Protein: CBX2
Chromobox protein homolog 2

Gene: CBX2
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q14781

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000791 - euchromatin
GO:0000792 - heterochromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1132226

RING2
E3 ubiquitin-protein ligase RING2

10

20

Small-scale

0.976

High

766090

PCGF2
Polycomb group RING finger protein 2

10

20

Small-scale

0.974

High

765521

BMI1
Polycomb complex protein BMI-1

10

20

Small-scale

0.973

High

1055806

RING1
E3 ubiquitin-protein ligase RING1

5

20

Small-scale

0.924

High

998322

H31
Histone H3.1

4

20

Small-scale

0.884

High

129730

CBX4
E3 SUMO-protein ligase CBX4

4

17

Small-scale

0.873

High

1016864

H33
Histone H3.3

3

20

Small-scale

0.843

High

980771

H2B1C
Histone H2B type 1-C/E/F/G/I

3

20

High-throughput

0.817

High

1132239

CBX8
Chromobox protein homolog 8

2

18

Small-scale

0.754

High

1132193

H31T
Histone H3.1t

2

20

Small-scale

0.746

High

1132205

H32
Histone H3.2

1

20

Small-scale

0.740

High

1006845

PHC1
Polyhomeotic-like protein 1

6

20

Small-scale

0.733

High

1132211

PHC2
Polyhomeotic-like protein 2

6

20

Small-scale

0.732

High

995036

CSK2B
Casein kinase II subunit beta

5

4

Small-scale

0.712

High

1132228

MDFI
MyoD family inhibitor

4

1

High-throughput

0.703

High

960424

PSME3
Proteasome activator complex subunit 3

4

1

High-throughput

0.699

High

418988

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.691

High

501986

H2AZ
Histone H2A.Z

1

20

High-throughput

0.691

High

1132194

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1132218

PHC3
Polyhomeotic-like protein 3

4

20

Small-scale

0.686

High

1132192

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

3

4

High-throughput

0.675

High

1132251

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

20

High-throughput

0.628

High

1132216

RYBP
RING1 and YY1-binding protein

2

12

Small-scale

0.624

High

338841

CBX6
Chromobox protein homolog 6

1

19

High-throughput

0.618

High

754846

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

883541

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

1132189

CBX2
Chromobox protein homolog 2

1

18

Small-scale

0.618

High

1132195

PCGF3
Polycomb group RING finger protein 3

1

20

High-throughput

0.618

High

1132208

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.618

High

1132232

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.618

High

1132233

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.618

High

1132202

DHX57
Putative ATP-dependent RNA helicase DHX57

3

9

High-throughput

0.616

High

487322

PARP1
Poly [ADP-ribose] polymerase 1

2

16

High-throughput

0.611

High

625382

CSK22
Casein kinase II subunit alpha'

