Protein: LUZP1
Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin)

Gene: LUZP1
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q86V48

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0001725 - stress fiber
GO:0003281 - ventricular septum development
GO:0003383 - apical constriction
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

730014

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

212671

DAPK3
Death-associated protein kinase 3

3

10

High-throughput

0.671

High

966555

1433G
14-3-3 protein gamma

3

20

High-throughput

0.667

High

1049505

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

1147783

DHC24
Delta(24)-sterol reductase

3

2

High-throughput

0.667

High

1289972

KLDC3
Kelch domain-containing protein 3

3

15

High-throughput

0.662

High

1289988

ANLN
Anillin

3

12

High-throughput

0.656

High

1143387

PCM1
Pericentriolar material 1 protein

3

4

High-throughput

0.643

High

1289976

AASD1
Alanyl-tRNA editing protein Aarsd1

2

2

High-throughput

0.628

High

1289998

SCOC
Short coiled-coil protein

2

1

High-throughput

0.628

High

1152134

MARE1
Microtubule-associated protein RP/EB family member 1

2

7

High-throughput

0.611

High

1289964

BORC6
BLOC-1-related complex subunit 6

3

1

High-throughput

0.609

High

347148

BAG2
BAG family molecular chaperone regulator 2

2

1

High-throughput

0.601

High

1289967

SCLT1
Sodium channel and clathrin linker 1

2

20

High-throughput

0.588

High

1123698

DCTN1
Dynactin subunit 1

2

18

High-throughput

0.584

High

1226152

CP135
Centrosomal protein of 135 kDa

2

19

High-throughput

0.584

High

1289947

NIN
Ninein

2

20

High-throughput

0.584

High

1290003

CC14A
Dual specificity protein phosphatase CDC14A

2

17

High-throughput

0.584

High

1290006

NINL
Ninein-like protein

2

20

High-throughput

0.584

High

396435

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1289973

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.549

High

415686

HSPB1
Heat shock protein beta-1

1

10

High-throughput

0.541

High

302069

SEGN
Secretagogin

1

5

High-throughput

0.536

High

570481

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.536

High

630310

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

7

High-throughput

0.536

High

637609

FLNA
Filamin-A

1

20

High-throughput

0.536

High

659523

CRCM
Colorectal mutant cancer protein

1

19

High-throughput

0.536

High

667921

CDK2
Cyclin-dependent kinase 2

1

18

High-throughput

0.536

High

772888

MYH9
Myosin-9

1

18

High-throughput

0.536

High

862890

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

13

High-throughput

0.536

High

866749

CAZA2
F-actin-capping protein subunit alpha-2

1

11

High-throughput

0.536

High

913531

KIF11
Kinesin-like protein KIF11

1

8

High-throughput

0.536

High

958303

ARP2
Actin-related protein 2

1

20

High-throughput

0.536

High

968361

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

20

High-throughput

0.536

High

1052057

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1099719

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

1124640

SRC8
Src substrate cortactin

1

20

High-throughput

0.536

High

1160677

DREB
Drebrin

1

20

High-throughput

0.536

High

1289944

SYNPO
Synaptopodin

1

17

High-throughput

0.536

High

1289956

MY18A
Unconventional myosin-XVIIIa

1

19

High-throughput

0.536

High

1289965

MYO19
Unconventional myosin-XIX

1

19

High-throughput

0.536

High

1289978

DUS16
Dual specificity protein phosphatase 16

1

14

High-throughput

0.536

High

1289989

MYO5C
Unconventional myosin-Vc

1

20

High-throughput

0.536

High

1289990

PDLI7
PDZ and LIM domain protein 7

1

17

High-throughput

0.536

High

1289991

DISC1
Disrupted in schizophrenia 1 protein

1

8

High-throughput

0.536

High

1289997

LIMA1
LIM domain and actin-binding protein 1

1

14

High-throughput

0.536

High

372459

MYC
Myc proto-oncogene protein

2

15

High-throughput

0.533

High

323886

SC31A
Protein transport protein Sec31A

1

17

High-throughput

0.515

High

730730

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

971725

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.515

High

1228541

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.513

High

1289941

SYCE1
Synaptonemal complex central element protein 1

1

3

High-throughput

0.489

High

1289959

CUL5
Cullin-5

1

20

High-throughput

0.489

High

122801

KIF2A
Kinesin-like protein KIF2A

1

9

High-throughput

0.479

High

129229

MEN1
Menin

1

3

High-throughput

0.479

High

157568

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

163993

NDC80
Kinetochore protein NDC80 homolog

1

18

High-throughput

0.479

High

177011

CE290
Centrosomal protein of 290 kDa

1

20

High-throughput

0.479

High

223159

PRC1
Protein regulator of cytokinesis 1

1

18

High-throughput

0.479

High

247371

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

12

High-throughput

0.479

High

247984

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

290063

