Protein: TRAF4
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)

Gene: TRAF4
Organism: Homo sapiens
Interactions: 207
UniProt ID: Q9BUZ4

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005164 - tumor necrosis factor receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

509725

UBL4A
Ubiquitin-like protein 4A

4

20

High-throughput

0.904

High

1237128

UBL4B
Ubiquitin-like protein 4B

4

16

High-throughput

0.901

High

1238399

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

1

High-throughput

0.861

High

1313380

UBQL2
Ubiquilin-2

3

15

High-throughput

0.843

High

537032

TRI27
Zinc finger protein RFP

2

19

High-throughput

0.783

High

849427

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.778

High

1313351

TRAF4
TNF receptor-associated factor 4

6

19

Small-scale

0.742

High

573064

PRS6A
26S proteasome regulatory subunit 6A

6

9

Small-scale

0.735

High

1313374

TBCD7
TBC1 domain family member 7

5

1

High-throughput

0.724

High

537668

NCF1
Neutrophil cytosol factor 1

5

5

Small-scale

0.714

High

1313360

SMUF2
E3 ubiquitin-protein ligase SMURF2

4

15

Small-scale

0.707

High

1238506

BANP
Protein BANP

4

4

High-throughput

0.705

High

1149320

K1C40
Keratin, type I cytoskeletal 40

4

20

High-throughput

0.704

High

125689

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

4

15

High-throughput

0.703

High

1046940

BYST
Bystin

4

4

High-throughput

0.703

High

1184790

ATOSB
Atos homolog protein B

4

1

High-throughput

0.688

High

1273839

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

12

Small-scale

0.680

High

1313361

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

3

15

High-throughput

0.678

High

563794

ZNF3
Zinc finger protein 3

3

20

High-throughput

0.675

High

814525

SYQ
Glutamine--tRNA ligase

3

2

High-throughput

0.675

High

1071366

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.675

High

1252693

BAHD1
Bromo adjacent homology domain-containing 1 protein

3

2

High-throughput

0.675

High

1313375

ZN581
Zinc finger protein 581

3

20

High-throughput

0.675

High

995190

GOGA2
Golgin subfamily A member 2

3

20

High-throughput

0.671

High

160173

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

6

High-throughput

0.667

High

842636

RL14
Large ribosomal subunit protein eL14

3

3

High-throughput

0.667

High

1186295

CTSR4
Cation channel sperm-associated protein 4

3

3

High-throughput

0.667

High

1183306

Q7KZS0
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.665

High

232473

KDM1A
Lysine-specific histone demethylase 1A

3

7

High-throughput

0.661

High

840809

DYN2
Dynamin-2

3

2

High-throughput

0.660

High

1252445

LNX1
E3 ubiquitin-protein ligase LNX

3

20

Small-scale

0.653

High

301996

TRI37
E3 ubiquitin-protein ligase TRIM37

1

18

Small-scale

0.647

High

476299

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

1313363

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

15

Small-scale

0.644

High

682006

AKT1
RAC-alpha serine/threonine-protein kinase

3

12

Small-scale

0.640

High

1020902

TRAF2
TNF receptor-associated factor 2

3

18

Small-scale

0.640

High

200185

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

2

17

Small-scale

0.639

High

1313392

TRAF6
TNF receptor-associated factor 6

2

19

Small-scale

0.634

High

1220201

HOMEZ
Homeobox and leucine zipper protein Homez

2

6

High-throughput

0.633

High

436641

TNR16
Tumor necrosis factor receptor superfamily member 16

2

20

Small-scale

0.629

High

1313367

INO1
Inositol-3-phosphate synthase 1

2

0

High-throughput

0.626

High

930374

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.621

High

1313354

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

20

Small-scale

0.618

High

1052836

FAK2
Protein-tyrosine kinase 2-beta

2

15

Small-scale

0.611

High

616728

KS6B1
Ribosomal protein S6 kinase beta-1

2

8

Small-scale

0.608

High

118604

EYA2
Eyes absent homolog 2

2

8

High-throughput

0.606

High

207368

FRS3
Fibroblast growth factor receptor substrate 3

2

2

High-throughput

0.606

High

280824

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.606

High

447285

HXB5
Homeobox protein Hox-B5

2

20

High-throughput

0.606

High

829992

HXA1
