Protein: TRAF6
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)

Gene: TRAF6
Organism: Mus musculus
Interactions: 127
UniProt ID: P70196

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0001503 - ossification
GO:0001701 - in utero embryonic development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936216

TRAF6
TNF receptor-associated factor 6

5

20

Small-scale

0.912

High

896579

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

20

Small-scale

0.861

High

895974

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.776

High

936234

M3K7
Mitogen-activated protein kinase kinase kinase 7

10

17

Small-scale

0.750

High

607543

MYD88
Myeloid differentiation primary response protein MyD88

8

18

Small-scale

0.746

High

936236

IRAK1
Interleukin-1 receptor-associated kinase 1

8

12

Small-scale

0.746

High

936293

BAG6
Large proline-rich protein BAG6

2

13

Small-scale

0.743

High

936255

ITCH
E3 ubiquitin-protein ligase Itchy

4

20

Small-scale

0.694

High

192585

TNR11
Tumor necrosis factor receptor superfamily member 11A

4

20

Small-scale

0.681

High

648955

TNR5
Tumor necrosis factor receptor superfamily member 5

4

20

Small-scale

0.681

High

291787

NEMO
NF-kappa-B essential modulator

4

19

Small-scale

0.680

High

936247

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.665

High

936229

TNAP3
Tumor necrosis factor alpha-induced protein 3

3

19

Small-scale

0.662

High

936288

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

3

3

Small-scale

0.658

High

936243

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

3

11

Small-scale

0.657

High

936217

IRF7
Interferon regulatory factor 7

3

20

Small-scale

0.656

High

936233

M3K3
Mitogen-activated protein kinase kinase kinase 3

3

19

Small-scale

0.650

High

936237

SQSTM
Sequestosome-1

3

16

Small-scale

0.650

High

936285

TLR4
Toll-like receptor 4

3

10

Small-scale

0.650

High

936262

IRAK3
Interleukin-1 receptor-associated kinase 3

3

12

Small-scale

0.629

High

936263

CIKS
E3 ubiquitin ligase TRAF3IP2

3

12

Small-scale

0.629

High

936269

ARRB2
Beta-arrestin-2

2

3

Small-scale

0.624

High

936235

NR0B2
Nuclear receptor subfamily 0 group B member 2

2

7

Small-scale

0.621

High

936287

RNF11
RING finger protein 11

2

7

Small-scale

0.621

High

936244

TCAM1
TIR domain-containing adapter molecule 1

2

13

Small-scale

0.611

High

936224

TRAD1
TRAF-type zinc finger domain-containing protein 1

2

10

Small-scale

0.608

High

936223

NLRX1
NLR family member X1

2

20

Small-scale

0.601

High

936291

CHIP
E3 ubiquitin-protein ligase CHIP

2

14

Small-scale

0.601

High

936226

TAXB1
Tax1-binding protein 1 homolog

3

20

Small-scale

0.593

High

682105

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.584

High

880598

IRF5
Interferon regulatory factor 5

2

20

Small-scale

0.584

High

883704

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

2

20

Small-scale

0.584

High

936273

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

2

19

Small-scale

0.584

High

936274

TLR3
Toll-like receptor 3

2

10

Small-scale

0.584

High

925782

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

Small-scale

0.578

High

936259

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.575

High

936241

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

7

Small-scale

0.573

High

447077

ITB1
Integrin beta-1

1

5

Small-scale

0.561

High

578260

KS6A3
Ribosomal protein S6 kinase alpha-3

1

12

Small-scale

0.561

High

936238

MYSM1
Deubiquitinase MYSM1

1

11

Small-scale

0.561

High

936249

ARRB1
Beta-arrestin-1

1

3

Small-scale

0.561

High

936225

NTRK1
High affinity nerve growth factor receptor

1

12

Small-scale

0.554

High

936245

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.537

High

571853

HS71B
Heat shock 70 kDa protein 1B

1

20

Small-scale

0.534

High

936253

Q8C0E5
SEFIR domain-containing protein

1

12

Small-scale

0.529

High

250818

FHL2
Four and a half LIM domains protein 2

1

20

Small-scale

0.515

High

886050

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.515

High

936222

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

1

7

Small-scale

0.515

High

936256

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

1

Small-scale

0.515

High

936270

NRIF1
Neurotrophin receptor-interacting factor 1

1

20

Small-scale

0.515

High

936286

LIMD1
LIM domain-containing protein 1

1

20

Small-scale

0.515

High

936280

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

7

Small-scale

0.489

High

59961

A4FUW1
4932417H02Rik protein

1

14

Small-scale

0.479

High

101510

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

18

Small-scale

0.479

High

111226

I7GPR1
TRAF3 interacting protein 2

1

12

Small-scale

0.479

High

192444

TNF11
Tumor necrosis factor ligand superfamily member 11

1

8

Small-scale

0.479

High

291954

BECN1
Beclin-1

1

3

Small-scale

0.479

High

292696

CASP8
Caspase-8

1

20

Small-scale

0.479

High

393845

ALDOA
Fructose-bisphosphate aldolase A

1

3

Small-scale

0.479

High

403426

SRC
Proto-oncogene tyrosine-protein kinase Src

1

16

Small-scale

0.479

High

432421

HS90A
Heat shock protein HSP 90-alpha

