Protein: WNK3
Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)

Gene: WNK3
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q9BYP7

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1418959

WNK1
Serine/threonine-protein kinase WNK1

3

17

High-throughput

0.861

High

171756

GAK
Cyclin-G-associated kinase

1

17

High-throughput

0.691

High

187175

PPM1G
Protein phosphatase 1G

1

5

High-throughput

0.691

High

343639

OXSR1
Serine/threonine-protein kinase OSR1

1

19

High-throughput

0.691

High

1418960

BMP2K
BMP-2-inducible protein kinase

1

20

High-throughput

0.691

High

1418963

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

19

High-throughput

0.691

High

1418966

WNK2
Serine/threonine-protein kinase WNK2

1

17

High-throughput

0.691

High

1418964

KLHL3
Kelch-like protein 3

4

9

Small-scale

0.686

High

1418965

T22D4
TSC22 domain family protein 4

3

16

High-throughput

0.667

High

329101

KLHL2
Kelch-like protein 2

3

9

Small-scale

0.656

High

163159

CHK1
Serine/threonine-protein kinase Chk1

1

13

High-throughput

0.618

High

1255403

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1324073

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.618

High

1048990

REL
Proto-oncogene c-Rel

2

7

High-throughput

0.606

High

483389

CLCB
Clathrin light chain B

2

7

High-throughput

0.558

High

135989

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

4

High-throughput

0.536

High

175194

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.536

High

271740

HIP1R
Huntingtin-interacting protein 1-related protein

1

3

High-throughput

0.536

High

347300

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

682599

S100P
Protein S100-P

1

6

High-throughput

0.536

High

839818

EPS15
Epidermal growth factor receptor substrate 15

1

3

High-throughput

0.536

High

1026207

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.536

High

1123096

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1145919

RBP1
RalA-binding protein 1

1

6

High-throughput

0.536

High

1386690

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.536

High

1387110

REPS1
RalBP1-associated Eps domain-containing protein 1

1

4

High-throughput

0.536

High

840088

CASP3
Caspase-3

1

4

Small-scale

0.515

High

1407555

TCPH
T-complex protein 1 subunit eta

1

6

High-throughput

0.515

High

1013104

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

323779

AP2A2
AP-2 complex subunit alpha-2

1

7

High-throughput

0.489

High

344785

AP2A1
AP-2 complex subunit alpha-1

1

7

High-throughput

0.489

High

548596

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.489

High

922495

CLH2
Clathrin heavy chain 2

1

4

High-throughput

0.489

High

989106

AP2B1
AP-2 complex subunit beta

1

6

High-throughput

0.489

High

1083307

AP1B1
AP-1 complex subunit beta-1

1

6

High-throughput

0.489

High

1129874

EPN4
Clathrin interactor 1

1

1

High-throughput

0.489

High

1360371

STON2
Stonin-2

1

3

High-throughput

0.489

High

1399667

TGM7
Protein-glutamine gamma-glutamyltransferase Z

1

1

High-throughput

0.489

High

1418958

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.489

High

1418967

EPN1
Epsin-1

1

1

High-throughput

0.489

High

773001

MYH9
Myosin-9

1

2

High-throughput

0.479

High

1049740

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1121871

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

6

High-throughput

0.479

High

1156201

ZYX
Zyxin

1

4

High-throughput

0.479

High

1400005

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

16

Small-scale

0.479

High

173316

XPO1
Exportin-1

1

8

High-throughput

0.445

High

273283

T22D2
TSC22 domain family protein 2

1

16

Small-scale

0.439

High

483205

CLCA
Clathrin light chain A

1

7

High-throughput

0.437

High

1276745

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1388637

SPDLY
Protein Spindly

1

12

High-throughput

0.437

High

94328

D6R9G5
Kelch like family member 2

1

11

High-throughput

0.407

High

916134

LBX1
Transcription factor LBX1

2

0

High-throughput

0.316

High

1418962

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.279

Low

595585

H15
Histone H1.5

1

0

High-throughput

0.269

Low

1249192

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1358195

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.249

Low

1418961

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025