HitPredict

Interactor 1: ARP8 (Q12386)
Actin-like protein ARP8
Gene: ARP8

Interactor 2: RUVB2 (Q12464)
RuvB-like protein 2 (RUVBL2) (EC 3.6.4.12) (TIP49-homology protein 2) (TIP49b homolog)
Gene: RVB2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	10952318, 26831523, 16554755, 16429126, 30120252, 15607974, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~TIP49
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006281 - DNA repair GO:0006338 - chromatin remodeling GO:0006355 - regulation of DNA-templated transcription and 1 others more... GO:0031011 - Ino80 complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 881 Sc			1 471
+	Sc
		978055 ARP8_YEAST (1-881): 0: 789: 100.00		RUVB1_YEAST (8-448): 0: 624: 41.10
+	Hs
		1334077 ARP8_HUMAN (264-881): 0: 559: 24.37		RUVB2_HUMAN (4-451): 0: 680: 68.15
+	Hs
		1334078 ARP8_HUMAN (264-881): 0: 559: 24.37		RUVB1_HUMAN (10-448): 0: 658: 41.72
+	Mm
		888098 ARP8_MOUSE (264-881): 0: 552: 24.07		RUVB1_MOUSE (10-448): 0: 658: 41.72
+	Sc
		887725 ACT_YEAST (730-877): 3.32e-52: 188: 15.66		RUVB2_YEAST (1-471): 0: 707: 100.00
+	Hs
		892121 ACTB_HUMAN (730-877): 6.7e-56: 199: 15.66		RUVB2_HUMAN (4-451): 0: 680: 68.15
+	Hs
		930057 ACTG_HUMAN (730-877): 6.7e-56: 199: 15.66		RUVB2_HUMAN (4-451): 0: 680: 68.15
+	Hs
		932462 ACTC_HUMAN (706-877): 1.36e-54: 195: 14.15		RUVB2_HUMAN (4-451): 0: 680: 68.15
+	Hs
		892123 ACTB_HUMAN (730-877): 6.7e-56: 199: 15.66		RUVB1_HUMAN (10-448): 0: 658: 41.72
+	Hs
		930058 ACTG_HUMAN (730-877): 6.7e-56: 199: 15.66		RUVB1_HUMAN (10-448): 0: 658: 41.72
+	Hs
		932463 ACTC_HUMAN (706-877): 1.36e-54: 195: 14.15		RUVB1_HUMAN (10-448): 0: 658: 41.72
+	Dm
		501453 ACT5_DROME (730-877): 1.06e-54: 196: 15.06		RUVB1_DROME (10-448): 0: 622: 40.18
+	Sc
		887667 ACT_YEAST (730-877): 3.32e-52: 188: 15.66		RUVB1_YEAST (8-448): 0: 624: 41.10
+	Hs
		897003 ARP2_HUMAN (405-619): 8.71e-18: 88.7: 21.88		RUVB1_HUMAN (10-448): 0: 658: 41.72
+	Sc
		689377 ARP2_YEAST (405-619): 7.21e-15: 79.4: 18.75		RUVB1_YEAST (8-448): 0: 624: 41.10