HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: BCOR (Q6W2J9)
BCL-6 corepressor (BCoR)
Gene: BCOR

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24981860, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1755
+	Hs
		800429 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		327848 CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		123268 CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		316069 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		BCOR_HUMAN (1-1755): 0: 2385: 100.00
+	Hs
		1027031 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Mm
		1125433 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EHMT1_MOUSE (1226-1635): 8.01e-66: 248: 15.31
+	Hs
		1027268 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Hs
		1027218 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		BARD1_HUMAN (1144-1611): 3.52e-62: 230: 19.72
+	Hs
		316049 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		1125904 CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00		BCORL_HUMAN (1025-1743): 3.64e-88: 321: 34.63
+	Hs
		800530 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Mm
		949933 CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33		EHMT1_MOUSE (1226-1635): 8.01e-66: 248: 15.31
+	Hs
		949889 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Hs
		800503 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BARD1_HUMAN (1144-1611): 3.52e-62: 230: 19.72
+	Hs
		949868 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		BARD1_HUMAN (1144-1611): 3.52e-62: 230: 19.72
+	Hs
		1331975 SUV92_HUMAN (6-156): 4.05e-43: 149: 25.15		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Hs
		203794 SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Hs
		257534 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		ANR17_HUMAN (1289-1753): 3.43e-67: 254: 13.21
+	Hs
		1334148 CDY2_HUMAN (27-124): 2.81e-26: 106: 28.16		EHMT1_HUMAN (1226-1631): 1.56e-64: 244: 15.87
+	Hs
		316086 CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78		ANKH1_HUMAN (1155-1749): 2.19e-52: 206: 13.64