HitPredict

Interactor 1: DDX10 (Q13206)
Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10)
Gene: DDX10

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 875 Hs			1 272
+	Hs
		992749 DDX10_HUMAN (1-875): 0: 576: 100.00		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		993699 DDX10_HUMAN (1-875): 0: 576: 100.00		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		1027880 DDX10_HUMAN (1-875): 0: 576: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		1028843 DDX18_HUMAN (15-556): 5.31e-149: 456: 38.57		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		1029127 DDX18_HUMAN (15-556): 5.31e-149: 456: 38.57		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		1029007 DDX55_HUMAN (70-627): 7.77e-150: 455: 33.89		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Mm
		1208005 DDX18_MOUSE (4-562): 2.43e-151: 461: 37.46		RBM4_MOUSE (2-122): 2.58e-17: 82.4: 21.49
+	Hs
		1271643 DDX17_HUMAN (8-507): 1.66e-135: 423: 25.34		RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50
+	Hs
		571581 DDX5_HUMAN (2-503): 3.11e-133: 413: 25.78		RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50
+	Sc
		376628 DBP4_YEAST (31-688): 1.51e-131: 413: 40.66		PABP_YEAST (86-192): 7.08e-15: 75.9: 19.64
+	Mm
		857323 DDX17_MOUSE (8-507): 3.35e-134: 417: 25.34		TIA1_MOUSE (2-101): 7.98e-13: 69.3: 15.69
+	Sc
		376580 DED1_YEAST (18-473): 2.54e-131: 408: 26.25		PABP_YEAST (86-192): 7.08e-15: 75.9: 19.64
+	Mm
		857351 Q8BTS0_MOUSE (2-503): 8.53e-133: 412: 25.59		TIA1_MOUSE (2-101): 7.98e-13: 69.3: 15.69
+	Mm
		936480 DDX5_MOUSE (2-503): 7.38e-134: 415: 25.59		TIAR_MOUSE (100-193): 5.2e-11: 64.3: 16.67
+	Hs
		134018 DDX3X_HUMAN (1-453): 1.81e-123: 389: 26.88		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		133858 DDX3X_HUMAN (1-453): 1.81e-123: 389: 26.88		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		992938 DDX31_HUMAN (92-509): 4.25e-64: 233: 34.20		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1028823 DDX31_HUMAN (92-509): 4.25e-64: 233: 34.20		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		993834 DDX31_HUMAN (92-509): 4.25e-64: 233: 34.20		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		1029098 DDX31_HUMAN (92-509): 4.25e-64: 233: 34.20		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96