HitPredict

Interactor 1: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 236
+	Hs
		1026182 PAK1_HUMAN (1-545): 0: 558: 100.00		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		950963 PAK1_HUMAN (1-545): 0: 558: 100.00		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		925244 PAK1_HUMAN (1-545): 0: 558: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Mm
		103566 G5E884_MOUSE (1-545): 0: 553: 98.90		RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23
+	Mm
		292040 PAK1_MOUSE (1-545): 0: 552: 97.62		RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23
+	Hs
		892345 PAK1_HUMAN (1-545): 0: 558: 100.00		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564505 PAK1_HUMAN (1-545): 0: 558: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545350 PAK1_HUMAN (1-545): 0: 558: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Mm
		103575 G5E884_MOUSE (1-545): 0: 553: 98.90		RHOQ_MOUSE (23-236): 1.07e-73: 224: 50.47
+	Mm
		103567 G5E884_MOUSE (1-545): 0: 553: 98.90		RAC2_MOUSE (32-216): 3.97e-73: 222: 52.43
+	Mm
		292041 PAK1_MOUSE (1-545): 0: 552: 97.62		RAC2_MOUSE (32-216): 3.97e-73: 222: 52.43
+	Mm
		292048 PAK1_MOUSE (1-545): 0: 552: 97.62		RHOA_MOUSE (33-215): 8.53e-73: 221: 42.62
+	Hs
		893957 PAK1_HUMAN (1-545): 0: 558: 100.00		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Rn
		723755 PAK1_RAT (1-545): 0: 554: 98.72		CDC42_RAT (32-207): 2.12e-66: 205: 57.39
+	Mm
		103565 G5E884_MOUSE (1-545): 0: 553: 98.90		CDC42_MOUSE (32-207): 2.12e-66: 205: 57.39
+	Mm
		292039 PAK1_MOUSE (1-545): 0: 552: 97.62		CDC42_MOUSE (32-207): 2.12e-66: 205: 57.39
+	Hs
		1026226 PAK1_HUMAN (1-545): 0: 558: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Mm
		925809 PAK2_MOUSE (1-544): 4.73e-169: 491: 74.82		RAC1_MOUSE (32-217): 3.34e-76: 230: 53.23
+	Hs
		545351 PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Rn
		1145152 PAK2_RAT (1-544): 6.7e-169: 490: 74.82		CDC42_RAT (32-207): 2.12e-66: 205: 57.39