Protein: BCR
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)

Gene: BCR
Organism: Homo sapiens
Interactions: 222
UniProt ID: P11274

Gene Ontology (top 5):
GO:0002692 - negative regulation of cellular extravasation
GO:0003014 - renal system process
GO:0004674 - protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005085 - guanyl-nucleotide exchange factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539994

GRB2
Growth factor receptor-bound protein 2

15

20

Small-scale

0.987

High

362139

ABL1
Tyrosine-protein kinase ABL1

4

19

Small-scale

0.899

High

539970

CRKL
Crk-like protein

3

20

Small-scale

0.864

High

456088

FES
Tyrosine-protein kinase Fes/Fps

2

20

Small-scale

0.806

High

539948

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

18

Small-scale

0.768

High

539969

CRK
Adapter molecule crk

2

20

Small-scale

0.768

High

539989

RHOA
Transforming protein RhoA

2

20

Small-scale

0.768

High

539995

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.768

High

540049

ARG39
Rho guanine nucleotide exchange factor 39

2

18

High-throughput

0.767

High

473357

HCK
Tyrosine-protein kinase HCK

2

19

Small-scale

0.754

High

539949

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

11

Small-scale

0.754

High

539993

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

540004

SOS1
Son of sevenless homolog 1

2

15

Small-scale

0.754

High

540069

AP2M1
AP-2 complex subunit mu

7

9

High-throughput

0.745

High

540078

DOK1
Docking protein 1

1

3

Small-scale

0.724

High

539941

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

5

2

Small-scale

0.724

High

539942

CSK22
Casein kinase II subunit alpha'

