Protein: CASP1
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]

Gene: CASP1
Organism: Homo sapiens
Interactions: 107
UniProt ID: P29466

Gene Ontology (top 5):
GO:0002221 - pattern recognition receptor signaling pathway
GO:0004175 - endopeptidase activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712900

ASC
Apoptosis-associated speck-like protein containing a CARD

13

16

Small-scale

0.978

High

378550

IL1B
Interleukin-1 beta

6

7

Small-scale

0.940

High

712893

NLRC4
NLR family CARD domain-containing protein 4

6

20

Small-scale

0.938

High

214390

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

6

8

Small-scale

0.935

High

712865

IL18
Interleukin-18

5

3

Small-scale

0.908

High

712829

CASP1
Caspase-1

5

17

Small-scale

0.905

High

712889

NLRP1
NACHT, LRR and PYD domains-containing protein 1

4

20

Small-scale

0.881

High

712904

CARD8
Caspase recruitment domain-containing protein 8

3

10

Small-scale

0.821

High

712892

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

20

Small-scale

0.789

High

712872

CAR16
Caspase recruitment domain-containing protein 16

2

17

Small-scale

0.789

High

712845

GSDMD
Gasdermin-D

1

3

Small-scale

0.765

High

712873

CAR17
Putative caspase recruitment domain-containing protein 17P

1

11

Small-scale

0.733

High

712897

IL37
Interleukin-37

1

6

Small-scale

0.710

High

712851

VAC14
Protein VAC14 homolog

4

2

High-throughput

0.705

High

712886

NLRP3
NACHT, LRR and PYD domains-containing protein 3

5

20

Small-scale

0.702

High

712844

CAR18
Caspase recruitment domain-containing protein 18

1

11

Small-scale

0.701

High

194778

MEFV
Pyrin

4

6

Small-scale

0.686

High

712842

KIF11
Kinesin-like protein KIF11

3

1

High-throughput

0.667

High

712898

PI4KB
Phosphatidylinositol 4-kinase beta

3

1

High-throughput

0.667

High

712905

KIF3A
Kinesin-like protein KIF3A

3

1

High-throughput

0.667

High

240834

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.665

High

712867

CASP8
Caspase-8

1

17

Small-scale

0.647

High

712883

CASPA
Caspase-10

1

17

Small-scale

0.647

High

712860

GAB1
GRB2-associated-binding protein 1

3

0

High-throughput

0.638

High

712871

ARI4B
AT-rich interactive domain-containing protein 4B

3

0

High-throughput

0.638

High

712896

FMN2
Formin-2

3

0

High-throughput

0.638

High

378476

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.631

High

712830

CASPE
Caspase-14

1

17

Small-scale

0.618

High

712850

B2CL1
Bcl-2-like protein 1

1

8

Small-scale

0.618

High

712861

BIRC3
Baculoviral IAP repeat-containing protein 3

1

20

Small-scale

0.618

High

712884

RNF34
E3 ubiquitin-protein ligase RNF34

1

20

Small-scale

0.618

High

712903

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.618

High

344434

IL33
Interleukin-33

2

2

Small-scale

0.608

High

712902

PLCL2
Inactive phospholipase C-like protein 2

2

0

High-throughput

0.602

High

712846

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

0

Small-scale

0.599

High

606281

CEBPB
CCAAT/enhancer-binding protein beta

2

3

Small-scale

0.584

High

712869

IF16
Gamma-interferon-inducible protein 16

2

1

Small-scale

0.584

High

712832

CASP3
Caspase-3

1

17

Small-scale

0.575

High

712885

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.561

High

712857

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.554

High

362828

EGFR
Epidermal growth factor receptor

1

6

Small-scale

0.550

High

563256

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

712880

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

20

Small-scale

0.515

High

256445

TOM1
Target of Myb1 membrane trafficking protein

1

1

High-throughput

0.515

High

421558

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

570362

GFAP
Glial fibrillary acidic protein

1

5

High-throughput

0.515

High

699602

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.515

High

712833

HD
Huntingtin

1

4

High-throughput

0.515

High

712843

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

712849

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.515

High

712864

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.515

High

712852

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.513

High

486991

PARP1
Poly [ADP-ribose] polymerase 1

1

9

Small-scale

0.501

High

505860

PA24B
Cytosolic phospholipase A2 beta

1

7

Small-scale

0.501

High

529155

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.501

High

712838

SPB9
Serpin B9

1

8

Small-scale

0.501

High

712839

BAP31
B-cell receptor-associated protein 31

1

1

Small-scale

0.501

High

712877

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

Small-scale

0.501

High

166122

AIM2
Interferon-inducible protein AIM2

1

1

Small-scale

0.494

High

154525

PLPP1
Phospholipid phosphatase 1

1

0

High-throughput

0.493

High

712837

PSN2
Presenilin-2

1

0

High-throughput

0.493

High

712859

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.493

High

712887

TM2D1
TM2 domain-containing protein 1

1

0

High-throughput

0.493

High

712899

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

259494

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

436804

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.479

High

478452

FGF2
Fibroblast growth factor 2

1

1

Small-scale

0.479

High

612885

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

631079

RAB5A
Ras-related protein Rab-5A

1

3

Small-scale

0.479

High

712831

BRCA1
Breast cancer type 1 susceptibility protein

1

5

Small-scale

0.479

High

712836

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

712840

XK
Endoplasmic reticulum membrane adapter protein XK

1

1

Small-scale

0.479

High

712847

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

20

Small-scale

0.479

High

712848

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.479

High

712853

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

712854

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

712856

FLII
Protein flightless-1 homolog

1

3

Small-scale

0.479

High

712858

TIF1B
Transcription intermediary factor 1-beta

1

8

Small-scale

0.479

High

712862

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

712863

CUL3
Cullin-3

1

5

Small-scale

0.479

High

712866

KEAP1
Kelch-like ECH-associated protein 1

1

3

Small-scale

0.479

High

712868

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

712870

TR16L
Tripartite motif-containing protein 16-like protein

1

7

Small-scale

0.479

High

712875

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

712878

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

20

Small-scale

0.479

High

712879

NEK7
Serine/threonine-protein kinase Nek7

1

5

Small-scale

0.479

High

712882

ESR2
Estrogen receptor beta

1

5

Small-scale

0.479

High

712888

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

Small-scale

0.479

High

712890

SHRPN
Sharpin

1

1

Small-scale

0.479

High

712891

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

Small-scale

0.479

High

712894

IFT57
Intraflagellar transport protein 57 homolog

1

2

Small-scale

0.479

High

712895

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

20

Small-scale

0.479

High

712901

APC10
Anaphase-promoting complex subunit 10

1

2

Small-scale

0.479

High

360175

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.458

High

437101

K2C8
Keratin, type II cytoskeletal 8

1

0

Small-scale

0.458

High

446680

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

712855

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

712881

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

0

Small-scale

0.458

High

518732

GRAB
Granzyme B

1

12

Small-scale

0.445

High

712834

KSYK
Tyrosine-protein kinase SYK

1

7

Small-scale

0.445

High

712835

PA24A
Cytosolic phospholipase A2

1

7

Small-scale

0.445

High

712841

GDIR1
Rho GDP-dissociation inhibitor 1

1

8

Small-scale

0.445

High

712874

A16L1
Autophagy-related protein 16-1

1

4

Small-scale

0.445

High

712876

MAVS
Mitochondrial antiviral-signaling protein

1

4

Small-scale

0.445

High

261096

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

301354

WFS1
Wolframin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025