Protein: 2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)

Gene: 2A5E, PPP2R5E
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q16537

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717828

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

9

20

High-throughput

0.977

High

994236

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

7

20

Small-scale

0.971

High

977504

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

6

20

High-throughput

0.953

High

718127

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

3

20

Small-scale

0.858

High

1143882

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

8

High-throughput

0.789

High

364140

MOS
Proto-oncogene serine/threonine-protein kinase mos

4

1

High-throughput

0.699

High

909279

CCNG1
Cyclin-G1

3

13

High-throughput

0.667

High

1025620

CDK17
Cyclin-dependent kinase 17

3

3

High-throughput

0.667

High

69782

ZN785
Zinc finger protein 785

3

1

High-throughput

0.662

High

967761

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

17

High-throughput

0.656

High

1158047

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

8

High-throughput

0.656

High

1158090

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.638

High

327275

ZFPL1
Zinc finger protein-like 1

3

0

High-throughput

0.634

High

942157

WNT3A
Protein Wnt-3a

4

4

High-throughput

0.630

High

1158066

FA43A
Protein FAM43A

4

4

High-throughput

0.630

High

324263

FA13A
Protein FAM13A

3

4

Small-scale

0.629

High

1158058

MARK2
Serine/threonine-protein kinase MARK2

2

3

High-throughput

0.628

High

1103125

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

8

High-throughput

0.618

High

1158070

DNS2B
Deoxyribonuclease-2-beta

3

2

High-throughput

0.609

High

1158060

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

3

High-throughput

0.604

High

894305

CRIP1
Cysteine-rich protein 1

2

0

High-throughput

0.602

High

1158055

ZN517
Zinc finger protein 517

2

0

High-throughput

0.602

High

1158092

KLF15
Krueppel-like factor 15

2

0

High-throughput

0.602

High

1158051

SGO1
Shugoshin 1

2

4

High-throughput

0.601

High

1158076

LPAR4
Lysophosphatidic acid receptor 4

2

1

High-throughput

0.574

High

1158078

PRR14
Proline-rich protein 14

2

3

High-throughput

0.574

High

1158083

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.574

High

396200

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1158071

BAD
Bcl2-associated agonist of cell death

2

1

High-throughput

0.571

High

354993

CHK2
Serine/threonine-protein kinase Chk2

1

6

Small-scale

0.552

High

1158081

RGAP1
Rac GTPase-activating protein 1

1

0

Small-scale

0.549

High

1158085

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

Small-scale

0.549

High

840717

RS27
Small ribosomal subunit protein eS27

1

1

High-throughput

0.536

High

853274

CBX5
Chromobox protein homolog 5

1

2

Small-scale

0.536

High

1158088

KLH14
Kelch-like protein 14

1

3

High-throughput

0.536

High

1158061

DZIP1
Cilium assembly protein DZIP1

1

9

Small-scale

0.529

High

445901

ENOA
Alpha-enolase

1

0

High-throughput

0.518

High

1123506

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

1158079

DOCK9
Dedicator of cytokinesis protein 9

1

0

High-throughput

0.518

High

1158067

ZN276
Zinc finger protein 276

1

0

High-throughput

0.513

High

1158072

ELP4
Elongator complex protein 4

1

0

High-throughput

0.513

High

1158077

SPXN
Spexin

1

0

High-throughput

0.513

High

1158095

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

902783

RORG
Nuclear receptor ROR-gamma

1

1

High-throughput

0.508

High

995059

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.508

High

185736

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

422177

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1158086

DDX56
Probable ATP-dependent RNA helicase DDX56

1

0

High-throughput

0.493

High

843594

HD
Huntingtin

1

0

High-throughput

0.493

High

1088772

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

2

High-throughput

0.489

High

1158052

MTCL3
Microtubule cross-linking factor 3

1

4

High-throughput

0.489

High

1158057

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

7

High-throughput

0.489

High

1158082

CA021
Uncharacterized protein C1orf21

1

2

High-throughput

0.489

High

1158093

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.489

High

1158096

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

6

High-throughput

0.489

High

181894

SMAD9
Mothers against decapentaplegic homolog 9

1

0

High-throughput

0.486

High

192926

CLOCK
Circadian locomoter output cycles protein kaput

1

1

High-throughput

0.481

High

251768

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

7

Small-scale

0.481

High

885786

KC1E
Casein kinase I isoform epsilon

1

2

High-throughput

0.481

High

1157643

CRY1
Cryptochrome-1

1

3

High-throughput

0.481

High

1158049

CRY2
Cryptochrome-2

1

3

High-throughput

0.481

High

1158080

BHE41
Class E basic helix-loop-helix protein 41

1

3

High-throughput

0.481

High

1158094

FBW1B
F-box/WD repeat-containing protein 11

1

1

High-throughput

0.481

High

241808

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

342199

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

363340

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

588805

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

695574

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

1004622

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1052028

CALD1
Caldesmon

1

2

High-throughput

0.479

High

1086858

CDC20
Cell division cycle protein 20 homolog

1

2

Small-scale

0.479

High

1113210

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1158048

CCNG2
Cyclin-G2

1

13

High-throughput

0.479

High

1158054

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1158056

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1158084

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

1158087

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1158091

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

315635

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

1135691

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

154987

BHE40
Class E basic helix-loop-helix protein 40

1

2

High-throughput

0.457

High

529878

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

1153388

CD226
CD226 antigen

1

4

High-throughput

0.445

High

1158050

SGO2
Shugoshin 2

1

2

Small-scale

0.445

High

1158059

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

2

High-throughput

0.445

High

1158064

KSR1
Kinase suppressor of Ras 1

1

5

Small-scale

0.445

High

1158074

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.445

High

1158089

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

418159

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

768300

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1035649

KIF23
Kinesin-like protein KIF23

1

0

Small-scale

0.426

High

262236

SCN2B
Sodium channel regulatory subunit beta-2

1

6

High-throughput

0.407

High

1158068

Q8N5D4
Cyclin-G2

1

13

High-throughput

0.407

High

1158053

CXB7
Gap junction beta-7 protein

2

0

High-throughput

0.328

High

1158062

C1QL4
Complement C1q-like protein 4

2

0

High-throughput

0.328

High

1158069

DCA11
DDB1- and CUL4-associated factor 11

2

0

High-throughput

0.328

High

1158075

DCR1C
Protein artemis

2

0

High-throughput

0.318

High

1158063

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.304

High

706136

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

1081580

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.279

Low

1158065

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

1158073

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

255044

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025