HitPredict

Interactor 1: IKZF1 (Q13422)
DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Gene: IKZF1

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12015313
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 1122
+	Hs
		880715 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		1033686 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1356565 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1329659 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1356578 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1033633 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1033690 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		177285 IKZF1_HUMAN (1-519): 0: 664: 100.00		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		880848 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880822 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880849 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		1260190 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1260200 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1038804 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1270517 IKZF2_HUMAN (37-517): 1.17e-145: 430: 53.74		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		1270436 IKZF4_HUMAN (28-515): 2.23e-142: 423: 51.26		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		1038805 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1270518 IKZF3_HUMAN (11-515): 4.42e-139: 413: 53.82		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Mm
		140300 Q8C5P6_MOUSE (1-254): 8.48e-111: 331: 94.88		HDAC1_MOUSE (673-1103): 1.61e-153: 468: 21.16
+	Mm
		936415 Q8C5P6_MOUSE (1-254): 8.48e-111: 331: 94.88		HDAC2_MOUSE (680-1113): 4.65e-153: 467: 21.68