG

1

0

High-throughput

0.513

High

494136

PABC
Aminodeoxychorismate lyase

1

0

High-throughput

0.513

High

494137

FENR
Flavodoxin/ferredoxin--NADP reductase

1

0

High-throughput

0.513

High

494143

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.513

High

494146

RHAD
Rhamnulose-1-phosphate aldolase

1

0

High-throughput

0.513

High

494156

RSMB
Ribosomal RNA small subunit methyltransferase B

1

0

High-throughput

0.513

High

494160

TAUD
Alpha-ketoglutarate-dependent taurine dioxygenase

1

0

High-throughput

0.513

High

494161

RLMJ
Ribosomal RNA large subunit methyltransferase J

1

0

High-throughput

0.513

High

494162

WAAF
Lipopolysaccharide heptosyltransferase 2

1

0

High-throughput

0.513

High

494166

YGGL
Uncharacterized protein YggL

1

0

High-throughput

0.513

High

494167

RSMC
Ribosomal RNA small subunit methyltransferase C

1

0

High-throughput

0.513

High

494168

ARFB
Peptidyl-tRNA hydrolase ArfB

1

0

High-throughput

0.513

High

494169

YHAK
Pirin-like protein YhaK

1

0

High-throughput

0.513

High

494170

OBG
GTPase ObgE/CgtA

1

0

High-throughput

0.513

High

494180

RL2
Large ribosomal subunit protein uL2

1

0

High-throughput

0.513

High

494181

UPPS
Ditrans,polycis-undecaprenyl-diphosphate synthase

1

0

High-throughput

0.513

High

494183

MDH
Malate dehydrogenase

1

0

High-throughput

0.513

High

494189

RSMI
Ribosomal RNA small subunit methyltransferase I

1

0

High-throughput

0.513

High

494192

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.513

High

494194

RLMKL
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase

1

0

High-throughput

0.513

High

494210

MTFA
Mlc titration factor A

1

0

High-throughput

0.513

High

494077

YIHD
Protein YihD

1

0

High-throughput

0.493

High

365809

RPOD
RNA polymerase sigma factor RpoD

1

1

High-throughput

0.484

High

490954

IHFB
Integration host factor subunit beta

1

3

High-throughput

0.484

High

491964

NUSB
Transcription antitermination protein NusB

1

1

High-throughput

0.484

High

494044

CSPD
Cold shock-like protein CspD

1

5

High-throughput

0.484

High

494053

DEAD
ATP-dependent RNA helicase DeaD

1

1

High-throughput

0.484

High

494054

ULAR
HTH-type transcriptional regulator UlaR

1

1

High-throughput

0.484

High

494063

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

1

High-throughput

0.484

High

494099

RPOH
RNA polymerase sigma factor RpoH

1

1

High-throughput

0.484

High

494121

RNE
Ribonuclease E

1

1

High-throughput

0.484

High

494059

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.479

High

458776

FDHF
Formate dehydrogenase H

1

1

High-throughput

0.479

High

494043

RIMJ
[Ribosomal protein uS5]-alanine N-acetyltransferase

1

1

Small-scale

0.479

High

490664

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

491535

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

494051

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

494108

RLME
Ribosomal RNA large subunit methyltransferase E

1

0

High-throughput

0.464

High

494109

RCSB
Transcriptional regulatory protein RcsB

1

0

High-throughput

0.464

High

393860

PBPA
Penicillin-binding protein 1A

1

0

High-throughput

0.458

High

395069

DNAA
Chromosomal replication initiator protein DnaA

1

0

High-throughput

0.458

High

491845

NAGB
Glucosamine-6-phosphate deaminase

1

0

High-throughput

0.458

High

494038

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

494041

YFBU
UPF0304 protein YfbU

1

0

High-throughput

0.458

High

494062

PCNB
Poly(A) polymerase I

1

0

High-throughput

0.458

High

494106

YHBY
RNA-binding protein YhbY

1

0

High-throughput

0.458

High

494110

LPXB
Lipid-A-disaccharide synthase

1

0

High-throughput

0.458

High

494117

PARE
DNA topoisomerase 4 subunit B

1

0

High-throughput

0.458

High

494123

MUKB
Chromosome partition protein MukB

1

0

High-throughput

0.458

High

494124

ISPA
Farnesyl diphosphate synthase

1

0

High-throughput

0.458

High

494142

GLNE
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1

0

High-throughput

0.458

High

494147

YJAG
Uncharacterized protein YjaG

1

0

High-throughput

0.458