5

9

High-throughput

0.722

High

540002

1433F
14-3-3 protein eta

4

20

High-throughput

0.694

High

292805

GRAP2
GRB2-related adapter protein 2

1

20

High-throughput

0.691

High

539966

FRK
Tyrosine-protein kinase FRK

1

19

High-throughput

0.691

High

540089

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.691

High

539953

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

540000

CSK21
Casein kinase II subunit alpha

4

12

High-throughput

0.691

High

539990

1433G
14-3-3 protein gamma

4

20

High-throughput

0.687

High

539943

CBL
E3 ubiquitin-protein ligase CBL

4

18

Small-scale

0.686

High

539983

AFAD
Afadin

3

20

Small-scale

0.674

High

279268

TULP3
Tubby-related protein 3

3

3

High-throughput

0.667

High

539984

SEC13
Protein SEC13 homolog

3

10

High-throughput

0.667

High

539991

1433E
14-3-3 protein epsilon

3

14

High-throughput

0.667

High

540032

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

3

20

Small-scale

0.662

High

539938

EZRI
Ezrin

3

14

High-throughput

0.656

High

539985

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.647

High

539940

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

11

Small-scale

0.646

High

461076

HS90A
Heat shock protein HSP 90-alpha

3

8

Small-scale

0.640

High

540012

SQSTM
Sequestosome-1

3

11

Small-scale

0.640

High

539997

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

540073

JPH4
Junctophilin-4

2

3

High-throughput

0.628

High

136273

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

168032

RGS12
Regulator of G-protein signaling 12

1

1

Small-scale

0.618

High

187269

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

7

High-throughput

0.618

High

375125

RASK
GTPase KRas

1

20

High-throughput

0.618

High

466085

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

539950

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.618

High

539957

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.618

High

539986

RAB2A
Ras-related protein Rab-2A

1

11

High-throughput

0.618

High

539988

ACTZ
Alpha-centractin

1

18

High-throughput

0.618

High

539992

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.618

High

540063

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

9

Small-scale

0.618

High

540088

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

540093

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

10

Small-scale

0.618

High

540099

ZO2
Tight junction protein 2

1

18

Small-scale

0.618

High

540110

GAB2
GRB2-associated-binding protein 2

1

17

Small-scale

0.618

High

413076

P53
Cellular tumor antigen p53

2

6

High-throughput

0.614

High

371024

MYC
Myc proto-oncogene protein

2

8

Small-scale

0.611

High

539959

RADI
Radixin

2

13

High-throughput

0.611

High

539999

CSK2B
Casein kinase II subunit beta

2

4

High-throughput

0.611

High

540005

DDR1
Epithelial discoidin domain-containing receptor 1

2

20

High-throughput

0.611

High

540041

SH2D5
SH2 domain-containing protein 5

2

3

Small-scale

0.611

High

540034

CC183
Coiled-coil domain-containing protein 183

3

12

High-throughput

0.609

High

540051

COMD1
COMM domain-containing protein 1

2

0

High-throughput

0.602

High

540101

NAGK
N-acetyl-D-glucosamine kinase

2

0

High-throughput

0.602

High

540086

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

12

Small-scale

0.586

High

540072

IGS21
Immunoglobulin superfamily member 21

1

0

High-throughput

0.584

High

540075

ERBIN
Erbin

1

8

Small-scale

0.578

High

540015

GRAP
GRB2-related adapter protein

1

20

Small-scale

0.575

High

540079

TS101
Tumor susceptibility gene 101 protein

1

1

Small-scale

0.573

High

344612

AP2A1
AP-2 complex subunit alpha-1

2

18

High-throughput

0.571

High

536377

HSP7C
Heat shock cognate 71 kDa protein

1

5

Small-scale

0.561

High

540039

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

507467

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.552

High

540011

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.541

High

137933

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.536

High

174910

SC16A
Protein transport protein Sec16A

1

6

High-throughput

0.536

High

539936

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

539946

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

539954

IL3RB
Cytokine receptor common subunit beta

1

4

Small-scale

0.536

High

539961

NU214
Nuclear pore complex protein Nup214

1

12

High-throughput

0.536

High

539964

NAA10
N-alpha-acetyltransferase 10

1

2

High-throughput

0.536

High

539967

RAGP1
Ran GTPase-activating protein 1

1

3

High-throughput

0.536

High

539971

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.536

High

539972

UTRN
Utrophin

1

20

High-throughput

0.536

High

539998

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

540001

TFAM
Transcription factor A, mitochondrial

1

9

High-throughput

0.536

High

540009

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.536

High

540016

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

4

High-throughput

0.536

High

540021

DPYL2
Dihydropyrimidinase-related protein 2

1

5

High-throughput

0.536

High

540022

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

11

High-throughput

0.536

High

540027

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

6

High-throughput

0.536

High

540029

RRP12
RRP12-like protein

1

1

High-throughput

0.536

High

540031

NU188
Nucleoporin NUP188

1

1

High-throughput

0.536

High

540036

EDC4
Enhancer of mRNA-decapping protein 4

1

12

High-throughput

0.536

High

540047

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

540053

PSD4
PH and SEC7 domain-containing protein 4

1

7

High-throughput

0.536

High

540054

WDR48
WD repeat-containing protein 48

1

12

High-throughput

0.536

High

540056

DDX54
ATP-dependent RNA helicase DDX54

1

3

High-throughput

0.536

High

540060

GCN1
Stalled ribosome sensor GCN1

1

12

High-throughput

0.536

High

540066

ARRD3
Arrestin domain-containing protein 3

1

5

High-throughput

0.536

High

540068

P5CR2
Pyrroline-5-carboxylate reductase 2

1

3

High-throughput

0.536

High

540082

GTPB4
GTP-binding protein 4

1

1

High-throughput

0.536

High

540091

SYNCI
Syncoilin

1

16

High-throughput

0.536

High

540098

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

3

High-throughput

0.536

High

540100

DDX20
Probable ATP-dependent RNA helicase DDX20

1

8

High-throughput

0.536

High

540107

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.536

High

540115

BACE2
Beta-secretase 2

1

2

High-throughput

0.536

High

355060

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

20

Small-scale

0.534

High

63946

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.513

High

539937

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

539952

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

539973

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.513

High

539987

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.513

High

540010

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.513

High

540033

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.513

High

540059

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

540070

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.513

High

540071

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.513

High

540083

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.513

High

540095

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

540097

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.513

High

540108

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.501

High

540024

