Interactor 1: CASP4 (P70343)
Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
Gene: CASP4
Interactor 2: GSDMD (Q9D8T2)
Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (mGSDMD-NTD) (p30); Gasdermin-D, C-terminal (GSDMD-CT) (mGSDMD-CTD) (p20); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]
Gene: GSDMD
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.44 | 1.00 | 0.666 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26375259 |
| Identification Methods | protease assay |
| Interaction Type | direct interaction, protein cleavage |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Gasdermin_C~Peptidase_C14 |
| Common GO terms | GO:0005829 - cytosol GO:0032731 - positive regulation of interleukin-1 beta production GO:0045087 - innate immune response GO:0050729 - positive regulation of inflammatory response GO:0050830 - defense response to Gram-positive bacterium and 2 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
