Protein: DOK1
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)

Gene: DOK1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q99704

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635746

RASA1
Ras GTPase-activating protein 1

9

20

Small-scale

0.966

High

362358

ABL1
Tyrosine-protein kinase ABL1

6

20

Small-scale

0.949

High

855926

CRKL
Crk-like protein

5

20

Small-scale

0.928

High

222185

NCK2
Cytoplasmic protein NCK2

5

20

Small-scale

0.922

High

363765

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.858

High

840894

TEC
Tyrosine-protein kinase Tec

2

20

Small-scale

0.825

High

463726

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.799

High

1272293

DOK3
Docking protein 3

2

11

High-throughput

0.767

High

464042

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.740

High

486706

FGR
Tyrosine-protein kinase Fgr

2

20

Small-scale

0.738

High

557444

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.738

High

1406539

SRMS
Tyrosine-protein kinase Srms

1

20

Small-scale

0.730

High

594088

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.727

High

532100

KIT
Mast/stem cell growth factor receptor Kit

1

10

Small-scale

0.724

High

540078

BCR
Breakpoint cluster region protein

1

3

Small-scale

0.724

High

167960

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.691

High

909153

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.691

High

683627

ITB7
Integrin beta-7

2

4

Small-scale

0.687

High

411019

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

424041

ITB3
Integrin beta-3

1

4

Small-scale

0.647

High

431886

ITB1
Integrin beta-1

1

4

Small-scale

0.647

High

463208

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.647

High

473465

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.647

High

619097

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

4

Small-scale

0.647

High

1406540

TLN1
Talin-1

1

4

Small-scale

0.647

High

1369277

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

3

7

Small-scale

0.646

High

249773

DOK2
Docking protein 2

1

13

Small-scale

0.618

High

987891

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

1227334

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.618

High

1406536

DOK1
Docking protein 1

1

11

Small-scale

0.618

High

258612

SH21A
SH2 domain-containing protein 1A

1

20

Small-scale

0.586

High

439838

INSR
Insulin receptor

1

20

Small-scale

0.579

High

699839

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

18

Small-scale

0.571

High

711402

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.563

High

424098

ITB2
Integrin beta-2

1

4

Small-scale

0.553

High

584579

VAV
Proto-oncogene vav

1

15

Small-scale

0.527

High

840979

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.527

High

855740

CRK
Adapter molecule crk

1

20

Small-scale

0.527

High

1065091

ITK
Tyrosine-protein kinase ITK/TSK

1

20

Small-scale

0.527

High

1118419

PTK6
Protein-tyrosine kinase 6

1

20

Small-scale

0.527

High

1260295

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

Small-scale

0.479

High

532176

CD28
T-cell-specific surface glycoprotein CD28

1

0

Small-scale

0.458

High

1252950

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

952304

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

1053732

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

15

Small-scale

0.445

High

1406537

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.445

High

1406538

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

1316969

FAM9B
Protein FAM9B

1

0

High-throughput

0.426

High

1315198

GT252
Procollagen galactosyltransferase 2

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025