Protein: DSC2
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)

Gene: DSC2
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q02487

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005886 - plasma membrane
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036977

DSG2
Desmoglein-2

2

18

Small-scale

0.768

High

567834

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.691

High

1037019

CLC2B
C-type lectin domain family 2 member B

1

12

High-throughput

0.691

High

1037040

SIRPD
Signal-regulatory protein delta

1

2

High-throughput

0.691

High

1037055

BTNL2
Butyrophilin-like protein 2

1

7

High-throughput

0.691

High

1036988

CC50B
Cell cycle control protein 50B

2

3

High-throughput

0.628

High

1037033

PKP2
Plakophilin-2

1

20

Small-scale

0.621

High

1037059

PKP3
Plakophilin-3

1

20

Small-scale

0.621

High

1036987

CEA21
Cell adhesion molecule CEACAM21

1

6

High-throughput

0.618

High

1037057

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

7

High-throughput

0.618

High

577720

PLAK
Junction plakoglobin

1

20

Small-scale

0.618

High

1004035

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.618

High

1036706

DSG1
Desmoglein-1

1

17

Small-scale

0.618

High

1037027

GMCL1
Germ cell-less protein-like 1

3

6

High-throughput

0.609

High

373891

RASN
GTPase NRas

2

20

High-throughput

0.584

High

375426

RASK
GTPase KRas

2

20

High-throughput

0.584

High

540409

LAMP1
Lysosome-associated membrane glycoprotein 1

2

6

High-throughput

0.584

High

603939

CXA1
Gap junction alpha-1 protein

2

6

Small-scale

0.584

High

710185

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.584

High

761207

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.584

High

976214

RB11A
Ras-related protein Rab-11A

2

7

High-throughput

0.584

High

977947

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

296610

TNF13
Tumor necrosis factor ligand superfamily member 13

1

1

High-throughput

0.536

High

438879

CD1A
T-cell surface glycoprotein CD1a

1

5

High-throughput

0.536

High

602776

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

1030152

IL5RA
Interleukin-5 receptor subunit alpha

1

20

High-throughput

0.536

High

1037005

CERS3
Ceramide synthase 3

1

1

High-throughput

0.536

High

1037009

NRSN1
Neurensin-1

1

2

High-throughput

0.536

High

1037011

LIRA3
Leukocyte immunoglobulin-like receptor subfamily A member 3

1

3

High-throughput

0.536

High

1037013

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.536

High

1037018

ZDH19
Palmitoyltransferase ZDHHC19

1

7

High-throughput

0.536

High

1037032

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

10

High-throughput

0.536

High

1037036

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.536

High

1037046

SDF2L
Stromal cell-derived factor 2-like protein 1

1

5

High-throughput

0.536

High

1037056

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

259817

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.533

High

674140

BRD2
Bromodomain-containing protein 2

2

6

High-throughput

0.533

High

506838

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

933169

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

1037023

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

625322

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.489

High

663542

CMA1
Chymase

1

7

High-throughput

0.489

High

1036990

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.489

High

1037017

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

3

High-throughput

0.489

High

1037025

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.489

High

1037037

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.489

High

1037041

KLK15
Kallikrein-15

1

6

High-throughput

0.489

High

1037048

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.489

High

1037058

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

126556

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

154475

CLD4
Claudin-4

1

1

Small-scale

0.479

High

173901

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

9

High-throughput

0.479

High

189521

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

225999

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

299157

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

341030

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.479

High

363154

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

374538

RASH
GTPase HRas

1

20

High-throughput

0.479

High

411765

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

417387

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

418075

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.479

High

440034

LCK
Tyrosine-protein kinase Lck

1

13

High-throughput

0.479

High

463464

LYN
Tyrosine-protein kinase Lyn

1

14

High-throughput

0.479

High

466211

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

560370

IFM1
Interferon-induced transmembrane protein 1

1

4

High-throughput

0.479

High

562006

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

580999

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

587629

DESP
Desmoplakin

1

12

Small-scale

0.479

High

601246

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

631175

RAB5A
Ras-related protein Rab-5A

1

9

High-throughput

0.479

High

642810

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

657538

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.479

High

690921

1433T
14-3-3 protein theta

1

18

High-throughput

0.479

High

711870

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

715549

MARCS
Myristoylated alanine-rich C-kinase substrate

1

8

High-throughput

0.479

High

729760

1433B
14-3-3 protein beta/alpha

1

18

High-throughput

0.479

High

730524

1433S
14-3-3 protein sigma

1

18

High-throughput

0.479

High

880522

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

886263

ARL4D
ADP-ribosylation factor-like protein 4D

1

19

High-throughput

0.479

High

894691

EMD
Emerin

1

2

High-throughput

0.479

High

901775

RAB9A
Ras-related protein Rab-9A

1

14

High-throughput

0.479

High

910018

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

931836

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.479

