Protein: BIK
Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)

Gene: BIK
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q13323

Gene Ontology (top 5):
GO:0006915 - apoptotic process
GO:0008584 - male gonad development
GO:0008637 - apoptotic mitochondrial changes
GO:0012505 - endomembrane system
GO:0031334 - positive regulation of protein-containing complex assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060162

B2CL1
Bcl-2-like protein 1

12

6

Small-scale

0.760

High

1102429

B2CL2
Bcl-2-like protein 2

8

6

Small-scale

0.754

High

522086

BCL2
Apoptosis regulator Bcl-2

11

6

Small-scale

0.754

High

1102433

FATE1
Fetal and adult testis-expressed transcript protein

5

0

High-throughput

0.689

High

1102457

B2L10
Bcl-2-like protein 10

4

0

Small-scale

0.655

High

1102394

B2LA1
Bcl-2-related protein A1

5

4

Small-scale

0.653

High

1060255

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

3

5

Small-scale

0.639

High

1102458

TM14B
Transmembrane protein 14B

2

1

High-throughput

0.606

High

1102463

TM14C
Transmembrane protein 14C

2

1

High-throughput

0.606

High

1102469

STX8
Syntaxin-8

2

1

High-throughput

0.606

High

130085

PGRC1
Membrane-associated progesterone receptor component 1

2

0

High-throughput

0.580

High

688380

PPLA
Phospholamban

2

0

High-throughput

0.580

High

1092043

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

2

0

High-throughput

0.580

High

1102413

VMA12
Vacuolar ATPase assembly protein VMA12

2

0

High-throughput

0.580

High

1102459

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.580

High

1102474

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

High-throughput

0.580

High

230312

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

328665

VAMP5
Vesicle-associated membrane protein 5

2

2

High-throughput

0.553

High

336158

CNIH1
Protein cornichon homolog 1

2

1

High-throughput

0.553

High

883414

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

1

High-throughput

0.553

High

1050017

PLP2
Proteolipid protein 2

2

2

High-throughput

0.553

High

1102392

VAMP3
Vesicle-associated membrane protein 3

2

2

High-throughput

0.553

High

1102416

SERP2
Stress-associated endoplasmic reticulum protein 2

2

1

High-throughput

0.553

High

1102419

CNIH3
Protein cornichon homolog 3

2

1

High-throughput

0.553

High

1102439

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

2

High-throughput

0.553

High

1102455

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.553

High

1102476

SERP1
Stress-associated endoplasmic reticulum protein 1

2

1

High-throughput

0.553

High

855864

CRKL
Crk-like protein

1

0

High-throughput

0.518

High

1102411

TARG1
Trafficking regulator of GLUT4 1

1

1

High-throughput

0.481

High

422048

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

63652

A5PKU2
TUSC5 protein

1

1

High-throughput

0.470

High

1102435

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

1030356

PMP22
Peripheral myelin protein 22

1

0

High-throughput

0.460

High

1102390

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.460

High

219626

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.458

High

934560

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

997682

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.458

High

3216

A0A0S2Z3D2
Bcl-2-like protein 1

1

3

High-throughput

0.457

High

1102402

Q5T7Y6
Protein S100

1

1

High-throughput

0.451

High

160265

GOSR2
Golgi SNAP receptor complex member 2

1

1

High-throughput

0.439

High

179889

BET1
BET1 homolog

1

1

High-throughput

0.439

High

278498

VAMP4
Vesicle-associated membrane protein 4

1

1

High-throughput

0.439

High

295682

UPK1B
Uroplakin-1b

1

1

High-throughput

0.439

High

332990

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.439

High

657033

S10A1
Protein S100-A1

1

1

High-throughput

0.439

High

823936

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

1102397

ORML2
ORM1-like protein 2

1

1

High-throughput

0.439

High

1102443

REEP6
Receptor expression-enhancing protein 6

1

1

High-throughput

0.439

High

1102461

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.439

High

1102462

ORML1
ORM1-like protein 1

1

1

High-throughput

0.439

High

1102464

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

1

High-throughput

0.439

High

1102471

PLLP
Plasmolipin

1

2

High-throughput

0.439

High

74159

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.316

High

194825

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

2

0

High-throughput

0.316

High

209004

CYB5B
Cytochrome b5 type B

2

0

High-throughput

0.316

High

229228

G6PT1
Glucose-6-phosphate exchanger SLC37A4

2

0

High-throughput

0.316

High

327250

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.316

High

335546

BMP10
Bone morphogenetic protein 10

2

0

High-throughput

0.316

High

423771

APOD
Apolipoprotein D

2

0

High-throughput

0.316

High

553350

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

0

High-throughput

0.316

High

602212

TMM11
Transmembrane protein 11, mitochondrial

2

0

High-throughput

0.316

High

622051

CD53
Leukocyte surface antigen CD53

2

0

High-throughput

0.316

High

641462

CD72
B-cell differentiation antigen CD72

2

0

High-throughput

0.316

High

949240

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.316

High

1102391

GRM2
