Protein: DSC3
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)

Gene: DSC3
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q14574

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0001701 - in utero embryonic development
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1128566

PKP3
Plakophilin-3

1

20

Small-scale

0.713

High

1128564

CLC4A
C-type lectin domain family 4 member A

1

8

High-throughput

0.691

High

1128514

CC50B
Cell cycle control protein 50B

2

1

High-throughput

0.628

High

1128544

PKP4
Plakophilin-4

1

20

Small-scale

0.621

High

556082

CADH1
Cadherin-1

1

19

High-throughput

0.618

High

577757

PLAK
Junction plakoglobin

1

20

Small-scale

0.618

High

764751

CTNB1
Catenin beta-1

1

20

Small-scale

0.618

High

1128539

CLC4D
C-type lectin domain family 4 member D

1

8

High-throughput

0.618

High

1128563

CLC4E
C-type lectin domain family 4 member E

1

8

High-throughput

0.618

High

761225

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.594

High

540454

LAMP1
Lysosome-associated membrane glycoprotein 1

2

6

High-throughput

0.588

High

374601

RASH
GTPase HRas

2

19

High-throughput

0.584

High

463093

YES
Tyrosine-protein kinase Yes

1

14

High-throughput

0.536

High

472062

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.536

High

698657

CALX
Calnexin

1

5

High-throughput

0.536

High

733350

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

922814

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

5

High-throughput

0.536

High

930310

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

1

High-throughput

0.536

High

1128511

MK06
Mitogen-activated protein kinase 6

1

7

High-throughput

0.536

High

1128529

CDKL3
Cyclin-dependent kinase-like 3

1

8

High-throughput

0.536

High

1128530

TEX14
Inactive serine/threonine-protein kinase TEX14

1

20

High-throughput

0.536

High

1128532

NRSN1
Neurensin-1

1

2

High-throughput

0.536

High

1128545

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.536

High

1128555

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.536

High

1128561

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

1

High-throughput

0.536

High

1128565

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

188885

TMPS2
Transmembrane protease serine 2

1

11

High-throughput

0.515

High

692963

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

1128526

TM11B
Transmembrane protease serine 11B

1

12

High-throughput

0.515

High

1128557

TMPS4
Transmembrane protease serine 4

1

11

High-throughput

0.515

High

722785

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

1128542

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.513

High

1128567

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.501

High

439733

INSR
Insulin receptor

1

20

High-throughput

0.500

High

465521

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.500

High

1055048

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

20

High-throughput

0.500

High

1128510

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.500

High

1128512

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.500

High

939493

FCGRN
IgG receptor FcRn large subunit p51

1

3

High-throughput

0.489

High

1128513

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

1128527

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.489

High

1128537

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

3

High-throughput

0.489

High

1128538

ZDH19
Palmitoyltransferase ZDHHC19

1

6

High-throughput

0.489

High

157374

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

189566

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

327262

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

373931

RASN
GTPase NRas

1

20

High-throughput

0.479

High

375521

RASK
GTPase KRas

1

20

High-throughput

0.479

High

413828

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

460819

CATB
Cathepsin B

1

3

High-throughput

0.479

High

537160

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

541487

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

560392

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

572926

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.479

High

601290

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

642869

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

657573

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.479

High

658884

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

20

High-throughput

0.479

High

710242

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.479

High

872322

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

888065

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

910051

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

955171

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962048

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

978009

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

990221

1433Z
14-3-3 protein zeta/delta

1

18

Small-scale

0.479

High

1031370

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

1041066

CAV1
Caveolin-1

1

5

High-throughput

0.479

High

1087110

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1114817

CUL4A
Cullin-4A

1

5

High-throughput

0.479

High

1118019

DX39B
Spliceosome RNA helicase DDX39B

1

7

High-throughput

0.479

High

1128508

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1128519

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1128523

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1128524

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1128525

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1128533

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

1128540

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1128543

RANB9
Ran-binding protein 9

1

5

Small-scale

0.479

High

1128549

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1128550

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1128551

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1128552

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1128553

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1128556

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1128558

OTULL
Inactive ubiquitin thioesterase OTULINL

1

2

High-throughput

0.479

High

1128559

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1128560

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1128509

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.470

High

459288

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

580629

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

986428

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

388412

B3AT
Band 3 anion transport protein

1

4

High-throughput

0.445

High

841175

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.445

High

943517

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

5

High-throughput

0.445

High

1063044

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.445

High

1128515

S39AC
Zinc transporter ZIP12

1

7

High-throughput

0.445

High

1128516

NTCP5
Sodium/bile acid cotransporter 5

1

2

High-throughput

0.445

High

1128517

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1128521

S39A5
Zinc transporter ZIP5

1

7

High-throughput

0.445

High

1128528

SL9A9
Sodium/hydrogen exchanger 9

1

2

High-throughput

0.445

High

1128531

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

11

High-throughput

0.445

High

1128534

POC5
Centrosomal protein POC5

1

2

Small-scale

0.445

High

1128535

ZNT7
Zinc transporter 7

1

11

High-throughput

0.445

High

1128536

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

11

High-throughput

0.445

High

1128562

S39AA
Zinc transporter ZIP10

1

7

High-throughput

0.445

High

372027

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.437

High

970497

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1128507

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.437

High

1128541

ESR2
Estrogen receptor beta

1

9

High-throughput

0.437

High

1128547

RNF38
E3 ubiquitin-protein ligase RNF38

1

5

Small-scale

0.437

High

1128548

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1128554

ANLN
Anillin

1

5

High-throughput

0.437

High

1128518

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.407

High

1128520

ZNT6
Zinc transporter 6

1

11

High-throughput

0.407

High

1128546

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

185195

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.279

Low

1125309

FASTK
Fas-activated serine/threonine kinase

1

0

High-throughput

0.279

Low

1128522

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025