Homeobox protein Hox-A1

2

20

High-throughput

0.606

High

854461

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

2

High-throughput

0.606

High

941379

RNF4
E3 ubiquitin-protein ligase RNF4

2

18

High-throughput

0.606

High

966284

TFAP4
Transcription factor AP-4

2

1

High-throughput

0.606

High

984017

ZBT16
Zinc finger and BTB domain-containing protein 16

2

17

High-throughput

0.606

High

1032331

ZN177
Zinc finger protein 177

2

17

High-throughput

0.606

High

1073632

SF3B4
Splicing factor 3B subunit 4

2

7

High-throughput

0.606

High

1075448

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

12

High-throughput

0.606

High

1144764

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

15

High-throughput

0.606

High

1153361

PKHA7
Pleckstrin homology domain-containing family A member 7

2

20

High-throughput

0.606

High

1159081

CEP85
Centrosomal protein of 85 kDa

2

19

High-throughput

0.606

High

1169349

ZN620
Zinc finger protein 620

2

20

High-throughput

0.606

High

1201894

TAXB1
Tax1-binding protein 1

2

20

High-throughput

0.606

High

1230711

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

3

High-throughput

0.606

High

1241291

ZN784
Zinc finger protein 784

2

18

High-throughput

0.606

High

1271395

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

11

High-throughput

0.606

High

1299853

LENG8
Leukocyte receptor cluster member 8

2

5

High-throughput

0.606

High

1310071

TIRR
Tudor-interacting repair regulator protein

2

2

High-throughput

0.606

High

1312869

BEGIN
Brain-enriched guanylate kinase-associated protein

2

1

High-throughput

0.606

High

1313353

BACH2
Transcription regulator protein BACH2

2

20

High-throughput

0.606

High

1313355

ZC12C
Probable ribonuclease ZC3H12C

2

5

High-throughput

0.606

High

1313364

ZBT26
Zinc finger and BTB domain-containing protein 26

2

20

High-throughput

0.606

High

1313366

HM20A
High mobility group protein 20A

2

13

High-throughput

0.606

High

1313368

PICK1
PRKCA-binding protein

2

6

High-throughput

0.606

High

1313369

DISC1
Disrupted in schizophrenia 1 protein

2

3

High-throughput

0.606

High

1313371

ZN275
Zinc finger protein 275

2

17

High-throughput

0.606

High

1313376

ABI3
ABI gene family member 3

2

7

High-throughput

0.606

High

1313378

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

2

3

High-throughput

0.606

High

1313379

ZRAN1
Ubiquitin thioesterase ZRANB1

2

20

High-throughput

0.606

High

1313382

ZMYM5
Zinc finger MYM-type protein 5

2

3

High-throughput

0.606

High

1313384

PLAL2
Zinc finger protein PLAGL2

2

19

High-throughput

0.606

High

1313387

ZN835
Zinc finger protein 835

2

15

High-throughput

0.606

High

1313390

ARIP4
Helicase ARIP4

2

4

High-throughput

0.606

High

1023937

RM28
Large ribosomal subunit protein bL28m

2

0

High-throughput

0.601

High

1313372

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

2

0

High-throughput

0.601

High

153775

ANM5
Protein arginine N-methyltransferase 5

2

6

Small-scale

0.601

High

855722

KIF11
Kinesin-like protein KIF11

2

6

Small-scale

0.601

High

1313359

GORS2
Golgi reassembly-stacking protein 2

2

4

High-throughput

0.590

High

1313394

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

10

Small-scale

0.584

High

539133

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.580

High

1124839

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

1204019

EZHIP
EZH inhibitory protein

2

0

High-throughput

0.580

High

253600

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

10

High-throughput

0.573

High

669198

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

19

High-throughput

0.573

High

928183

SUMO1
Small ubiquitin-related modifier 1

1

10

High-throughput

0.573

High

1043742

ASPP2
Apoptosis-stimulating of p53 protein 2

1

20

High-throughput

0.573

High

1188185

KANL1
KAT8 regulatory NSL complex subunit 1

1

2

High-throughput

0.573

High

1289341

SPDLY
Protein Spindly

1

12

High-throughput

0.573

High

1313357

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

15

High-throughput

0.573

High

1224230

DOCK3
Dedicator of cytokinesis protein 3

2

2

High-throughput

0.571

High

1233853

ARG39
