Protein: RYR2
Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)

Gene: RYR2
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q92736

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0002027 - regulation of heart rate
GO:0003143 - embryonic heart tube morphogenesis
GO:0003220 - left ventricular cardiac muscle tissue morphogenesis
GO:0003300 - cardiac muscle hypertrophy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

996423

FKB1B
Peptidyl-prolyl cis-trans isomerase FKBP1B

4

10

Small-scale

0.900

High

1367835

RYR2
Ryanodine receptor 2

3

16

Small-scale

0.861

High

641344

RYR1
Ryanodine receptor 1

2

17

Small-scale

0.799

High

721163

SORCN
Sorcin

2

7

Small-scale

0.768

High

605766

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

12

Small-scale

0.724

High

194841

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

3

Small-scale

0.647

High

650565

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

12

Small-scale

0.647

High

651692

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

12

Small-scale

0.647

High

1032076

CAC1D
Voltage-dependent L-type calcium channel subunit alpha-1D

1

10

Small-scale

0.647

High

1092849

AKAP6
A-kinase anchor protein 6

1

12

Small-scale

0.647

High

1119233

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

Small-scale

0.647

High

568271

PLST
Plastin-3

1

7

High-throughput

0.618

High

986860

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

10

Small-scale

0.618

High

1110520

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

11

Small-scale

0.618

High

1148270

RYR3
Ryanodine receptor 3

1

16

Small-scale

0.618

High

824269

RL13A
Large ribosomal subunit protein uL13

2

4

High-throughput

0.584

High

1028315

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.578

High

144187

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

10

Small-scale

0.561

High

390126

ALBU
Albumin

1

2

High-throughput

0.536

High

564150

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

1104796

SNTA1
Alpha-1-syntrophin

1

2

Small-scale

0.536

High

1367837

SMAD5
Mothers against decapentaplegic homolog 5

1

6

High-throughput

0.508

High

890026

PSN1
Presenilin-1

1

1

Small-scale

0.501

High

1295202

HOME1
Homer protein homolog 1

1

10

Small-scale

0.501

High

1360706

JPH3
Junctophilin-3

1

4

Small-scale

0.501

High

1367836

JPH4
Junctophilin-4

1

4

Small-scale

0.501

High

404286

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

482944

TPM1
Tropomyosin alpha-1 chain

1

4

High-throughput

0.479

High

620501

NUCL
Nucleolin

1

4

High-throughput

0.479

High

783360

TRI23
E3 ubiquitin-protein ligase TRIM23

1

5

High-throughput

0.479

High

904044

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

995456

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.479

High

1098528

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

5

Small-scale

0.479

High

1149947

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

1063491

GOGA2
Golgin subfamily A member 2

1

15

High-throughput

0.470

High

1156312

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

616219

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

1367838

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

19

High-throughput

0.457

High

138514

BIN1
Myc box-dependent-interacting protein 1

1

3

High-throughput

0.457

High

322511

ABLM3
Actin-binding LIM protein 3

1

3

High-throughput

0.437

High

447821

TPM3
Tropomyosin alpha-3 chain

1

3

High-throughput

0.437

High

464192

TPM2
Tropomyosin beta chain

1

3

High-throughput

0.437

High

783115

ARL2
ADP-ribosylation factor-like protein 2

1

3

High-throughput

0.437

High

928505

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.437

High

1227185

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.437

High

1338877

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.437

High

1367839

SAR1A
Small COPII coat GTPase SAR1A

1

5

High-throughput

0.437

High

1367840

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.437

High


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Last updated: 11Aug2025