High

932055

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.479

High

936303

AFAD
Afadin

1

10

High-throughput

0.479

High

941774

ARL4C
ADP-ribosylation factor-like protein 4C

1

16

High-throughput

0.479

High

944978

RAB25
Ras-related protein Rab-25

1

8

High-throughput

0.479

High

951104

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

953401

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955074

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956259

RAB2A
Ras-related protein Rab-2A

1

11

High-throughput

0.479

High

961968

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962714

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

966210

1433G
14-3-3 protein gamma

1

18

High-throughput

0.479

High

971422

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

974993

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

988295

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

990118

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.479

High

1015377

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1036973

CAV1
Caveolin-1

1

5

High-throughput

0.479

High

1036974

1433F
14-3-3 protein eta

1

18

High-throughput

0.479

High

1036976

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1036981

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

1036982

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.479

High

1036983

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1036985

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1036986

OCLN
Occludin

1

3

High-throughput

0.479

High

1036994

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1036995

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.479

High

1036999

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1037002

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1037003

TM11B
Transmembrane protease serine 11B

1

12

High-throughput

0.479

High

1037010

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

1037015

DHB11
Estradiol 17-beta-dehydrogenase 11

1

14

High-throughput

0.479

High

1037021

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1037022

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

1037024

LRC59
Leucine-rich repeat-containing protein 59

1

7

High-throughput

0.479

High

1037028

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1037030

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1037031

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

1037034

DERL1
Derlin-1

1

3

High-throughput

0.479

High

1037042

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1037043

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1037044

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1037045

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1037049

TMPS4
Transmembrane protease serine 4

1

11

High-throughput

0.479

High

1037052

ANFY1
Rabankyrin-5

1

2

High-throughput

0.479

High

889399

CLK1
Dual specificity protein kinase CLK1

1

4

High-throughput

0.457

High

261155

NSMA
Sphingomyelin phosphodiesterase 2

1

6

High-throughput

0.445

High

388397

B3AT
Band 3 anion transport protein

1

4

High-throughput

0.445

High

839452

PI4KA
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.445

High

1036975

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.445

High

1036979

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.445

High

1036984

UT2
Urea transporter 2

1

1

High-throughput

0.445

High

1036992

S39AC
Zinc transporter ZIP12

1

9

High-throughput

0.445

High

1037000

OLFM4
Olfactomedin-4

1

3

High-throughput

0.445

High

1037007

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

13

High-throughput

0.445

High

1037016

ZNT7
Zinc transporter 7

1

13

High-throughput

0.445

High

1037020

S39A7
Zinc transporter SLC39A7

1

9

High-throughput

0.445

High

1037039

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

139850

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

180791

TIF1A
Transcription intermediary factor 1-alpha

1

13

High-throughput

0.437

High

291302

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

327230

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

872224

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.437

High

1036980

BRD3
Bromodomain-containing protein 3

1

5

High-throughput

0.437

High

1036989

AR13B
ADP-ribosylation factor-like protein 13B

1

12

High-throughput

0.437

High

1036991

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.437

High

1036997

BRWD3
Bromodomain and WD repeat-containing protein 3

1

7

High-throughput

0.437

High

1037004

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1037006

DEN6A
Protein DENND6A

1

1

High-throughput

0.437

High

1037047

E41LA
Band 4.1-like protein 4A

1

16

High-throughput

0.437

High

1037050

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.437

High

1037051

TM216
Transmembrane protein 216

1

1

High-throughput

0.437

High

1037053

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.437

High

880832

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

841162

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

911555

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.407

High

943511

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

5

High-throughput

0.407

High

1036993

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

1036996

ZNT6
Zinc transporter 6

1

13

High-throughput

0.407

High

1037012

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

6

High-throughput

0.407

High

1037035

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.407

High

1037038

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

1037029

TAFA4
Chemokine-like protein TAFA-4

2

0

High-throughput

0.328

High

1036978

EP3A
Epididymal secretory protein E3-alpha

1

0

High-throughput

0.279

Low

1036998

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.279

Low

1037008

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low

1037026

SKA1
SKA complex subunit 1

1

0

High-throughput

0.279

Low

1037014

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1037001

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1037054

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025