Protein: TMPPE
Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-)

Gene: TMPPE
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q6ZT21

Gene Ontology (top 5):
GO:0016020 - membrane
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1254318

SCN3B
Sodium channel regulatory subunit beta-3

3

0

High-throughput

0.793

High

1254310

P2Y12
P2Y purinoceptor 12

3

2

High-throughput

0.667

High

1254302

SLAF6
SLAM family member 6

2

0

High-throughput

0.655

High

733702

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

2

High-throughput

0.628

High

1254300

5HT3C
5-hydroxytryptamine receptor 3C

3

3

High-throughput

0.609

High

878044

AGRE5
Adhesion G protein-coupled receptor E5

2

0

High-throughput

0.602

High

1254312

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

2

0

High-throughput

0.602

High

1254317

CC50A
Cell cycle control protein 50A

2

0

High-throughput

0.585

High

883423

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.580

High

1154657

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.580

High

1229383

LEMD1
LEM domain-containing protein 1

2

0

High-throughput

0.580

High

1254299

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

1254311

S38A1
Sodium-coupled neutral amino acid symporter 1

2

0

High-throughput

0.580

High

1254313

TMM60
Transmembrane protein 60

2

0

High-throughput

0.580

High

1254322

PLLP
Plasmolipin

2

0

High-throughput

0.580

High

1254323

FIS1
Mitochondrial fission 1 protein

2

0

High-throughput

0.580

High

1254326

IR3IP
Immediate early response 3-interacting protein 1

2

0

High-throughput

0.580

High

1254305

TM169
Transmembrane protein 169

2

0

High-throughput

0.576

High

702795

5HT2C
5-hydroxytryptamine receptor 2C

2

1

High-throughput

0.574

High

1159071

C3AR
C3a anaphylatoxin chemotactic receptor

2

2

High-throughput

0.574

High

688581

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

1

High-throughput

0.553

High

762138

CNR2
Cannabinoid receptor 2

2

1

High-throughput

0.553

High

1254297

GP152
Probable G-protein coupled receptor 152

2

3

High-throughput

0.553

High

1254306

REEP6
Receptor expression-enhancing protein 6

2

2

High-throughput

0.553

High

1101547

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

1

High-throughput

0.549

High

851148

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

2

High-throughput

0.536

High

1085331

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

High-throughput

0.536

High

1185810

PTHD3
Patched domain-containing protein 3

1

1

High-throughput

0.536

High

63669

A5PKU2
TUSC5 protein

1

1

High-throughput

0.515

High

132613

UPK1A
Uroplakin-1a

1

0

High-throughput

0.513

High

1027053

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.489

High

1057552

ACHD
Acetylcholine receptor subunit delta

1

2

High-throughput

0.489

High

1197804

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.489

High

1254307

S39A8
Metal cation symporter ZIP8

1

1

High-throughput

0.489

High

596496

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.481

High

1254292

TARG1
Trafficking regulator of GLUT4 1

1

1

High-throughput

0.481

High

1254316

REEP4
Receptor expression-enhancing protein 4

1

2

High-throughput

0.470

High

1254293

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.460

High

1254301

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.437

High

211142

CTR4
Cationic amino acid transporter 4

1

0

High-throughput

0.426

High

256062

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

704029

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

835305

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.407

High

907092

CCR9
C-C chemokine receptor type 9

1

1

High-throughput

0.407

High

455982

ASGR2
Asialoglycoprotein receptor 2

4

0

High-throughput

0.361

High

1254304

BSCL2
Seipin

4

0

High-throughput

0.360

High

931386

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

3

0

High-throughput

0.347

High

1155153

EREP1
Endosomal transmembrane epsin interactor 1

3

0

High-throughput

0.347

High

838528

GRIA3
Glutamate receptor 3

2

0

High-throughput

0.328

High

1254291

S22A9
Organic anion transporter 7

2

0

High-throughput

0.328

High

1254319

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

549452

CD20
B-lymphocyte antigen CD20

2

0

High-throughput

0.316

High

549808

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

870053

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

928862

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.316

High

946327

CLRN1
Clarin-1

2

0

High-throughput

0.316

High

1081318

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.316

High

1100682

STX3
Syntaxin-3

2

0

High-throughput

0.316

High

1208712

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

1247356

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.316

High

1254289

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.316

High

1254294

CLDN2
Claudin domain-containing protein 2

2

0

High-throughput

0.316

High

1254295

PLPR1
Phospholipid phosphatase-related protein type 1

2

0

High-throughput

0.316

High

1254296

SFXN5
Sideroflexin-5

2

0

High-throughput

0.316

High

1254308

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.316

High

1254321

STX8
Syntaxin-8

2

0

High-throughput

0.316

High

1254325

YIPF1
Protein YIPF1

2

0

High-throughput

0.316

High

771781

SCN4A
Sodium channel protein type 4 subunit alpha

1

0

High-throughput

0.279

Low

1248762

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.279

Low

1254290

TMPSC
Transmembrane protease serine 12

1

0

High-throughput

0.279

Low

1254303

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

1254309

WNT8A
Protein Wnt-8a

1

0

High-throughput

0.279

Low

1254320

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

242071

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

647371

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.249

Low

1254314

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1254315

SG196
Protein O-mannose kinase

1

0

High-throughput

0.249

Low

139248

UPK2
Uroplakin-2

1

0

High-throughput

0.232

Low

1254298

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.232

Low

1254324

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025