Rho guanine nucleotide exchange factor 39

2

5

High-throughput

0.571

High

385449

NTRK1
High affinity nerve growth factor receptor

1

14

Small-scale

0.561

High

526531

GP1BB
Platelet glycoprotein Ib beta chain

1

1

Small-scale

0.561

High

724564

IRS1
Insulin receptor substrate 1

1

5

Small-scale

0.561

High

975000

CAV1
Caveolin-1

1

4

Small-scale

0.561

High

154233

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.554

High

62413

GG6L9
Golgin subfamily A member 6-like protein 9

2

17

High-throughput

0.553

High

1110203

T10IP
Testis-specific protein 10-interacting protein

2

1

High-throughput

0.553

High

1309787

GORS1
Golgi reassembly-stacking protein 1

2

4

High-throughput

0.553

High

1313373

GOG6A
Golgin subfamily A member 6A

2

20

High-throughput

0.553

High

1313388

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.549

High

610499

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.541

High

1313383

CBLC
E3 ubiquitin-protein ligase CBL-C

1

9

High-throughput

0.541

High

1313393

RN114
E3 ubiquitin-protein ligase RNF114

1

18

High-throughput

0.541

High

1274221

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.536

High

280916

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.536

High

338927

EGFR
Epidermal growth factor receptor

1

14

Small-scale

0.536

High

1133757

BEND3
BEN domain-containing protein 3

1

2

High-throughput

0.536

High

1271752

TANK
TRAF family member-associated NF-kappa-B activator

1

10

High-throughput

0.536

High

1313370

SALL1
Sal-like protein 1

1

9

High-throughput

0.536

High

1313381

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.536

High

122328

ATOX1
Copper transport protein ATOX1

1

0

Small-scale

0.529

High

724993

MYH9
Myosin-9

1

9

Small-scale

0.515

High

796826

TNR4
Tumor necrosis factor receptor superfamily member 4

1

20

Small-scale

0.515

High

848465

IRAK1
Interleukin-1 receptor-associated kinase 1

1

11

Small-scale

0.515

High

989752

TNR9
Tumor necrosis factor receptor superfamily member 9

1

20

Small-scale

0.515

High

1216101

TCAM1
TIR domain-containing adapter molecule 1

1

11

Small-scale

0.515

High

57724

A2BDE7
PHLDA1 protein

1

2

High-throughput

0.515

High

607150

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

3

High-throughput

0.515

High

1199155

Q86U76
Zinc finger protein 3

1

19

High-throughput

0.515

High

1220121

GOR
Putative exonuclease GOR

1

2

High-throughput

0.515

High

1264477

ING5
Inhibitor of growth protein 5

1

0

High-throughput

0.513

High

1025532

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

Small-scale

0.508

High

1128900

GASP1
G-protein coupled receptor-associated sorting protein 1

1

1

Small-scale

0.508

High

1138310

MYOME
Myomegalin

1

16

Small-scale

0.508

High

1296235

Z512B
Zinc finger protein 512B

1

17

High-throughput

0.508

High

1306190

NPAS2
Neuronal PAS domain-containing protein 2

1

15

Small-scale

0.508

High

1299178

MIA2
Melanoma inhibitory activity protein 2

2

15

High-throughput

0.504

High

167608

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.501

High

175164

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

738694

TNR3
Tumor necrosis factor receptor superfamily member 3

1

20

Small-scale

0.501

High

152035

TOR1A
Torsin-1A

1

0

High-throughput

0.493

High

1230636

CARTF
Calcium-responsive transcription factor

1

0

High-throughput

0.493

High

365233

FRIH
Ferritin heavy chain

1

1

Small-scale

0.481

High

473710

ZN688
Zinc finger protein 688

1

20

High-throughput

0.481

High

969614

CENPE
Centromere-associated protein E

1

6

Small-scale

0.481

High

1189999

R144B
E3 ubiquitin-protein ligase RNF144B

1

12

High-throughput

0.481

High

1230265

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

18

High-throughput

0.481

High

1261015

PHLA1
Pleckstrin homology-like domain family A member 1

1

2

High-throughput

0.481

High

1297756

FXL18
F-box/LRR-repeat protein 18

1

1

High-throughput

0.481

High

1313377

MAGC2
Melanoma-associated antigen C2

1

7

Small-scale

0.481

High

1313385

EXOC7
Exocyst complex component 7

1

1

High-throughput

0.481

High

201418

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.479

High

201823

