HitPredict

Interactor 1: CACO2 (Q13137)
Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
Gene: CALCOCO2

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	33815386, 21988832
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 446 Hs			1 419
+	Hs
		1025499 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1201960 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		551687 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		1201869 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		724805 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		725151 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		528370 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		1025488 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Mm
		1141846 EP15R_MOUSE (102-435): 2.36e-31: 129: 13.55		ITSN1_MOUSE (18-402): 2.09e-31: 129: 13.33
+	Hs
		1201957 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60
+	Hs
		1078923 EP15R_HUMAN (76-252): 1.67e-15: 80.9: 15.25		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		61738 EP15R_HUMAN (76-252): 1.67e-15: 80.9: 15.25		A6H8W8_HUMAN (29-380): 4.92e-17: 85.9: 11.67
+	Hs
		1378454 X5D7A4_HUMAN (114-440): 1.13e-13: 75.5: 12.14		X5D7A4_HUMAN (29-238): 1e-17: 87.8: 18.61
+	Hs
		305096 RIMB1_HUMAN (85-440): 7.36e-19: 91.7: 10.00		RIMB1_HUMAN (31-362): 3.69e-10: 64.3: 14.99
+	Rn
		222476 MRCKA_RAT (81-439): 8.89e-16: 82.1: 10.80		MRCKB_RAT (45-355): 2.08e-10: 65: 14.56
+	Rn
		222472 MRCKA_RAT (81-439): 8.89e-16: 82.1: 10.80		MRCKA_RAT (77-391): 2.29e-09: 61.9: 16.30
+	Hs
		1137871 MRCKA_HUMAN (213-416): 6.71e-11: 66.7: 10.28		MRCKA_HUMAN (32-363): 1.19e-13: 75.1: 15.89
+	Rn
		1186812 MRCKB_RAT (123-433): 1.73e-11: 68.6: 14.62		MRCKB_RAT (45-355): 2.08e-10: 65: 14.56
+	Hs
		1137917 MRCKA_HUMAN (213-416): 6.71e-11: 66.7: 10.28		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60