HitPredict

Interactor 1: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.913

Property	Details
Experiments	32296183, 30442662, 33277362, 27114451, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 908 Hs			1 624
+	Hs
		1027821 PSMD2_HUMAN (1-908): 0: 1290: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1027806 PSMD2_HUMAN (1-908): 0: 1290: 100.00		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		1027733 PSMD2_HUMAN (1-908): 0: 1290: 100.00		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		1027692 PSMD2_HUMAN (1-908): 0: 1290: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Dm
		1374998 Q9VW54_DROME (3-906): 0: 1063: 60.65		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		923974 PSMD2_HUMAN (1-908): 0: 1290: 100.00		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Hs
		1303948 PSMD1_HUMAN (59-845): 0: 790: 17.31		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1303954 PSMD1_HUMAN (59-845): 0: 790: 17.31		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Dm
		1362832 Q9VW54_DROME (3-906): 0: 1063: 60.65		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Hs
		1303937 PSMD1_HUMAN (59-845): 0: 790: 17.31		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Sp
		953205 RPN1_SCHPO (8-905): 0: 1025: 47.67		DSK2_SCHPO (33-240): 1.27e-27: 116: 23.26
+	Dm
		1359018 PSMD1_DROME (59-845): 0: 710: 17.07		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Sc
		753873 RPN1_YEAST (49-906): 0: 869: 37.71		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19
+	Hs
		1259550 PSMD1_HUMAN (59-845): 0: 790: 17.31		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		1136649 PSMD1_HUMAN (59-845): 0: 790: 17.31		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		924124 PSMD1_HUMAN (59-845): 0: 790: 17.31		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27