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.479

High

383961

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

13

Small-scale

0.479

High

456637

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

Small-scale

0.479

High

487734

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

489244

H14
Histone H1.4

1

9

Small-scale

0.479

High

538014

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

578103

RL17
Large ribosomal subunit protein uL22

1

4

Small-scale

0.479

High

587813

NCF2
Neutrophil cytosol factor 2

1

7

Small-scale

0.479

High

639638

TNR5
Tumor necrosis factor receptor superfamily member 5

1

20

Small-scale

0.479

High

642557

RL13
Large ribosomal subunit protein eL13

1

3

Small-scale

0.479

High

717316

CTNB1
Catenin beta-1

1

7

Small-scale

0.479

High

718156

BMI1
Polycomb complex protein BMI-1

1

18

High-throughput

0.479

High

738575

TGFR1
TGF-beta receptor type-1

1

6

Small-scale

0.479

High

740054

TGFR2
TGF-beta receptor type-2

1

7

Small-scale

0.479

High

883631

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

Small-scale

0.479

High

905723

RS7
Small ribosomal subunit protein eS7

1

1

Small-scale

0.479

High

916346

RL23A
Large ribosomal subunit protein uL23

1

2

Small-scale

0.479

High

922693

RL10A
Large ribosomal subunit protein uL1

1

3

Small-scale

0.479

High

935190

H31
Histone H3.1

1

5

Small-scale

0.479

High

971565

RL18A
Large ribosomal subunit protein eL20

1

3

Small-scale

0.479

High

1042435

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1058285

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

13

Small-scale

0.479

High

1063595

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1065711

SETB1
Histone-lysine N-methyltransferase SETDB1

1

6

Small-scale

0.479

High

1216697

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

18

Small-scale

0.479

High

1269502

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1305587

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.479

High

1313352

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

1

Small-scale

0.479

High

1313362

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

10

Small-scale

0.479

High

1313365

GPVI
Platelet glycoprotein VI

1

4

Small-scale

0.479

High

1313386

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

10

Small-scale

0.479

High

1313389

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

1313391

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

Small-scale

0.479

High

66771

A8KA13
B-cell CLL/lymphoma 6, member B

1

19

High-throughput

0.470

High

1287771

Q96D16
FBXL18 protein

1

1

High-throughput

0.470

High

1313358

RPB1C
DNA-directed RNA polymerase II subunit RPB11-b2

1

2

High-throughput

0.470

High

1205617

F90A1
Protein FAM90A1

1

1

High-throughput

0.464

High

1055011

FAT1
Protocadherin Fat 1

1

0

Small-scale

0.460

High

805782

RL27A
Large ribosomal subunit protein uL15

1

0

Small-scale

0.458

High

1284231

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

3339

A0A0S2Z5G4
Protein BANP

1

4

High-throughput

0.457

High

72493

B4DE54
Protein BANP

1

4

High-throughput

0.457

High

1313395

X5D7T2
Aryl-hydrocarbon receptor nuclear translocator 2 isoform C

1

15

High-throughput

0.457

High

1313396

X5D9H9
Aryl-hydrocarbon receptor nuclear translocator 2 isoform B

1

16

High-throughput

0.457

High

1313397

X5DP31
Aryl-hydrocarbon receptor nuclear translocator 2 isoform E

1

15

High-throughput

0.457

High

1313356

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

2

High-throughput

0.439

High

1146166

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

3257

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

High-throughput

0.417

High

3424

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

19

High-throughput

0.417

High

376306

ANXA1
Annexin A1

1

6

Small-scale

0.408

High

3523

DP2NB
DPEP2 neighbor protein

1

0

High-throughput

0.268

Low

92530

NPIA7
Nuclear pore complex-interacting protein family member A7

1

0

High-throughput

0.268

Low

154631

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.268

Low

1285947

Q96BU6
EXOC7 protein

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024