Protein: SRF
Serum response factor (SRF)

Gene: SRF
Organism: Homo sapiens
Interactions: 107
UniProt ID: P11831

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 - branching involved in blood vessel morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

515540

SRF
Serum response factor

3

19

Small-scale

0.845

High

515614

MRTFA
Myocardin-related transcription factor A

5

5

Small-scale

0.709

High

515600

HMBX1
Homeobox-containing protein 1

1

4

High-throughput

0.691

High

515606

MYCD
Myocardin

4

5

Small-scale

0.686

High

515551

ELK1
ETS domain-containing protein Elk-1

3

6

Small-scale

0.651

High

515567

GATA4
Transcription factor GATA-4

2

3

Small-scale

0.646

High

515557

ELK4
ETS domain-containing protein Elk-4

3

6

Small-scale

0.637

High

515544

MYOG
Myogenin

2

7

Small-scale

0.625

High

515547

CEBPB
CCAAT/enhancer-binding protein beta

2

3

Small-scale

0.625

High

515611

CBP
CREB-binding protein

2

5

Small-scale

0.620

High

515577

PRKDC
DNA-dependent protein kinase catalytic subunit

2

1

Small-scale

0.619

High

515563

CUX1
Homeobox protein cut-like 1

1

4

High-throughput

0.618

High

515607

SIX5
Homeobox protein SIX5

1

3

High-throughput

0.618

High

515615

NKX31
Homeobox protein Nkx-3.1

1

5

Small-scale

0.618

High

515618

ZHX3
Zinc fingers and homeoboxes protein 3

1

1

High-throughput

0.618

High

515624

SIX4
Homeobox protein SIX4

1

2

High-throughput

0.618

High

515630

ZHX2
Zinc fingers and homeoboxes protein 2

1

1

High-throughput

0.618

High

515626

MRTFB
Myocardin-related transcription factor B

2

5

Small-scale

0.612

High

515570

SMCA4
Transcription activator BRG1

2

14

Small-scale

0.584

High

515558

TEAD1
Transcriptional enhancer factor TEF-1

1

2

Small-scale

0.578

High

515561

T2FA
General transcription factor IIF subunit 1

2

0

Small-scale

0.569

High

515559

PML
Protein PML

1

1

Small-scale

0.561

High

515573

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.561

High

515578

FOXK1
Forkhead box protein K1

1

2

Small-scale

0.561

High

515591

FHL2
Four and a half LIM domains protein 2

1

1

Small-scale

0.561

High

515576

GTF2I
General transcription factor II-I

2

0

Small-scale

0.560

High

515543

MYOD1
Myoblast determination protein 1

1

6

Small-scale

0.552

High

320804

HS74L
Heat shock 70 kDa protein 4L

1

5

High-throughput

0.536

High

455032

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

515552

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

515579

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.536

High

515585

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.536

High

515589

NFYC
Nuclear transcription factor Y subunit gamma

1

1

High-throughput

0.536

High

515603

VRK3
Serine/threonine-protein kinase VRK3

1

2

High-throughput

0.536

High

515622

UBIP1
Upstream-binding protein 1

1

2

High-throughput

0.536

High

515623

TRPS1
Zinc finger transcription factor Trps1

1

4

High-throughput

0.536

High

515628

TTF2
Transcription termination factor 2

1

11

High-throughput

0.536

High

183058

KDM6A
Lysine-specific demethylase 6A

1

0

Small-scale

0.529

High

487888

RARA
Retinoic acid receptor alpha

1

3

Small-scale

0.527

High

515549

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

1

Small-scale

0.527

High

515555

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.527

High

515568

RXRG
Retinoic acid receptor RXR-gamma

1

2

Small-scale

0.527

High

515595

NCOA1
Nuclear receptor coactivator 1

1

5

Small-scale

0.527

High

515629

NCOR2
Nuclear receptor corepressor 2

1

2

Small-scale

0.527

High

515560

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.518

High

515590

CIRBP
Cold-inducible RNA-binding protein

1

0

High-throughput

0.518

High

266527

GPC4
Glypican-4

1

0

High-throughput

0.513

High

268384

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

486374

RO60
RNA-binding protein RO60

1

0

High-throughput

0.513

High

515546

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.513

High

515550

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

515556

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.513

High

515569

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

515601

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.513

High

515610

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.513

High

515627

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.513

High

515594

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.504

High

234700

ZIC3
Zinc finger protein ZIC 3

1

1

Small-scale

0.501

High

434914

SP1
Transcription factor Sp1

1

8

Small-scale

0.501

High

515554

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

Small-scale

0.501

High

515572

FOXG1
Forkhead box protein G1

1

2

Small-scale

0.501

High

515574

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.501

High

515575

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.501

High

515580

FLI1
Friend leukemia integration 1 transcription factor

1

6

Small-scale

0.501

High

515582

TF65
Transcription factor p65

1

4

Small-scale

0.501

High

515583

REL
Proto-oncogene c-Rel

1

4

Small-scale

0.501

High

515587

FHL1
Four and a half LIM domains protein 1

1

1

Small-scale

0.501

High

515592

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.501

High

515542

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.493

High

515553

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.481

High

515609

SRFB1
Serum response factor-binding protein 1

1

0

Small-scale

0.480

High

515612

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.480

High

167325

SMAD7
Mothers against decapentaplegic homolog 7

1

3

Small-scale

0.479

High

177180

HDAC3
Histone deacetylase 3

1

5

Small-scale

0.479

High

229781

ZN292
Zinc finger protein 292

1

1

High-throughput

0.479

High

326402

SNAI1
Zinc finger protein SNAI1

1

1

Small-scale

0.479

High

515545

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.479

High

515548

EGR1
Early growth response protein 1

1

3

Small-scale

0.479

High

515562

ZEB1
Zinc finger E-box-binding homeobox 1

1

2

High-throughput

0.479

High

515566

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

515581

SP2
Transcription factor Sp2

1

7

High-throughput

0.479

High

515584

SSRP1
FACT complex subunit SSRP1

1

4

Small-scale

0.479

High

515586

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

5

Small-scale

0.479

High

515593

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.479

High

515597

ARID2
AT-rich interactive domain-containing protein 2

1

2

High-throughput

0.479

High

515598

Z518A
Zinc finger protein 518A

1

1

High-throughput

0.479

High

515599

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

1

High-throughput

0.479

High

515602

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.479

High

515604

FOXP4
Forkhead box protein P4

1

3

High-throughput

0.479

High

515605

ARI3B
AT-rich interactive domain-containing protein 3B

1

2

High-throughput

0.479

High

515608

PHC3
Polyhomeotic-like protein 3

1

1

High-throughput

0.479

High

515616

EPC1
Enhancer of polycomb homolog 1

1

1

Small-scale

0.479

High

515620

TF7L2
Transcription factor 7-like 2

1

6

High-throughput

0.479

High

446001

CD63
CD63 antigen

1

0

Small-scale

0.460

High

515613

TRI63
E3 ubiquitin-protein ligase TRIM63

1

0

Small-scale

0.460

High

515596

BCORL
BCL-6 corepressor-like protein 1

1

0

High-throughput

0.458

High

515619

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

515625

GMEB2
Glucocorticoid modulatory element-binding protein 2

1

0

High-throughput

0.458

High

515565

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

1

High-throughput

0.445

High

515588

CASP
Protein CASP

1

2

High-throughput

0.445

High

515541

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

515564

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

515571

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

515617

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

515621

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.279

Low

380930

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024