HitPredict

Interactor 1: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Interactor 2: LARP1 (Q6PKG0)
La-related protein 1 (La ribonucleoprotein domain family member 1)
Gene: LARP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	24981860, 35271311, 37070251
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 1096
+	Hs
		516561 PABP1_HUMAN (1-644): 0: 542: 74.54		LARP1_HUMAN (1-1096): 0: 747: 100.00
+	Hs
		516553 PABP1_HUMAN (1-644): 0: 542: 74.54		LAR1B_HUMAN (175-1093): 0: 632: 55.38
+	Hs
		1031352 PABP4_HUMAN (1-644): 0: 585: 100.00		LARP7_HUMAN (399-925): 2.04e-79: 273: 15.37
+	Hs
		403212 PABP4_HUMAN (1-644): 0: 585: 100.00		LA_HUMAN (400-800): 4.26e-76: 258: 17.43
+	Hs
		516541 PABP1_HUMAN (1-644): 0: 542: 74.54		LARP7_HUMAN (399-925): 2.04e-79: 273: 15.37
+	Hs
		1116542 PABP3_HUMAN (1-644): 7.04e-175: 513: 68.98		LARP7_HUMAN (399-925): 2.04e-79: 273: 15.37
+	Hs
		1116304 PAP1L_HUMAN (1-636): 6.79e-165: 487: 63.89		LARP7_HUMAN (399-925): 2.04e-79: 273: 15.37
+	Hs
		1031407 PABP4_HUMAN (1-644): 0: 585: 100.00		LAR4B_HUMAN (274-867): 1.43e-32: 138: 13.23
+	Hs
		516568 PABP1_HUMAN (1-644): 0: 542: 74.54		LARP4_HUMAN (309-860): 6.21e-41: 164: 13.73
+	Hs
		516616 PABP1_HUMAN (1-644): 0: 542: 74.54		LAR4B_HUMAN (274-867): 1.43e-32: 138: 13.23
+	At
		285476 PABP2_ARATH (2-451): 5.23e-66: 230: 24.09		LRP6B_ARATH (205-638): 1.18e-43: 169: 16.06
+	Sc
		376965 PABP_YEAST (2-290): 4.28e-66: 228: 30.07		SLF1_YEAST (165-538): 9.2e-45: 170: 17.19
+	At
		285478 PABP8_ARATH (2-477): 3.37e-64: 225: 26.11		LRP6B_ARATH (205-638): 1.18e-43: 169: 16.06
+	At
		790116 PABP2_ARATH (2-451): 5.23e-66: 230: 24.09		LRP6C_ARATH (357-612): 7.01e-39: 153: 16.67
+	Hs
		582322 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		LARP7_HUMAN (399-925): 2.04e-79: 273: 15.37
+	Sc
		376709 PABP_YEAST (2-290): 4.28e-66: 228: 30.07		LHP1_YEAST (379-642): 1.05e-32: 130: 16.13
+	Hs
		403080 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		LA_HUMAN (400-800): 4.26e-76: 258: 17.43
+	Dm
		597071 PABP_DROME (2-464): 6.23e-64: 224: 22.09		LARP_DROME (208-614): 1.22e-25: 117: 23.40
+	Sc
		376650 PABP_YEAST (2-290): 4.28e-66: 228: 30.07		SRO9_YEAST (183-463): 1.89e-23: 106: 15.92
+	Hs
		474033 PAB4L_HUMAN (192-380): 4.58e-38: 146: 31.05		LAR4B_HUMAN (274-867): 1.43e-32: 138: 13.23