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.500

High

290433

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.489

High

540025

INF2
Inverted formin-2

1

8

High-throughput

0.489

High

540028

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

10

High-throughput

0.489

High

540105

PNMA2
Paraneoplastic antigen Ma2

1

5

High-throughput

0.489

High

540114

TF3C3
General transcription factor 3C polypeptide 3

1

6

High-throughput

0.489

High

540003

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.480

High

160043

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

2

High-throughput

0.479

High

160160

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

2

High-throughput

0.479

High

172435

XPO1
Exportin-1

1

16

High-throughput

0.479

High

243884

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

13

High-throughput

0.479

High

246410

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

315055

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

317129

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

2

Small-scale

0.479

High

327762

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.479

High

331956

KAT7
Histone acetyltransferase KAT7

1

2

High-throughput

0.479

High

345301

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

411258

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

442557

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

459421

PROF1
Profilin-1

1

7

High-throughput

0.479

High

483000

CLCA
Clathrin light chain A

1

7

High-throughput

0.479

High

532035

KIT
Mast/stem cell growth factor receptor Kit

1

13

Small-scale

0.479

High

532314

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.479

High

539945

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

14

High-throughput

0.479

High

539951

WEE1
Wee1-like protein kinase

1

13

High-throughput

0.479

High

539955

MCM4
DNA replication licensing factor MCM4

1

8

High-throughput

0.479

High

539956

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

539958

CTNA1
Catenin alpha-1

1

9

High-throughput

0.479

High

539963

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

539965

EPS15
Epidermal growth factor receptor substrate 15

1

20

High-throughput

0.479

High

539968

ATRX
Transcriptional regulator ATRX

1

2

High-throughput

0.479

High

539974

KC1A
Casein kinase I isoform alpha

1

9

High-throughput

0.479

High

539975

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

6

Small-scale

0.479

High

539976

PAXI
Paxillin

1

13

Small-scale

0.479

High

539978

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

539979

GSK3A
Glycogen synthase kinase-3 alpha

1

7

High-throughput

0.479

High

539980

GSK3B
Glycogen synthase kinase-3 beta

1

7

High-throughput

0.479

High

539981

VASP
Vasodilator-stimulated phosphoprotein

1

10

High-throughput

0.479

High

539982

PLK1
Serine/threonine-protein kinase PLK1

1

16

High-throughput

0.479

High

539996

AP2B1
AP-2 complex subunit beta

1

20

High-throughput

0.479

High

540006

RBBP4
Histone-binding protein RBBP4

1

7

High-throughput

0.479

High

540007

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.479

High

540008

ANK3
Ankyrin-3

1

12

High-throughput

0.479

High

540013

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

540014

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

540017

MCM6
DNA replication licensing factor MCM6

1

8

High-throughput

0.479

High

540018

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

6

High-throughput

0.479

High

540019

TEBP
Prostaglandin E synthase 3

1

2

Small-scale

0.479

High

540020

CCDC6
Coiled-coil domain-containing protein 6

1

20

High-throughput

0.479

High

540023

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.479

High

540026

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

540035

CP135
Centrosomal protein of 135 kDa

1

11

High-throughput

0.479

High

540058

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

540061

ESR2
Estrogen receptor beta

1

17

High-throughput

0.479

High

540062

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

540064

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

14

High-throughput

0.479

High

540076

CCNL2
Cyclin-L2

1

3

High-throughput

0.479

High

540084

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.479

High

540087

PININ
Pinin

1

4

High-throughput

0.479

High

540090

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

540102

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

High-throughput

0.479

High

540106

BRPF3
Bromodomain and PHD finger-containing protein 3

1

3

High-throughput

0.479

High

540111

NINL
Ninein-like protein

1

20

High-throughput

0.479

High

540112

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

540113

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

4

High-throughput

0.479

High

167561

GIPC1
PDZ domain-containing protein GIPC1

1

0

Small-scale

0.458

High

539944

GBRR1
Gamma-aminobutyric acid receptor subunit rho-1

1

0

Small-scale

0.458

High

540030

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

540038

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.458

High

540045

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.458

High

540050

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.458

High

540103

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.458

High

410558

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.445

High

540074

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.445

High

540055

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.439

High

174480

TRI66
Tripartite motif-containing protein 66

1

9

High-throughput

0.437

High

539939

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

539947

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

539960

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

539962

TCF7
Transcription factor 7

1

3

Small-scale

0.437

High

540037

WDR82
WD repeat-containing protein 82

1

20

High-throughput

0.437

High

540040

CE128
Centrosomal protein of 128 kDa

1

20

High-throughput

0.437

High

540044

PCGF5
Polycomb group RING finger protein 5

1

5

High-throughput

0.437

High

540046

HOOK3
Protein Hook homolog 3

1

20

High-throughput

0.437

High

540052

SCAI
Protein SCAI

1

1

Small-scale

0.437

High

540057

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.437

High

540065

VP33A
Vacuolar protein sorting-associated protein 33A

1

3

High-throughput

0.437

High

540067

PF21A
PHD finger protein 21A

1

2

High-throughput

0.437

High

540081

CECR2
Chromatin remodeling regulator CECR2

1

8

High-throughput

0.437

High

540094

SP110
Sp110 nuclear body protein

1

4

High-throughput

0.437

High

540104

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

540109

MARE3
Microtubule-associated protein RP/EB family member 3

1

7

High-throughput

0.437

High

71051

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

540085

RSPH9
Radial spoke head protein 9 homolog

3

0

High-throughput

0.347

High

539977

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.279

Low

540042

TRM1L
tRNA

1

0

High-throughput

0.279

Low

540043

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.279

Low

540048

RM41
Large ribosomal subunit protein mL41

1

0

High-throughput

0.279

Low

540077

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.279

Low

475234

IL3
Interleukin-3

1

0

Small-scale

0.249

Low

540080

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.249

Low

540092

NRDE2
Nuclear exosome regulator NRDE2

1

0

High-throughput

0.249

Low

540096

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025