Metabotropic glutamate receptor 2

2

0

High-throughput

0.316

High

1102393

ADIPO
Adiponectin

2

0

High-throughput

0.316

High

1102395

EX3L2
Exocyst complex component 3-like protein 2

2

0

High-throughput

0.316

High

1102396

CTXN3
Cortexin-3

2

0

High-throughput

0.316

High

1102398

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.316

High

1102399

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.316

High

1102400

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

0

High-throughput

0.316

High

1102401

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1102403

TSPO2
Translocator protein 2

2

0

High-throughput

0.316

High

1102404

PLPP4
Phospholipid phosphatase 4

2

0

High-throughput

0.316

High

1102406

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.316

High

1102407

TM107
Transmembrane protein 107

2

0

High-throughput

0.316

High

1102408

S35E3
Solute carrier family 35 member E3

2

0

High-throughput

0.316

High

1102409

ANR46
Ankyrin repeat domain-containing protein 46

2

0

High-throughput

0.316

High

1102412

NRM
Nurim

2

0

High-throughput

0.316

High

1102414

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.316

High

1102415

CLD19
Claudin-19

2

0

High-throughput

0.316

High

1102417

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.316

High

1102418

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

1102420

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1102421

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.316

High

1102422

BT2A2
Butyrophilin subfamily 2 member A2

2

0

High-throughput

0.316

High

1102423

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

0

High-throughput

0.316

High

1102427

S39A7
Zinc transporter SLC39A7

2

0

High-throughput

0.316

High

1102428

FAM3C
Protein FAM3C

2

0

High-throughput

0.316

High

1102432

SCAM4
Secretory carrier-associated membrane protein 4

2

0

High-throughput

0.316

High

1102434

LFG3
Protein lifeguard 3

2

0

High-throughput

0.316

High

1102437

F241B
Protein FAM241B

2

0

High-throughput

0.316

High

1102438

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1102441

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

1102442

TMM80
Transmembrane protein 80

2

0

High-throughput

0.316

High

1102444

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

1102447

TM243
Transmembrane protein 243

2

0

High-throughput

0.316

High

1102448

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

2

0

High-throughput

0.316

High

1102451

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.316

High

1102452

TM222
Transmembrane protein 222

2

0

High-throughput

0.316

High

1102454

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

1102460

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

High-throughput

0.316

High

1102465

NAT8
N-acetyltransferase 8

2

0

High-throughput

0.316

High

1102466

PGAP2
Acyltransferase PGAP2

2

0

High-throughput

0.316

High

1102467

AGRE2
Adhesion G protein-coupled receptor E2

2

0

High-throughput

0.316

High

1102470

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

1102472

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.316

High

1102475

SELK
Selenoprotein K

2

0

High-throughput

0.316

High

1102425

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

Small-scale

0.301

High

665092

COT2
COUP transcription factor 2

1

0

High-throughput

0.282

High

1102430

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.282

High

155459

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.268

Low

516258

DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

1

0

High-throughput

0.268

Low

1055120

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.268

Low

1102410

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.268

Low

1102424

GIMA1
GTPase IMAP family member 1

1

0

High-throughput

0.268

Low

1102440

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.268

Low

1102445

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

High-throughput

0.268

Low

1102450

TACAN
Transmembrane protein 120A

1

0

High-throughput

0.268

Low

155936

SOCS3
Suppressor of cytokine signaling 3

1

0

High-throughput

0.251

Low

156554

C56D2
Transmembrane reductase CYB561D2

1

0

High-throughput

0.251

Low

226321

SNG1
Synaptogyrin-1

1

0

High-throughput

0.251

Low

341418

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.251

Low

665970

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.251

Low

719914

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.251

Low

1102446

YIPF4
Protein YIPF4

1

0

High-throughput

0.251

Low

1102449

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.251

Low

1102453

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.251

Low

1102456

AT131
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.251

Low

1102468

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.251

Low

1102473

PEX16
Peroxisomal membrane protein PEX16

1

0

High-throughput

0.251

Low

946731

RHBL3
Rhomboid-related protein 3

1

0

Small-scale

0.249

Low

1102426

ASB17
Ankyrin repeat and SOCS box protein 17

1

0

Small-scale

0.249

Low

1102431

CUL5
Cullin-5

1

0

Small-scale

0.249

Low

1102436

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

Small-scale

0.249

Low

1102405

S27A1
Long-chain fatty acid transport protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025