High

494163

WBBJ
Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ

1

0

High-throughput

0.458

High

494187

GMHBB
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

1

0

High-throughput

0.458

High

494190

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

491312

HSCA
Chaperone protein HscA

1

1

High-throughput

0.445

High

494076

FIMB
Type 1 fimbriae regulatory protein FimB

1

1

High-throughput

0.442

High

479535

NARG
Respiratory nitrate reductase 1 alpha chain

1

1

High-throughput

0.437

High

449983

HIS2
Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.426

High

493024

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.426

High

494031

TIG
Trigger factor

1

0

High-throughput

0.426

High

494032

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.426

High

494039

PRMA
Ribosomal protein L11 methyltransferase

1

0

High-throughput

0.426

High

494048

FTSZ
Cell division protein FtsZ

1

0

High-throughput

0.426

High

494049

SOXS
Regulatory protein SoxS

1

0

High-throughput

0.426

High

494052

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

0

High-throughput

0.426

High

494073

YDJA
Putative NAD(P)H nitroreductase YdjA

1

0

High-throughput

0.426

High

494086

ELAB
Protein ElaB

1

0

High-throughput

0.426

High

494087

RIMO
Ribosomal protein uS12 methylthiotransferase RimO

1

0

High-throughput

0.426

High

494089

TSAE
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

1

0

High-throughput

0.426

High

494091

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.426

High

494113

RIML
Ribosomal-protein-serine acetyltransferase

1

0

High-throughput

0.426

High

494119

PNCA
Nicotinamidase

1

0

High-throughput

0.426

High

494133

MSYB
Acidic protein MsyB

1

0

High-throughput

0.426

High

494186

NFUA
Fe/S biogenesis protein NfuA

1

0

High-throughput

0.426

High

494219

ATOC
Regulatory protein AtoC

1

0

High-throughput

0.426

High

494064

FLAW
Flavodoxin 2

1

1

High-throughput

0.407

High

494202

YNAE
Uncharacterized protein YnaE

1

1

High-throughput

0.407

High

494205

YDFK
Cold shock protein YdfK

1

1

High-throughput

0.407

High

494215

HSCC
Chaperone protein HscC

1

3

High-throughput

0.407

High

494218

YDJF
Uncharacterized HTH-type transcriptional regulator YdjF

1

1

High-throughput

0.407

High

494028

RNPA
Ribonuclease P protein component

2

0

High-throughput

0.319

High

494033

YACL
UPF0231 protein YacL

2

0

High-throughput

0.307

High

494152

NIKE
Nickel import ATP-binding protein NikE

2

0

High-throughput

0.307

High

494176

END8
Endonuclease 8

2

0

High-throughput

0.307

High

494193

YBJX
Uncharacterized protein YbjX

2

0

High-throughput

0.307

High

469360

YCIH
Uncharacterized protein YciH

1

0

High-throughput

0.279

Low

479585

YJAA
Uncharacterized protein YjaA

1

0

High-throughput

0.279

Low

494030

SFSA
Sugar fermentation stimulation protein A

1

0

High-throughput

0.279

Low

494060

YCGL
Protein YcgL

1

0

High-throughput

0.279

Low

494079

YGIC
Putative acid--amine ligase YgiC

1

0

High-throughput

0.279

Low

494083

DEGS
Serine endoprotease DegS

1

0

High-throughput

0.279

Low

494084

DMA
DNA adenine methylase

1

0

High-throughput

0.279

Low

494085

DSBC
Thiol:disulfide interchange protein DsbC

1

0

High-throughput

0.279

Low

494094

UBIX
Flavin prenyltransferase UbiX

1

0

High-throughput

0.279

Low

494111

DAMX
Cell division protein DamX

1

0

High-throughput

0.279

Low

494112

GLPD
Aerobic glycerol-3-phosphate dehydrogenase

1

0

High-throughput

0.279

Low

494115

MURG
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

1

0

High-throughput

0.279

Low

494118

SPEA
Biosynthetic arginine decarboxylase

1

0

High-throughput

0.279

Low

494126

PRIC
Replication restart protein PriC

1

0

High-throughput

0.279

Low

494128

MCRA
Type IV methyl-directed restriction enzyme EcoKMcrA

1

0

High-throughput

0.279

Low

494135

DING
ATP-dependent DNA helicase DinG

1

0

High-throughput

0.279

Low

494139

RIBX
N-glycosidase YbiA

1

0

High-throughput

0.279

Low

494145

CBRC
UPF0167 protein CbrC

1

0

High-throughput

0.279

Low

494149

NRFG
