HitPredict

Interactor 1: CPSF1 (Q10570)
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
Gene: CPSF1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29395067, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1443 Hs			1 551
+	Hs
		1014166 CPSF1_HUMAN (1-1443): 0: 1602: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		1014197 CPSF1_HUMAN (1-1443): 0: 1602: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Mm
		1112249 DDB1_MOUSE (584-1438): 1.41e-146: 479: 15.88		SMCA2_MOUSE (137-551): 5.16e-46: 175: 14.44
+	Mm
		1111918 DDB1_MOUSE (584-1438): 1.41e-146: 479: 15.88		SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30
+	Sc
		376929 RSE1_YEAST (1-726): 3.88e-97: 344: 14.10		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96