HitPredict

Interactor 1: DLG1 (Q12959)
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)
Gene: DLG1

Interactor 2: GRIK2 (Q13002)
Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
Gene: GRIK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11279111, 9808460
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0043113 - receptor clustering GO:0098839 - postsynaptic density membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 908
+	Hs
		1022366 DLG3_HUMAN (139-904): 0: 585: 66.28		GRIK2_HUMAN (1-908): 0: 965: 100.00
+	Hs
		786696 DLG1_HUMAN (1-904): 0: 725: 100.00		GRIA1_HUMAN (15-854): 0: 763: 39.46
+	Rn
		585151 DLG1_RAT (1-904): 0: 701: 92.54		GRIA1_RAT (14-854): 0: 759: 39.54
+	Mm
		620881 DLG3_MOUSE (99-904): 0: 589: 64.69		GRIA1_MOUSE (14-854): 0: 756: 39.54
+	Mm
		1142965 DLG1_MOUSE (1-904): 0: 720: 95.47		GRID2_MOUSE (12-907): 0: 608: 26.65
+	Hs
		984257 DLG1_HUMAN (1-904): 0: 725: 100.00		NMDZ1_HUMAN (11-906): 0: 603: 23.20
+	Mm
		723600 DLG1_MOUSE (1-904): 0: 720: 95.47		NMDZ1_MOUSE (11-906): 0: 601: 22.88
+	Rn
		1144011 DLG1_RAT (1-904): 0: 701: 92.54		GRID2_RAT (12-907): 0: 609: 26.55
+	Hs
		1081918 DLG3_HUMAN (139-904): 0: 585: 66.28		GRIK5_HUMAN (20-902): 0: 704: 43.83
+	Rn
		723628 DLG3_RAT (99-904): 0: 590: 64.57		NMDZ1_RAT (11-906): 0: 602: 22.99
+	Mm
		723568 DLG3_MOUSE (99-904): 0: 589: 64.69		NMDZ1_MOUSE (11-906): 0: 601: 22.88
+	Hs
		942335 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		GRIK2_HUMAN (1-908): 0: 965: 100.00
+	Rn
		677766 DLG4_RAT (86-493): 2.93e-24: 111: 15.40		GRIK2_RAT (1-908): 0: 961: 99.12
+	Hs
		761199 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		GRIK1_HUMAN (14-854): 0: 874: 80.26
+	Hs
		786757 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		GRIA3_HUMAN (8-863): 0: 764: 39.02
+	Rn
		585138 DLG4_RAT (86-493): 2.93e-24: 111: 15.40		GRIA1_RAT (14-854): 0: 759: 39.54
+	Hs
		786726 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		GRIA2_HUMAN (13-863): 0: 746: 38.33
+	Hs
		942350 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		GRIK5_HUMAN (20-902): 0: 704: 43.83
+	Hs
		942329 DLG4_HUMAN (86-493): 2.62e-24: 111: 15.64		NMDZ1_HUMAN (11-906): 0: 603: 23.20
+	Rn
		677765 DLG4_RAT (86-493): 2.93e-24: 111: 15.40		NMDZ1_RAT (11-906): 0: 602: 22.99