Formate-dependent nitrite reductase complex subunit NrfG

1

0

High-throughput

0.279

Low

494151

LLDD
L-lactate dehydrogenase

1

0

High-throughput

0.279

Low

494153

HOFQ
DNA utilization protein HofQ

1

0

High-throughput

0.279

Low

494158

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

494171

YHBQ
UPF0213 protein YhbQ

1

0

High-throughput

0.279

Low

494172

FKBA
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

1

0

High-throughput

0.279

Low

494173

YHFS
Uncharacterized protein YhfS

1

0

High-throughput

0.279

Low

494174

YHFX
Uncharacterized protein YhfX

1

0

High-throughput

0.279

Low

494175

RTCB
RNA-splicing ligase RtcB

1

0

High-throughput

0.279

Low

494177

RATB
UPF0125 protein RatB

1

0

High-throughput

0.279

Low

494178

FLIZ
Regulator of sigma S factor FliZ

1

0

High-throughput

0.279

Low

494191

WCAK
Colanic acid biosynthesis protein WcaK

1

0

High-throughput

0.279

Low

494196

THIK
Thiamine kinase

1

0

High-throughput

0.279

Low

494198

BLUR
HTH-type transcriptional repressor BluR

1

0

High-throughput

0.279

Low

494199

YCGM
Oxaloacetate tautomerase YcgM

1

0

High-throughput

0.279

Low

494204

YNEG
Uncharacterized protein YneG

1

0

High-throughput

0.279

Low

494207

YEAO
Uncharacterized protein YeaO

1

0

High-throughput

0.279

Low

494209

YEDK
Abasic site processing protein YedK

1

0

High-throughput

0.279

Low

494211

DSBG
Thiol:disulfide interchange protein DsbG

1

0

High-throughput

0.279

Low

494212

MURR
HTH-type transcriptional regulator MurR

1

0

High-throughput

0.279

Low

494213

EUTJ
Ethanolamine utilization protein EutJ

1

0

High-throughput

0.279

Low

494214

YGAV
HTH-type transcriptional regulator YgaV

1

0

High-throughput

0.279

Low

494221

YAFO
mRNA interferase toxin YafO

1

0

High-throughput

0.279

Low

494222

YBCN
Uncharacterized protein YbcN

1

0

High-throughput

0.279

Low

494203

YDDJ
Putative protein YddJ

1

0

High-throughput

0.269

Low

494078

YGGE
Uncharacterized protein YggE

1

0

High-throughput

0.261

Low

492027

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.253

Low

494035

TRMB
tRNA

1

0

High-throughput

0.253

Low

494042

YBGC
Acyl-CoA thioester hydrolase YbgC

1

0

High-throughput

0.253

Low

494131

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

1

0

High-throughput

0.253

Low

494159

DCTR
HTH-type transcriptional regulator DctR

1

0

High-throughput

0.253

Low

494220

YGCP
Uncharacterized protein YgcP

1

0

High-throughput

0.253

Low

494132

YIDC
Membrane protein insertase YidC

1

0

Small-scale

0.249

Low

494138

LHR
Lhr helicase/uracil glycosylase

1

0

High-throughput

0.249

Low

494144

POTF
Putrescine-binding periplasmic protein PotF

1

0

High-throughput

0.249

Low

494155

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

0

High-throughput

0.249

Low

494164

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

494179

CSIE
Stationary phase-inducible protein CsiE

1

0

High-throughput

0.249

Low

494217

YBAY
Uncharacterized lipoprotein YbaY

1

0

High-throughput

0.249

Low

418554

NLPA
Lipoprotein 28

1

0

High-throughput

0.232

Low

449928

DICA
HTH-type transcriptional regulator DicA

1

0

High-throughput

0.232

Low

494071

SFSB
Sugar fermentation stimulation protein B

1

0

High-throughput

0.232

Low

494082

MAZE
Antitoxin MazE

1

0

High-throughput

0.232

Low

494088

ENTC
Isochorismate synthase EntC

1

0

High-throughput

0.232

Low

494140

INSZ
Putative transposase InsZ

1

0

High-throughput

0.232

Low

494141

PSUK
Pseudouridine kinase

1

0

High-throughput

0.232

Low

494185

ISPF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

1

0

High-throughput

0.232

Low

494188

YGHW
Uncharacterized protein YghW

1

0

High-throughput

0.232

Low

494195

SXY
Protein Sxy

1

0

High-throughput

0.232

Low

494200

YCJX
Ras-like GTPase YcjX

1

0

High-throughput

0.232

Low

494201

RACR
DNA-binding transcriptional repressor RacR

1

0

High-throughput

0.232

Low

494206

YDFX
Protein YdfX

1

0

High-throughput

0.232

Low

494216

YDHW
Uncharacterized protein YdhW

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025