Protein: GSDMD
Gasdermin-D (Gasdermin domain-containing protein 1) [Cleaved into: Gasdermin-D, N-terminal (GSDMD-NT) (hGSDMD-NTD); Gasdermin-D, C-terminal (GSDMD-CT) (hGSDMD-CTD); Gasdermin-D, p13 (Gasdermin-D, 13 kDa) (13 kDa GSDMD); Gasdermin-D, p40]

Gene: GSDMD
Organism: Homo sapiens
Interactions: 36
UniProt ID: P57764

Gene Ontology (top 5):
GO:0001786 - phosphatidylserine binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712845

CASP1
Caspase-1

1

3

Small-scale

0.765

High

945518

KCTD6
BTB/POZ domain-containing protein KCTD6

4

0

High-throughput

0.668

High

885690

CASP4
Caspase-4

1

3

Small-scale

0.666

High

945510

CASP8
Caspase-8

1

3

Small-scale

0.618

High

680828

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.580

High

945515

KAISO
Transcriptional regulator Kaiso

2

0

High-throughput

0.580

High

945517

LPP60
60 kDa lysophospholipase

2

0

High-throughput

0.580

High

248858

GSDME
Gasdermin-E

1

1

High-throughput

0.575

High

640137

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.571

High

945521

ZN558
Zinc finger protein 558

2

1

High-throughput

0.553

High

945528

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

1

High-throughput

0.536

High

461324

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

468227

HS90B
Heat shock protein HSP 90-beta

1

1

Small-scale

0.479

High

945516

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

945512

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

334165

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

Small-scale

0.458

High

378554

IL1B
Interleukin-1 beta

1

0

Small-scale

0.458

High

861538

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.458

High

945511

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

945529

IRAK3
Interleukin-1 receptor-associated kinase 3

1

0

Small-scale

0.458

High

563499

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

896361

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.445

High

945508

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.445

High

945520

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

945522

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

893780

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

945514

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

466881

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.426

High

945513

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

945524

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

945525

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

945526

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

945527

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

945519

SFXN5
Sideroflexin-5

1

1

High-throughput

0.407

High

945523

ZN426
Zinc finger protein 426

2

0

High-throughput

0.316

High

945509

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025