Protein: GLIS2
Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein)

Gene: GLIS2
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q9BZE0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

217197

MS18B
Protein Mis18-beta

2

1

High-throughput

0.783

High

1083433

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

3

Small-scale

0.698

High

1419617

WNK1
Serine/threonine-protein kinase WNK1

1

5

Small-scale

0.698

High

942860

BCAR1
Breast cancer anti-estrogen resistance protein 1

3

2

Small-scale

0.677

High

401439

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.647

High

549231

CDK4
Cyclin-dependent kinase 4

1

9

High-throughput

0.647

High

624524

WT1
Wilms tumor protein

1

17

High-throughput

0.647

High

728418

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.647

High

858711

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

12

High-throughput

0.647

High

912515

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

12

High-throughput

0.647

High

1025420

CDK6
Cyclin-dependent kinase 6

1

8

High-throughput

0.647

High

1097113

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

12

High-throughput

0.647

High

1154439

STK11
Serine/threonine-protein kinase STK11

1

3

High-throughput

0.647

High

1333287

GLIS1
Zinc finger protein GLIS1

1

18

High-throughput

0.647

High

1406380

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

11

High-throughput

0.647

High

1419616

GLIS2
Zinc finger protein GLIS2

1

17

High-throughput

0.647

High

1419620

LATS2
Serine/threonine-protein kinase LATS2

1

4

High-throughput

0.647

High

184770

SHOX
Short stature homeobox protein

2

8

High-throughput

0.606

High

210111

CRX
Cone-rod homeobox protein

2

11

High-throughput

0.606

High

330302

VENTX
Homeobox protein VENTX

2

17

High-throughput

0.606

High

921058

FOSB
Protein FosB

2

4

High-throughput

0.606

High

941544

CTBP2
C-terminal-binding protein 2

2

3

High-throughput

0.606

High

943310

RBM11
Splicing regulator RBM11

2

4

High-throughput

0.606

High

1007983

PO6F2
POU domain, class 6, transcription factor 2

2

11

High-throughput

0.606

High

1040646

CREM
cAMP-responsive element modulator

2

7

High-throughput

0.606

High

1044708

ARI5A
AT-rich interactive domain-containing protein 5A

2

3

High-throughput

0.606

High

1061860

TLE5
TLE family member 5

2

4

High-throughput

0.606

High

1358160

TWST2
Twist-related protein 2

2

7

High-throughput

0.606

High

1372072

RBPMS
RNA-binding protein with multiple splicing

2

1

High-throughput

0.606

High

1419622

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.606

High

1419624

PKHB1
Pleckstrin homology domain-containing family B member 1

2

1

High-throughput

0.606

High

1419625

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.606

High

1419628

NDK7
Nucleoside diphosphate kinase homolog 7

2

1

High-throughput

0.606

High

765013

CTNB1
Catenin beta-1

1

12

Small-scale

0.592

High

284347

GEMI
Geminin

2

0

High-throughput

0.580

High

963367

PFD3
Prefoldin subunit 3

2

0

High-throughput

0.580

High

995249

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.580

High

1203495

ACTMP
Actin maturation protease

2

0

High-throughput

0.580

High

1093414

TRI32
E3 ubiquitin-protein ligase TRIM32

1

15

Small-scale

0.561

High

50354

F168B
Myelin-associated neurite-outgrowth inhibitor

2

1

High-throughput

0.553

High

65157

GG6L9
Golgin subfamily A member 6-like protein 9

2

16

High-throughput

0.553

High

725454

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

5

High-throughput

0.553

High

1061551

ACTN3
Alpha-actinin-3

2

4

High-throughput

0.553

High

1066017

VAC14
Protein VAC14 homolog

2

4

High-throughput

0.553

High

1186600

KRA61
Keratin-associated protein 6-1

2

2

High-throughput

0.553

High

1186701

KRA62
Keratin-associated protein 6-2

2

1

High-throughput

0.553

High

1186912

KR195
Keratin-associated protein 19-5

2

1

High-throughput

0.553

High

1187918

KR197
Keratin-associated protein 19-7

2

1

High-throughput

0.553

High

1295373

GPSM1
G-protein-signaling modulator 1

2

7

High-throughput

