HitPredict

Interactor 1: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Interactor 2: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	15456759, 34144977, 14576432, 17925232, 17500065
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045830 - positive regulation of isotype switching
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1972 Hs			1 1069
+	Mm
		936734 TP53B_MOUSE (1-1972): 0: 748: 79.85		PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47
+	Hs
		1018956 TP53B_HUMAN (1-1972): 0: 766: 100.00		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Mm
		936732 TP53B_MOUSE (1-1972): 0: 748: 79.85		MDC1_MOUSE (171-1069): 3.82e-52: 202: 14.92
+	Hs
		1019043 TP53B_HUMAN (1-1972): 0: 766: 100.00		TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86
+	Hs
		1056872 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00
+	Hs
		1173280 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00
+	Hs
		1056827 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		1056991 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		1056876 MICA3_HUMAN (254-923): 1.94e-14: 81.7: 14.49		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		1333815 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		1186092 MICA3_HUMAN (254-923): 1.94e-14: 81.7: 14.49		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		807652 MAP1B_HUMAN (50-1591): 3.52e-51: 202: 9.41		SC24C_HUMAN (182-460): 3.09e-12: 73.2: 8.84
+	Hs
		1056907 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86
+	Mm
		1351630 PCLO_MOUSE (2-1361): 6.91e-09: 63.7: 8.66		PCLO_MOUSE (190-871): 4.97e-25: 115: 10.12
+	Dm
		113976 M9PB30_DROME (1064-1755): 2.27e-09: 65.1: 8.65		M9PB30_DROME (150-909): 5.13e-11: 69.7: 8.92