Protein: SFXN3
Sideroflexin-3

Gene: SFXN3
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q9BWM7

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006730 - one-carbon metabolic process
GO:0015075 - monoatomic ion transmembrane transporter activity
GO:0015194 - L-serine transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1416302

SCN3B
Sodium channel regulatory subunit beta-3

4

2

High-throughput

0.638

High

1416298

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

2

High-throughput

0.628

High

562370

LAMP2
Lysosome-associated membrane glycoprotein 2

3

3

High-throughput

0.613

High

1036245

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

1

High-throughput

0.609

High

1416311

TMX2
Thioredoxin-related transmembrane protein 2

2

1

High-throughput

0.606

High

469540

SYPH
Synaptophysin

2

2

High-throughput

0.574

High

564327

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.574

High

854576

S15A1
Solute carrier family 15 member 1

2

1

High-throughput

0.574

High

1181011

TR16L
Tripartite motif-containing protein 16-like protein

2

1

High-throughput

0.574

High

1359153

GLMP
Glycosylated lysosomal membrane protein

2

1

High-throughput

0.574

High

1416309

CLC4E
C-type lectin domain family 4 member E

2

1

High-throughput

0.574

High

1150694

TRBP2
RISC-loading complex subunit TARBP2

2

2

High-throughput

0.558

High

1109036

AQP6
Aquaporin-6

2

3

High-throughput

0.553

High

1279361

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

3

High-throughput

0.553

High

1333982

DHB11
Estradiol 17-beta-dehydrogenase 11

2

3

High-throughput

0.553

High

1398469

TLCD4
TLC domain-containing protein 4

2

1

High-throughput

0.553

High

1416292

REEP4
Receptor expression-enhancing protein 4

2

2

High-throughput

0.553

High

1416299

TM14B
Transmembrane protein 14B

2

2

High-throughput

0.553

High

1413861

THTPA
Thiamine-triphosphatase

2

1

High-throughput

0.549

High

220011

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

471223

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.536

High

774593

BASI
Basigin

1

6

High-throughput

0.536

High

788178

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

1280468

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.536

High

1350875

HUMMR
Protein MGARP

1

1

High-throughput

0.536

High

1416287

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.536

High

230422

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.526

High

1251682

T184A
Transmembrane protein 184A

1

0

High-throughput

0.513

High

154877

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

2

High-throughput

0.489

High

166033

FFAR1
Free fatty acid receptor 1

1

7

High-throughput

0.489

High

182757

GP182
G-protein coupled receptor 182

1

11

High-throughput

0.489

High

259085

DNJA2
DnaJ homolog subfamily A member 2

1

4

High-throughput

0.489

High

260945

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.489

High

268936

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

1

High-throughput

0.489

High

380348

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

4

High-throughput

0.489

High

488341

PPBI
Intestinal-type alkaline phosphatase

1

2

High-throughput

0.489

High

531999

PPBN
Alkaline phosphatase, germ cell type

1

2

High-throughput

0.489

High

575700

GPIX
Platelet glycoprotein IX

1

5

High-throughput

0.489

High

714396

PML
Protein PML

1

5

High-throughput

0.489

High

749383

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

2

High-throughput

0.489

High

754091

CD80
T-lymphocyte activation antigen CD80

1

2

High-throughput

0.489

High

771226

APJ
Apelin receptor

1

7

High-throughput

0.489

High

845123

EAA3
Excitatory amino acid transporter 3

1

3

High-throughput

0.489

High

873373

AL3B2
Aldehyde dehydrogenase family 3 member B2

1

3

High-throughput

0.489

High

1034814

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.489

High

1086097

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.489

High

1090111

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

4

High-throughput

0.489

High

1098934

KLRD1
Natural killer cells antigen CD94

1

4

High-throughput

0.489

High

1177875

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.489

High

1249775

TM108
Transmembrane protein 108

1

1

High-throughput

0.489

High

1254078

LRC55
Leucine-rich repeat-containing protein 55

1

3

High-throughput

0.489

High

1324856

LRC25
Leucine-rich repeat-containing protein 25

1

1

High-throughput

0.489

High

1336523

LRN4L
LRRN4 C-terminal-like protein

1

1

High-throughput

0.489

High

1363222

AQP3
Aquaporin-3

1

1

High-throughput

0.489

High

1407295

CML1
Chemerin-like receptor 1

1

6

High-throughput

0.489

High

1416310

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.489

High

1416314

NPTN
Neuroplastin

1

6

High-throughput

0.489

High

137806

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

2

High-throughput

0.479

High

283956

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

412550

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

1367176

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1416288

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

843939

HD
Huntingtin

1

3

High-throughput

0.470

High

1142934

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

1

High-throughput

0.470

High

133791

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