0.553

High

1307093

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

1324484

AN36B
Ankyrin repeat domain-containing protein 36B

2

6

High-throughput

0.553

High

1386461

PKHB2
Pleckstrin homology domain-containing family B member 2

2

1

High-throughput

0.553

High

211414

RFOX2
RNA binding protein fox-1 homolog 2

1

4

Small-scale

0.541

High

685717

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

Small-scale

0.541

High

1010454

GPSM2
G-protein-signaling modulator 2

1

8

Small-scale

0.541

High

1229860

CYTSA
Cytospin-A

1

4

Small-scale

0.541

High

1419618

SYF1
Pre-mRNA-splicing factor SYF1

1

4

Small-scale

0.541

High

323053

WDR47
WD repeat-containing protein 47

1

6

High-throughput

0.536

High

1123098

FHL2
Four and a half LIM domains protein 2

1

13

High-throughput

0.536

High

1419619

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

2

High-throughput

0.536

High

1245296

Q6PJH3
A kinase

1

1

High-throughput

0.515

High

179740

MDM4
Protein Mdm4

1

2

High-throughput

0.501

High

373081

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.501

High

411037

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.501

High

472125

MET
Hepatocyte growth factor receptor

1

4

High-throughput

0.501

High

474262

NFIC
Nuclear factor 1 C-type

1

14

High-throughput

0.501

High

521431

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.501

High

667010

CCNE1
G1/S-specific cyclin-E1

1

2

High-throughput

0.501

High

687504

PTBP1
Polypyrimidine tract-binding protein 1

1

6

High-throughput

0.501

High

693361

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

2

High-throughput

0.501

High

718842

CCND2
G1/S-specific cyclin-D2

1

2

High-throughput

0.501

High

767325

MERL
Merlin

1

6

High-throughput

0.501

High

833584

SOX3
Transcription factor SOX-3

1

18

High-throughput

0.501

High

839081

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.501

High

842855

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

High-throughput

0.501

High

842930

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

4

High-throughput

0.501

High

1028379

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.501

High

1150251

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.501

High

1161384

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

High-throughput

0.501

High

1419514

NSD3
Histone-lysine N-methyltransferase NSD3

1

4

High-throughput

0.501

High

1419621

RASF1
Ras association domain-containing protein 1

1

1

High-throughput

0.501

High

1419627

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.501

High

255867

USO1
General vesicular transport factor p115

1

4

High-throughput

0.489

High

922496

CLH2
Clathrin heavy chain 2

1

1

High-throughput

0.489

High

1419623

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

1

High-throughput

0.489

High

1364986

TSC1
Hamartin

1

11

High-throughput

0.481

High

162968

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

571200

HGF
Hepatocyte growth factor

1

0

High-throughput

0.480

High

1126752

BECN1
Beclin-1

1

0

High-throughput

0.480

High

1419626

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.480

High

714404

PML
Protein PML

1

20

Small-scale

0.479

High

1017670

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

1292930

Q86WV8
TSC complex subunit 1

1

4

High-throughput

0.470

High

1394300

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.460

High

648655

FGFR4
Fibroblast growth factor receptor 4

1

12

High-throughput

0.457

High

710467

EPHA2
Ephrin type-A receptor 2

1

9

High-throughput

0.457

High

1103364

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

1017743

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

1408529

AKAP9
A-kinase anchor protein 9

1

4

High-throughput

0.439

High

1278897

KR193
Keratin-associated protein 19-3

2

0

High-throughput

0.316

High

591360

CD44
CD44 antigen

1

0

High-throughput

0.261

Low

1339338

BBS1
BBSome complex member BBS1

1

0

Small-scale

0.249

Low

1416751

BBS2
BBSome complex member BBS2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025