HitPredict

Interactor 1: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34251884, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~Pkinase, MMS1_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1512 Hs			1 1140
+	Hs
		166564 DCLK1_HUMAN (996-1511): 1.41e-117: 389: 15.27		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Dm
		1213442 AKT1_DROME (970-1510): 8.64e-126: 407: 17.03		DDB1_DROME (1-1140): 0: 1237: 60.84
+	Hs
		1082353 M3K3_HUMAN (1243-1505): 1.2e-51: 195: 44.03		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Dm
		1213429 AKT1_DROME (970-1510): 8.64e-126: 407: 17.03		SF3B3_DROME (3-1126): 0: 1123: 20.68
+	Hs
		625453 CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Dm
		1213363 AKT1_DROME (970-1510): 8.64e-126: 407: 17.03		Q8T9L6_DROME (517-1126): 0: 610: 19.28