HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 776
+	Hs
		1020647 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		1041301 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		1020648 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		1042922 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		1274093 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Mm
		936275 TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51		CUL5_MOUSE (2-776): 0: 615: 28.48
+	Hs
		129560 TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		1024672 TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		1042435 TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86		CUL3_HUMAN (9-776): 0: 748: 30.47