HitPredict

Interactor 1: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	14623875
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 272 Hs			1 763
+	Hs
		992764 SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		993712 SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028543 SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028900 SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1044115 RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1031320 PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		516508 PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		951958 SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		681823 SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	At
		621700 RB45A_ARATH (2-108): 1.34e-17: 83.6: 13.76		CDKA1_ARATH (156-482): 1.46e-122: 370: 26.65
+	Sc
		376610 PABP_YEAST (86-192): 7.08e-15: 75.9: 19.64		YAK1_YEAST (19-586): 3.53e-116: 371: 29.05
+	Hs
		625590 RBM4_HUMAN (3-122): 5.32e-17: 81.7: 22.50		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		516362 PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Zm
		33400 A0A1D6M1U3_MAIZE (2-184): 1.23e-65: 210: 34.20		A0A1D6L2E7_MAIZE (129-479): 1.14e-46: 181: 33.24
+	At
		847173 SRS31_ARATH (6-267): 2.4e-48: 162: 27.24		AFC3_ARATH (129-483): 3.59e-56: 199: 32.90
+	At
		51039 RSZ33_ARATH (5-80): 2.24e-13: 70.5: 51.32		A1L4Y9_ARATH (129-483): 3.59e-56: 199: 32.90
+	At
		847177 RSZ33_ARATH (5-80): 2.24e-13: 70.5: 51.32		AFC3_ARATH (129-483): 3.59e-56: 199: 32.90