HitPredict

Interactor 1: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.50	0.622

Property	Details
Experiments	16374509, 18296648, 25825872
Identification Methods	pull down, affinity chromatography technology, phage display, peptide array, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 863 Hs			1 1133
+	Hs
		197606 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		1136544 ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00		SPD2A_HUMAN (1-1133): 5.76e-173: 541: 100.00
+	Hs
		1034763 ADA15_HUMAN (1-863): 0: 556: 100.00		SH3R3_HUMAN (384-1130): 4.05e-32: 137: 11.21
+	Hs
		1034753 ADA15_HUMAN (1-863): 0: 556: 100.00		ITSN1_HUMAN (765-1133): 1.87e-22: 106: 11.47
+	Hs
		557680 ADA15_HUMAN (1-863): 0: 556: 100.00		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		1034759 ADA15_HUMAN (1-863): 0: 556: 100.00		SH3R1_HUMAN (314-1130): 5.57e-18: 91.9: 8.98
+	Hs
		537642 ADA15_HUMAN (1-863): 0: 556: 100.00		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50
+	Hs
		1034750 ADA15_HUMAN (1-863): 0: 556: 100.00		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62
+	Hs
		197601 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		ITSN1_HUMAN (765-1133): 1.87e-22: 106: 11.47
+	Hs
		197604 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		SH319_HUMAN (139-558): 5.95e-22: 104: 12.62
+	Hs
		557788 ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		197624 ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32		ITSN2_HUMAN (58-295): 4.7e-15: 82.9: 11.77
+	Hs
		537641 ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50
+	Hs
		537670 ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50
+	Hs
		537623 ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50
+	Hs
		152249 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		152297 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		SH319_HUMAN (139-558): 5.95e-22: 104: 12.62
+	Hs
		152245 ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50