1

13

Small-scale

0.479

High

486092

EF1A1
Elongation factor 1-alpha 1

1

9

Small-scale

0.479

High

513670

HS90B
Heat shock protein HSP 90-beta

1

14

Small-scale

0.479

High

562597

IL7RA
Interleukin-7 receptor subunit alpha

1

1

Small-scale

0.479

High

565424

HSP72
Heat shock-related 70 kDa protein 2

1

20

Small-scale

0.479

High

566045

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

588712

BIP
Endoplasmic reticulum chaperone BiP

1

20

Small-scale

0.479

High

610579

CBL
E3 ubiquitin-protein ligase CBL

1

15

Small-scale

0.479

High

618926

IRF8
Interferon regulatory factor 8

1

20

Small-scale

0.479

High

659680

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.479

High

715072

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

20

Small-scale

0.479

High

719291

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

9

Small-scale

0.479

High

751910

GRP75
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

815726

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

840019

VATA
V-type proton ATPase catalytic subunit A

1

5

Small-scale

0.479

High

854521

KPYM
Pyruvate kinase PKM

1

6

Small-scale

0.479

High

885074

ACTN4
Alpha-actinin-4

1

13

Small-scale

0.479

High

885394

EF2
Elongation factor 2

1

7

Small-scale

0.479

High

892159

ACTB
Actin, cytoplasmic 1

1

16

Small-scale

0.479

High

926117

HSP7C
Heat shock cognate 71 kDa protein

1

20

Small-scale

0.479

High

936220

SMN
Survival motor neuron protein

1

2

Small-scale

0.479

High

936221

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.479

High

936227

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

16

Small-scale

0.479

High

936228

ZC12A
Endoribonuclease ZC3H12A

1

6

Small-scale

0.479

High

936230

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

936231

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.479

High

936232

I17RA
Interleukin-17 receptor A

1

5

Small-scale

0.479

High

936239

MABP1
Mitogen-activated protein kinase-binding protein 1

1

9

Small-scale

0.479

High

936240

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.479

High

936242

ACTN1
Alpha-actinin-1

1

13

Small-scale

0.479

High

936248

TCAM2
TIR domain-containing adapter molecule 2

1

11

Small-scale

0.479

High

936250

TNR27
Tumor necrosis factor receptor superfamily member 27

1

10

Small-scale

0.479

High

936251

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

20

Small-scale

0.479

High

936252

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

20

Small-scale

0.479

High

936254

Q8C253
Galectin

1

12

Small-scale

0.479

High

936257

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

5

Small-scale

0.479

High

936258

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

12

Small-scale

0.479

High

936260

WDR24
GATOR2 complex protein WDR24

1

19

Small-scale

0.479

High

936261

CAR11
Caspase recruitment domain-containing protein 11

1

18

Small-scale

0.479

High

936264

TRI29
Tripartite motif-containing protein 29

1

20

Small-scale

0.479

High

936265

MAVS
Mitochondrial antiviral-signaling protein

1

16

Small-scale

0.479

High

936267

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

20

Small-scale

0.479

High

936268

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

11

Small-scale

0.479

High

936271

STK26
Serine/threonine-protein kinase 26

1

20

Small-scale

0.479

High

936272

ARP3
Actin-related protein 3

1

17

Small-scale

0.479

High

936275

CUL5
Cullin-5

1

20

Small-scale

0.479

High

936276

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

5

Small-scale

0.479

High

936278

TLR9
Toll-like receptor 9

1

10

Small-scale

0.479

High

936281

I17RB
Interleukin-17 receptor B

1

5

Small-scale

0.479

High

936282

PKHO1
Pleckstrin homology domain-containing family O member 1

1

1

Small-scale

0.479

High

936283

TNR19
Tumor necrosis factor receptor superfamily member 19

1

10

Small-scale

0.479

High

936284

MTOR
Serine/threonine-protein kinase mTOR

1

14

Small-scale

0.479

High

936289

DOK3
Docking protein 3

1

4

Small-scale

0.479

High

936290

VAV3
Guanine nucleotide exchange factor VAV3

1

12

Small-scale

0.479

High

936292

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.479

High

936279

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

20

Small-scale

0.470

High

392767

PRIO
Major prion protein

1

0

Small-scale

0.458

High

568433

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

Small-scale

0.458

High

936218

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

936246

I17RE
Interleukin-17 receptor E

1

0

Small-scale

0.458

High

536149

CALR
Calreticulin

1

3

High-throughput

0.457

High

936219

FHL1
Four and a half LIM domains protein 1

1

20

High-throughput

0.457

High

936266

PAXI
Paxillin

1

20

High-throughput

0.457

High

936277

OCAT1
POU domain class 2-associating factor 2

1

0

High-throughput

0.438

High

672762

MSRE
Macrophage scavenger receptor types I and II

1

8

Small-scale

0.437

High

880609

ATPB
ATP synthase subunit beta, mitochondrial

1

4

Small-scale

0.437

High


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Last updated: 15 Jul 2024