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

324166

CE152
Centrosomal protein of 152 kDa

1

19

High-throughput

0.479

High

331106

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

341611

EYA4
Protein phosphatase EYA4

1

9

High-throughput

0.479

High

346020

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

401080

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.479

High

425557

ISG15
Ubiquitin-like protein ISG15

1

16

High-throughput

0.479

High

464999

SP1
Transcription factor Sp1

1

12

Small-scale

0.479

High

474793

VIME
Vimentin

1

20

High-throughput

0.479

High

475618

K1C19
Keratin, type I cytoskeletal 19

1

17

High-throughput

0.479

High

535253

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

537444

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

556189

CADH1
Cadherin-1

1

10

High-throughput

0.479

High

582859

EZRI
Ezrin

1

20

High-throughput

0.479

High

606890

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

629939

BTF3
Transcription factor BTF3

1

11

High-throughput

0.479

High

691194

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

714237

PML
Protein PML

1

17

High-throughput

0.479

High

799259

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.479

High

831001

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

862269

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

867254

CAPZB
F-actin-capping protein subunit beta

1

7

High-throughput

0.479

High

872488

SOX2
Transcription factor SOX-2

1

12

High-throughput

0.479

High

891226

GSK3A
Glycogen synthase kinase-3 alpha

1

20

High-throughput

0.479

High

891655

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.479

High

900014

FXR1
RNA-binding protein FXR1

1

14

High-throughput

0.479

High

900397

FXR2
RNA-binding protein FXR2

1

14

High-throughput

0.479

High

951734

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

10

Small-scale

0.479

High

952932

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.479

High

982230

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

High-throughput

0.479

High

990436

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

991873

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.479

High

995673

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.479

High

1045464

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1056829

FMR1
Fragile X messenger ribonucleoprotein 1

1

14

High-throughput

0.479

High

1065727

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

20

High-throughput

0.479

High

1085585

FOXO1
Forkhead box protein O1

1

6

High-throughput

0.479

High

1087667

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

20

High-throughput

0.479

High

1100871

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.479

High

1107876

SQSTM
Sequestosome-1

1

11

High-throughput

0.479

High

1109857

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1115783

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.479

High

1118081

DX39B
Spliceosome RNA helicase DDX39B

1

14

High-throughput

0.479

High

1140498

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

1143181

PLEC
Plectin

1

20

High-throughput

0.479

High

1151351

TRIP4
Activating signal cointegrator 1

1

3

High-throughput

0.479

High

1156134

ZYX
Zyxin

1

8

High-throughput

0.479

High

1191437

GRDN
Girdin

1

17

High-throughput

0.479

High

1203180

ODFP2
Outer dense fiber protein 2

1

19

High-throughput

0.479

High

1210895

CE170
Centrosomal protein of 170 kDa

1

20

High-throughput

0.479

High

1215466

CE162
Centrosomal protein of 162 kDa

1

19

High-throughput

0.479

High

1228428

FTM
Protein fantom

1

20

High-throughput

0.479

High

1253224

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

20

High-throughput

0.479

High

1254464

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1256500

CE128
Centrosomal protein of 128 kDa

1

19

High-throughput

0.479

High

1271946

TEDC2
Tubulin epsilon and delta complex protein 2

1

3

High-throughput

0.479

High

1280870

CNTRL
Centriolin

1

19

High-throughput

0.479

High

1289937

LCA5
Lebercilin

1

19

High-throughput

0.479

High

1289938

HOOK3
Protein Hook homolog 3

1

20

High-throughput

0.479

High

1289939

MIB1
E3 ubiquitin-protein ligase MIB1

1

8

High-throughput

0.479

High

1289940

SMC5
Structural maintenance of chromosomes protein 5

1

20

High-throughput

0.479

High

1289942

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.479

High

1289943

CNTRB
Centrobin

1

20

High-throughput

0.479

High

1289945

FBXW8
F-box/WD repeat-containing protein 8

1

20

High-throughput

0.479

High

1289946

RYBP
RING1 and YY1-binding protein

1

7

High-throughput

0.479

High

1289949

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

1289950

CE120
Centrosomal protein of 120 kDa

1

20

High-throughput

0.479

High

1289951

POC1A
POC1 centriolar protein homolog A

1

20

High-throughput

0.479

High

1289952

BICD2
Protein bicaudal D homolog 2

1

18

High-throughput

0.479

High

1289953

