Protein: PO2F1
POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1)

Gene: PO2F1, POU2F1
Organism: Homo sapiens
Interactions: 162
UniProt ID: P14859

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

576150

PO2F1
POU domain, class 2, transcription factor 1

5

18

Small-scale

0.918

High

576235

OBF1
POU domain class 2-associating factor 1

4

1

Small-scale

0.871

High

576210

PO6F2
POU domain, class 6, transcription factor 2

2

19

High-throughput

0.783

High

576234

ZFHX3
Zinc finger homeobox protein 3

2

10

High-throughput

0.783

High

576187

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.754

High

478311

HXC4
Homeobox protein Hox-C4

1

20

Small-scale

0.724

High

226511

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.698

High

576171

HXC9
Homeobox protein Hox-C9

1

20

High-throughput

0.698

High

576251

HXB13
Homeobox protein Hox-B13

1

20

High-throughput

0.698

High

403793

GCR
Glucocorticoid receptor

4

20

Small-scale

0.698

High

557825

XRCC6
X-ray repair cross-complementing protein 6

4

5

Small-scale

0.692

High

464784

SP1
Transcription factor Sp1

3

9

Small-scale

0.689

High

576182

PBX1
Pre-B-cell leukemia transcription factor 1

1

5

Small-scale

0.681

High

576196

PKNX1
Homeobox protein PKNOX1

1

6

Small-scale

0.681

High

559203

XRCC5
X-ray repair cross-complementing protein 5

4

5

Small-scale

0.676

High

576218

SP4
Transcription factor Sp4

3

9

High-throughput

0.675

High

576186

MAGAA
Melanoma-associated antigen 10

3

2

High-throughput

0.667

High

576269

NCOR2
Nuclear receptor corepressor 2

3

14

Small-scale

0.664

High

576191

HCFC1
Host cell factor 1

3

2

Small-scale

0.650

High

576180

BRCA1
Breast cancer type 1 susceptibility protein

3

2

Small-scale

0.640

High

387782

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.628

High

209948

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.618

High

224933

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.618

High

239919

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.618

High

418814

H2A1B
Histone H2A type 1-B/E

1

1

Small-scale

0.618

High

576166

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.618

High

576168

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.618

High

576178

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.618

High

576179

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.618

High

576197

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.618

High

576208

H31
Histone H3.1

1

9

High-throughput

0.618

High

576212

H33
Histone H3.3

1

9

High-throughput

0.618

High

576264

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.618

High

345145

ZMYM6
Zinc finger MYM-type protein 6

2

3

High-throughput

0.606

High

576165

NFYA
Nuclear transcription factor Y subunit alpha

2

1

High-throughput

0.606

High

576188

ARRB1
Beta-arrestin-1

2

1

High-throughput

0.606

High

576195

AF10
Protein AF-10

2

4

High-throughput

0.606

High

576220

CREM
cAMP-responsive element modulator

2

4

High-throughput

0.606

High

576159

RXRA
Retinoic acid receptor RXR-alpha

2

20

Small-scale

0.602

High

576211

PRKDC
DNA-dependent protein kinase catalytic subunit

2

5

Small-scale

0.602

High

395425

ESR1
Estrogen receptor

2

20

Small-scale

0.595

High

576160

TBP
TATA-box-binding protein

1

4

Small-scale

0.589

High

576215

PR20A
Proline-rich protein 20A

3

4

High-throughput

0.586

High

285577

BAF
Barrier-to-autointegration factor

2

0

Small-scale

0.585

High

473763

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

576161

LMNB1
Lamin-B1

2

5

Small-scale

0.584

High

576230

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

179455

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.580

High

576241

STOX1
Storkhead-box protein 1

2

0

High-throughput

0.580

High

576248

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.580

High

576254

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

576237

SNPC4
snRNA-activating protein complex subunit 4

2

4

Small-scale

0.576

High

576244

POGZ
Pogo transposable element with ZNF domain

1

4

High-throughput

0.573

High

576263

PLK3
Serine/threonine-protein kinase PLK3

1

4

High-throughput

0.573

High

377944

TNFA
Tumor necrosis factor

2

0

Small-scale

0.569

High

408650

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.561

High

522804

COT1
COUP transcription factor 1

1

20

Small-scale

0.561

High

576153

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

Small-scale

0.561

High

576221

TF65
Transcription factor p65

1

7

Small-scale

0.561

High

213561

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

2

1

High-throughput

0.553

High

486911

PARP1
Poly [ADP-ribose] polymerase 1

1

10

Small-scale

0.549

High

576217

IRF9
Interferon regulatory factor 9

1

4

High-throughput

0.541

High

576233

CEBPE
CCAAT/enhancer-binding protein epsilon

1

13

High-throughput

0.541

High

576155

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

Small-scale

0.536

High

133934

IPO5
Importin-5

1

3

High-throughput

0.536

High

221913

FOXS1
Forkhead box protein S1

1

15

High-throughput

0.536

High

536420

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.536

High

576174

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

576194

HSP72
Heat shock-related 70 kDa protein 2

1

3

High-throughput

0.536

High

576231

TEAD2
Transcriptional enhancer factor TEF-4

1

5

High-throughput

0.536

High

576255

PASK
PAS domain-containing serine/threonine-protein kinase

1

1

High-throughput

0.536

High

576259

FOXC2
Forkhead box protein C2

1

19

High-throughput

0.536

High

576193

MAT1
CDK-activating kinase assembly factor MAT1

1

2

Small-scale

0.527

High

576167

CCND1
G1/S-specific cyclin-D1

1

2

Small-scale

0.515

High

576245

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

576258

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

576213

PR20E
Proline-rich protein 20E

2

4

High-throughput

0.504

High

421431

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

442866

PRGR
