Protein: CASP4
Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]

Gene: CASP4
Organism: Homo sapiens
Interactions: 58
UniProt ID: P49662

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0004197 - cysteine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

885693

IL18
Interleukin-18

3

3

Small-scale

0.818

High

885687

CASP5
Caspase-5

2

18

High-throughput

0.811

High

885715

IL37
Interleukin-37

1

6

Small-scale

0.710

High

885690

GSDMD
Gasdermin-D

1

3

Small-scale

0.666

High

885696

CASP8
Caspase-8

1

17

Small-scale

0.647

High

885704

CASPA
Caspase-10

1

17

Small-scale

0.647

High

161700

APAF
Apoptotic protease-activating factor 1

1

5

Small-scale

0.618

High

729525

CASPE
Caspase-14

1

18

Small-scale

0.618

High

885691

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

Small-scale

0.618

High

885711

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

20

Small-scale

0.618

High

885720

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.618

High

885698

RHG44
Rho GTPase-activating protein 44

1

3

High-throughput

0.536

High

772673

MYH9
Myosin-9

1

0

High-throughput

0.518

High

333969

SMC2
Structural maintenance of chromosomes protein 2

1

3

High-throughput

0.515

High

442268

GELS
Gelsolin

1

3

High-throughput

0.515

High

667647

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.515

High

831962

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.515

High

885688

MSH6
DNA mismatch repair protein Msh6

1

2

High-throughput

0.515

High

885695

SMC1A
Structural maintenance of chromosomes protein 1A

1

3

High-throughput

0.515

High

885703

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.515

High

885705

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

3

High-throughput

0.515

High

885710

GHC1
Mitochondrial glutamate carrier 1

1

4

High-throughput

0.515

High

885719

SMC3
Structural maintenance of chromosomes protein 3

1

3

High-throughput

0.515

High

885722

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

1

High-throughput

0.515

High

885708

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

0

High-throughput

0.513

High

885718

CNOT8
CCR4-NOT transcription complex subunit 8

1

0

High-throughput

0.513

High

421716

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

885685

SPB9
Serpin B9

1

8

Small-scale

0.501

High

319524

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.493

High

633626

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.493

High

885699

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.493

High

885700

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.493

High

885701

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.493

High

885702

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.493

High

885712

CNBP1
Beta-catenin-interacting protein 1

1

0

High-throughput

0.493

High

885724

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.493

High

289461

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

3

High-throughput

0.479

High

539045

UMPS
Uridine 5'-monophosphate synthase

1

1

High-throughput

0.479

High

606422

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

640807

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.479

High

885689

TXTP
Tricarboxylate transport protein, mitochondrial

1

4

High-throughput

0.479

High

885692

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.479

High

885694

DCTN1
Dynactin subunit 1

1

4

High-throughput

0.479

High

885713

SMC4
Structural maintenance of chromosomes protein 4

1

4

High-throughput

0.479

High

885714

MDN1
Midasin

1

2

High-throughput

0.479

High

885717

HACD3
Very-long-chain

1

4

High-throughput

0.479

High

885723

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

158149

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

193873

XLRS1
Retinoschisin

1

0

Small-scale

0.458

High

885686

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.458

High

885697

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.458

High

885709

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.458

High

885721

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.458

High

485583

RU2A
U2 small nuclear ribonucleoprotein A'

1

2

High-throughput

0.437

High

885706

LSM10
U7 snRNA-associated Sm-like protein LSm10

1

1

High-throughput

0.437

High

885707

ELF4
ETS-related transcription factor Elf-4

1

0

High-throughput

0.282

High

885716

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.249

Low

248201

NDK8
Putative nucleoside diphosphate kinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025