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1289955

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

13

High-throughput

0.479

High

1289960

FBXW7
F-box/WD repeat-containing protein 7

1

19

High-throughput

0.479

High

1289962

CHM4C
Charged multivesicular body protein 4c

1

14

High-throughput

0.479

High

1289963

BICD1
Protein bicaudal D homolog 1

1

20

High-throughput

0.479

High

1289966

CEP63
Centrosomal protein of 63 kDa

1

18

High-throughput

0.479

High

1289968

SRPK1
SRSF protein kinase 1

1

17

High-throughput

0.479

High

1289969

CEP89
Centrosomal protein of 89 kDa

1

19

High-throughput

0.479

High

1289977

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

12

High-throughput

0.479

High

1289979

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1289980

TOLIP
Toll-interacting protein

1

2

High-throughput

0.479

High

1289982

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

1289983

CHM4B
Charged multivesicular body protein 4b

1

14

High-throughput

0.479

High

1289984

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1289985

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

1289986

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.479

High

1289987

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

1289995

ZO2
Tight junction protein 2

1

10

High-throughput

0.479

High

1289996

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1290000

BAG5
BAG family molecular chaperone regulator 5

1

4

High-throughput

0.479

High

1290002

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

16

High-throughput

0.479

High

1290004

MARE3
Microtubule-associated protein RP/EB family member 3

1

7

High-throughput

0.479

High

245334

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.458

High

1177957

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1289970

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1289994

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

1290005

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

62553

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.445

High

369188

OAS1
2'-5'-oligoadenylate synthase 1

1

3

High-throughput

0.445

High

516550

CALM3
Calmodulin-3

1

4

High-throughput

0.445

High

930971

HSP72
Heat shock-related 70 kDa protein 2

1

13

High-throughput

0.445

High

987746

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.445

High

1148304

CNN3
Calponin-3

1

17

High-throughput

0.445

High

1199564

KLH22
Kelch-like protein 22

1

8

High-throughput

0.445

High

1234846

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1289993

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

5

High-throughput

0.445

High

213622

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

3

High-throughput

0.437

High

246722

KDM1A
Lysine-specific histone demethylase 1A

1

10

High-throughput

0.437

High

283501

TAD2A
Transcriptional adapter 2-alpha

1

6

High-throughput

0.437

High

338505

SC24B
Protein transport protein Sec24B

1

3

High-throughput

0.437

High

589064

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

657622

GCSP
Glycine dehydrogenase

1

5

High-throughput

0.437

High

695853

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

768563

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

855465

ATRX
Transcriptional regulator ATRX

1

20

High-throughput

0.437

High

1137824

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

1155513

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.437

High

1156536

CCDC6
Coiled-coil domain-containing protein 6

1

19

High-throughput

0.437

High

1178772

AAK1
AP2-associated protein kinase 1

1

19

High-throughput

0.437

High

1276430

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1289954

BBX
HMG box transcription factor BBX

1

10

High-throughput

0.437

High

1289957

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1289958

TF3B
Transcription factor IIIB 90 kDa subunit

1

4

Small-scale

0.437

High

1289961

PF21A
PHD finger protein 21A

1

20

High-throughput

0.437

High

1289981

RNF38
E3 ubiquitin-protein ligase RNF38

1

9

Small-scale

0.437

High

1289999

RCOR1
REST corepressor 1

1

11

High-throughput

0.437

High

1290007

NGN3
Neurogenin-3

1

3

Small-scale

0.437

High

340645

STABP
STAM-binding protein

1

0

High-throughput

0.426

High

765672

BMI1
Polycomb complex protein BMI-1

1

18

High-throughput

0.407

High

1103258

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.407

High

1258484

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.407

High

1289971

ZBT18
Zinc finger and BTB domain-containing protein 18

1

9

High-throughput

0.407

High

1289975

WDR83
WD repeat domain-containing protein 83

1

20

High-throughput

0.407

High

1289992

VSX1
Visual system homeobox 1

1

4

High-throughput

0.407

High

1290001

PNMA2
Paraneoplastic antigen Ma2

1

8

High-throughput

0.407

High

1289948

CARME
Carnosine N-methyltransferase

3

0

High-throughput

0.347

High

1289974

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025