2

10

Small-scale

0.611

High

997718

CSK21
Casein kinase II subunit alpha

2

10

Small-scale

0.611

High

1132217

BOLL
Protein boule-like

2

4

High-throughput

0.606

High

612641

RL7
Large ribosomal subunit protein uL30

2

0

High-throughput

0.602

High

1132221

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

10

Small-scale

0.584

High

1132246

SCML1
Sex comb on midleg-like protein 1

2

20

High-throughput

0.584

High

1132204

RBPS2
RNA-binding protein with multiple splicing 2

2

0

High-throughput

0.580

High

515839

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

4

High-throughput

0.573

High

948318

KR122
Keratin-associated protein 12-2

2

10

High-throughput

0.553

High

949537

KR123
Keratin-associated protein 12-3

2

1

High-throughput

0.553

High

1132234

KRA44
Keratin-associated protein 4-4

2

10

High-throughput

0.553

High

1132222

TRI63
E3 ubiquitin-protein ligase TRIM63

1

14

High-throughput

0.541

High

1132235

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

287926

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

5

High-throughput

0.536

High

447026

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

542023

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

601674

HMGA1
High mobility group protein HMG-I/HMG-Y

1

5

High-throughput

0.536

High

634445

LMNB1
Lamin-B1

1

7

High-throughput

0.536

High

872333

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.536

High

979662

H4
Histone H4

1

15

High-throughput

0.536

High

1005866

GTF2I
General transcription factor II-I

1

2

High-throughput

0.536

High

1013056

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

7

High-throughput

0.536

High

1035505

CENPE
Centromere-associated protein E

1

2

High-throughput

0.536

High

1065197

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1132191

NUMA1
Nuclear mitotic apparatus protein 1

1

11

High-throughput

0.536

High

1132196

DCAF6
DDB1- and CUL4-associated factor 6

1

14

High-throughput

0.536

High

1132206

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.536

High

1132224

SCMH1
Polycomb protein SCMH1

1

20

High-throughput

0.536

High

1132230

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

1

High-throughput

0.536

High

1132236

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

5

High-throughput

0.536

High

1132242

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

1

20

High-throughput

0.536

High

1132252

KDM3A
Lysine-specific demethylase 3A

1

15

High-throughput

0.536

High

505319

KRA23
Keratin-associated protein 2-3

1

10

High-throughput

0.523

High

950250

KR107
Keratin-associated protein 10-7

1

8

High-throughput

0.523

High

950760

KR109
Keratin-associated protein 10-9

1

9

High-throughput

0.523

High

929786

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

1025099

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.515

High

1096003

TADBP
TAR DNA-binding protein 43

1

3

High-throughput

0.515

High

1132200

Q6FHY5
MEOX2 protein

1

4

High-throughput

0.515

High

1132207

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1132253

TF3C3
General transcription factor 3C polypeptide 3

1

1

High-throughput

0.515

High

1132229

KR412
Keratin-associated protein 4-12

1

10

High-throughput

0.494

High

176005

TRNK1
TPR and ankyrin repeat-containing protein 1

1

1

High-throughput

0.489

High

630275

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

3

High-throughput

0.489

High

1132198

CD158
Coiled-coil domain-containing protein 158

1

2

High-throughput

0.489

High

1132199

RN213
E3 ubiquitin-protein ligase RNF213

1

2

High-throughput

0.489

High

1132214

DI3L2
DIS3-like exonuclease 2

1

2

High-throughput

0.489

High

1132247

ANR26
Ankyrin repeat domain-containing protein 26

1

5

High-throughput

0.489

High

893866

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.481

High

142997

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

190912

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

254370

CC14B
Dual specificity protein phosphatase CDC14B

1

4

High-throughput

0.479

High

282718

E2F6
Transcription factor E2F6

1

6

High-throughput

0.479

High

342874

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

High-throughput

0.479

High

372045

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

400844

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

473991

NFIC
Nuclear factor 1 C-type

1

19

High-throughput

0.479

High

697117

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

907430

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

8

Small-scale

0.479

High

992176

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.479

High

1024579

VIGLN
Vigilin

1

11

High-throughput

0.479

High

1033679

PO5F1
POU domain, class 5, transcription factor 1

1

5

High-throughput

0.479

High

1087742

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1129590

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

High-throughput

0.479

High

1132190

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1132197

BCORL
BCL-6 corepressor-like protein 1

1

13

High-throughput

0.479

High

1132203

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

1132209

MGAP
MAX gene-associated protein

1

10

High-throughput

0.479

High

1132212

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1132213

YAF2
YY1-associated factor 2

1

12

High-throughput

0.479

High

1132215

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

15

Small-scale

0.479

High

1132219

KDM2B
Lysine-specific demethylase 2B

1

10

High-throughput

0.479

High

1132223

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.479

High

1132227

FEV
Protein FEV

1

2

High-throughput

0.479

High

1132237

NANOG
Homeobox protein NANOG

1

6

High-throughput

0.479

High

1132240

MDN1
Midasin

1

1

Small-scale

0.479

High

1132241

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1132244

DAXX
Death domain-associated protein 6

1

5

Small-scale

0.479

High

1132248

SCML2
Sex comb on midleg-like protein 2

1

20

Small-scale

0.479

High

1132250

ZN330
Zinc finger protein 330

1

4

High-throughput

0.479

High

1132254

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.479

High

109404

G5E9A7
DM1 locus, WD repeat containing

1

10

High-throughput

0.470

High

363298

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

703140

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

949358

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

1132249

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

503582

TFPT
TCF3 fusion partner

1

1

High-throughput

0.445

High

649316

H1T
Histone H1t

1

15

High-throughput

0.445

High

686164

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.445

High

969225

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.445

High

985169

RL10A
Large ribosomal subunit protein uL1

1

2

High-throughput

0.445

High

985663

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.445

High

1034572

AK17A
A-kinase anchor protein 17A

1

4

High-throughput

0.445

High

1128004

DHX8
ATP-dependent RNA helicase DHX8

1

4

High-throughput

0.445

High

1132201

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

1132220

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

5

High-throughput

0.445

High

1132245

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.445

High

949694

KR101
Keratin-associated protein 10-1

1

9

High-throughput

0.439

High

949876

KR103
Keratin-associated protein 10-3

1

10

High-throughput

0.439

High

1132238

FBRS
Probable fibrosin-1

1

6

High-throughput

0.437

High

1132231

UTP23
rRNA-processing protein UTP23 homolog

1

2

High-throughput

0.407

High

70209

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1132243

SPAT7
Spermatogenesis-associated protein 7

1

0

High-throughput

0.279

Low

1132255

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

47330

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

105942

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1132225

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

844775

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

1132210

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025