HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: ADNP2 (Q6IQ32)
Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508)
Gene: ADNP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.734

Property	Details
Experiments	32296183, 27705803, 34079125, 33961781, 21888893, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1131
+	Hs
		800419 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		ADNP2_HUMAN (1-1131): 0: 1195: 100.00
+	Mm
		1208472 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		ADNP2_MOUSE (1-1127): 0: 1126: 77.49
+	Hs
		1027253 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		ADNP_HUMAN (1-406): 3.09e-126: 415: 27.02
+	Mm
		1169697 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		Q6ZQ47_MOUSE (20-406): 2.53e-111: 375: 25.91
+	Mm
		1143028 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		Q6ZQ47_MOUSE (20-406): 2.53e-111: 375: 25.91
+	Hs
		1027086 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		POGZ_HUMAN (302-905): 2.09e-60: 229: 14.65
+	Mm
		1207522 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		POGZ_MOUSE (302-905): 5.58e-57: 218: 14.65
+	Hs
		800440 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		POGZ_HUMAN (302-905): 2.09e-60: 229: 14.65
+	Mm
		1143032 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		POGZ_MOUSE (302-905): 5.58e-57: 218: 14.65
+	Mm
		1225198 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		CHAP1_MOUSE (149-749): 8e-33: 139: 14.08
+	Mm
		1159591 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		Z280C_MOUSE (521-904): 9e-27: 119: 16.40
+	Hs
		1027056 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		Z280D_HUMAN (541-901): 1.11e-24: 113: 14.82
+	Hs
		1027135 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		Z280C_HUMAN (531-903): 6.44e-24: 110: 13.08
+	Mm
		1148418 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		Z280D_MOUSE (604-901): 4.23e-23: 108: 16.18
+	Mm
		1143037 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		CHAP1_MOUSE (149-749): 8e-33: 139: 14.08
+	Mm
		1143025 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		Z280C_MOUSE (521-904): 9e-27: 119: 16.40
+	Hs
		800422 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		Z280D_HUMAN (541-901): 1.11e-24: 113: 14.82
+	Mm
		1143024 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		Z280D_MOUSE (604-901): 4.23e-23: 108: 16.18
+	Hs
		1026998 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		MDC1_HUMAN (254-681): 2.36e-10: 67.2: 13.44
+	Hs
		1027191 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		CHAP1_HUMAN (326-748): 2.4e-10: 66.9: 11.77