Progesterone receptor

1

20

Small-scale

0.501

High

519707

ANDR
Androgen receptor

1

20

Small-scale

0.501

High

520506

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.501

High

533243

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.501

High

543454

VDR
Vitamin D3 receptor

1

20

Small-scale

0.501

High

576156

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.501

High

576169

TEAD1
Transcriptional enhancer factor TEF-1

1

5

Small-scale

0.501

High

576236

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

1

Small-scale

0.501

High

346833

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

576170

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

576152

ZEP1
Zinc finger protein 40

1

7

High-throughput

0.481

High

576205

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.481

High

142812

NFIB
Nuclear factor 1 B-type

1

16

High-throughput

0.479

High

162452

ANM5
Protein arginine N-methyltransferase 5

1

2

Small-scale

0.479

High

339644

KLF8
Krueppel-like factor 8

1

12

High-throughput

0.479

High

437079

K2C8
Keratin, type II cytoskeletal 8

1

3

Small-scale

0.479

High

443646

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

Small-scale

0.479

High

461102

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

463310

LYN
Tyrosine-protein kinase Lyn

1

5

Small-scale

0.479

High

534582

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.479

High

563119

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

Small-scale

0.479

High

572969

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

576151

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

9

Small-scale

0.479

High

576157

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

576158

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

Small-scale

0.479

High

576162

CD11B
Cyclin-dependent kinase 11B

1

5

Small-scale

0.479

High

576172

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

Small-scale

0.479

High

576173

STIP1
Stress-induced-phosphoprotein 1

1

2

Small-scale

0.479

High

576176

HSP74
Heat shock 70 kDa protein 4

1

3

Small-scale

0.479

High

576183

STAT3
Signal transducer and activator of transcription 3

1

5

Small-scale

0.479

High

576184

ELK3
ETS domain-containing protein Elk-3

1

14

High-throughput

0.479

High

576185

STA5A
Signal transducer and activator of transcription 5A

1

5

Small-scale

0.479

High

576189

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.479

High

576192

STA5B
Signal transducer and activator of transcription 5B

1

5

Small-scale

0.479

High

576199

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.479

High

576204

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

Small-scale

0.479

High

576206

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

576216

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.479

High

576219

PAX2
Paired box protein Pax-2

1

17

High-throughput

0.479

High

576223

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

576224

FOXC1
Forkhead box protein C1

1

17

High-throughput

0.479

High

576225

FOXL1
Forkhead box protein L1

1

16

High-throughput

0.479

High

576226

HDAC1
Histone deacetylase 1

1

4

Small-scale

0.479

High

576227

CUL3
Cullin-3

1

4

High-throughput

0.479

High

576229

IRF3
Interferon regulatory factor 3

1

4

Small-scale

0.479

High

576232

ELF2
ETS-related transcription factor Elf-2

1

12

High-throughput

0.479

High

576243

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

576247

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

Small-scale

0.479

High

576250

SP7
Transcription factor Sp7

1

11

High-throughput

0.479

High

576256

FEV
Protein FEV

1

11

High-throughput

0.479

High

576261

KLF16
Krueppel-like factor 16

1

10

High-throughput

0.479

High

576266

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

576268

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

576214

PR20D
Proline-rich protein 20D

1

4

High-throughput

0.470

High

576242

Q7KZS0
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.470

High

576154

EPCAM
Epithelial cell adhesion molecule

1

0

Small-scale

0.458

High

576181

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

576198

RL37A
Large ribosomal subunit protein eL43

1

0

Small-scale

0.458

High

576200

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.458

High

576201

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.458

High

576202

RS24
Small ribosomal subunit protein eS24

1

0

Small-scale

0.458

High

576203

RL31
Large ribosomal subunit protein eL31

1

0

Small-scale

0.458

High

576228

NPAT
Protein NPAT

1

0

Small-scale

0.458

High

576249

FBX25
F-box only protein 25

1

0

Small-scale

0.458

High

576252

EAF2
ELL-associated factor 2

1

0

Small-scale

0.458

High

576260

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

576265

PRR13
Proline-rich protein 13

1

0

Small-scale

0.458

High

576177

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

576175

CXCR5
C-X-C chemokine receptor type 5

1

3

Small-scale

0.437

High

576190

5NTC
Cytosolic purine 5'-nucleotidase

1

1

Small-scale

0.437

High

576207

TBA1B
Tubulin alpha-1B chain

1

4

Small-scale

0.437

High

576222

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.437

High

576238

FBW10
F-box/WD repeat-containing protein 10

1

4

High-throughput

0.437

High

576239

SCYL2
SCY1-like protein 2

1

3

Small-scale

0.437

High

576240

RL22L
Ribosomal protein eL22-like

1

1

Small-scale

0.437

High

576246

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.437

High

576253

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

Small-scale

0.437

High

576257

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

Small-scale

0.437

High

576267

SNX24
Sorting nexin-24

2

0

High-throughput

0.316

High

576164

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

576262

LOXE3
Hydroperoxide isomerase ALOXE3

1

0

High-throughput

0.279

Low

576163

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low

576209

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025