HitPredict

Interactor 1: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	25900982, 28514442, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 487 Hs			1 605
+	Hs
		1027457 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1023136 STK4_HUMAN (1-487): 7.89e-170: 489: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		568836 KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1027451 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		568826 KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1027412 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Dm
		1213409 AKT1_DROME (1-344): 1.74e-134: 403: 22.32		NLE_DROME (218-531): 8.76e-63: 216: 20.22
+	Dm
		218248 AKT1_DROME (1-344): 1.74e-134: 403: 22.32		O44382_DROME (466-605): 2.38e-30: 127: 29.37
+	Dm
		1213390 AKT1_DROME (1-344): 1.74e-134: 403: 22.32		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	Hs
		1272883 M4K1_HUMAN (17-281): 2.36e-74: 252: 45.22		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		793038 TNIK_HUMAN (8-309): 2.1e-73: 254: 44.80		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Dm
		1363651 PAK_DROME (3-301): 3.9e-117: 361: 39.81		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	Hs
		1163009 M4K3_HUMAN (20-344): 2.76e-114: 359: 42.47		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		197010 M4K2_HUMAN (17-316): 3.72e-75: 254: 42.67		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66
+	Hs
		1163057 M4K5_HUMAN (20-318): 7.15e-75: 253: 44.30		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Mm
		949357 TNIK_MOUSE (8-309): 1.1e-73: 254: 44.80		TBL1R_MOUSE (501-605): 5.38e-15: 80: 16.67
+	Dm
		1249851 HIPPO_DROME (430-486): 2.19e-11: 68.4: 54.39		FBXW7_DROME (414-604): 1.53e-53: 199: 30.73
+	Dm
		1249839 HIPPO_DROME (430-486): 2.19e-11: 68.4: 54.39		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37