401421

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

1085617

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

1123

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

530319

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

847439

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

1271266

SV2B
Synaptic vesicle glycoprotein 2B

1

4

High-throughput

0.445

High

1416294

SFXN1
Sideroflexin-1

1

4

High-throughput

0.445

High

1416313

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

3

High-throughput

0.445

High

718728

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

1

High-throughput

0.439

High

157807

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

346275

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.437

High

349229

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.437

High

363808

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.437

High

373045

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

377715

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.437

High

537828

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

581263

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.437

High

589593

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

696404

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

769075

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

831363

CCNF
Cyclin-F

1

3

High-throughput

0.437

High

897384

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.437

High

905101

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

920256

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.437

High

955544

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.437

High

962437

RHOA
Transforming protein RhoA

1

7

High-throughput

0.437

High

978264

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.437

High

1101187

CLN3
Battenin

1

2

Small-scale

0.437

High

1107168

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

1115976

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.437

High

1151851

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.437

High

1163898

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.437

High

1229665

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

1252964

BAKOR
Beclin 1-associated autophagy-related key regulator

1

3

High-throughput

0.437

High

1255368

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1270971

RHOU
Rho-related GTP-binding protein RhoU

1

9

High-throughput

0.437

High

1326896

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.437

High

1330380

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

1412645

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.437

High

1416286

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

1416290

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.437

High

1416293

EXO5
Exonuclease V

1

1

Small-scale

0.437

High

1416295

RHOF
Rho-related GTP-binding protein RhoF

1

9

High-throughput

0.437

High

1416306

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

749636

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

0

High-throughput

0.426

High

1416305

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.426

High

935088

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.407

High

1208953

DCA10
DDB1- and CUL4-associated factor 10

1

1

High-throughput

0.407

High

1227385

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

1310941

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

1326071

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

1358956

DNJA4
DnaJ homolog subfamily A member 4

1

4

High-throughput

0.407

High

1416296

S39A2
Zinc transporter ZIP2

1

1

High-throughput

0.407

High

1142526

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.328

High

1416300

KTU
Protein kintoun

2

0

High-throughput

0.318

High

1416307

NUFP1
FMR1-interacting protein NUFIP1

2

0

High-throughput

0.318

High

329659

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

1291482

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.316

High

1392163

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

1416301

TMM51
Transmembrane protein 51

2

0

High-throughput

0.316

High

125050

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.279

Low

231339

EFNA2
Ephrin-A2

1

0

High-throughput

0.279

Low

320498

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

583941

KCNE1
Potassium voltage-gated channel subfamily E member 1

1

0

High-throughput

0.279

Low

683628

ITB7
Integrin beta-7

1

0

High-throughput

0.279

Low

848562

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

956228

RAB4B
Ras-related protein Rab-4B

1

0

High-throughput

0.279

Low

1104478

ILK
Scaffold protein ILK

1

0

High-throughput

0.279

Low

1117016

LAMB3
Laminin subunit beta-3

1

0

High-throughput

0.279

Low

1219990

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1287182

T150A
Transmembrane protein 150A

1

0

High-throughput

0.279

Low

1292406

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

1349107

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1351740

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.279

Low

1415031

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

1416291

CST9L
Cystatin-9-like

1

0

High-throughput

0.279

Low

1416308

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1398506

ZDH15
Palmitoyltransferase ZDHHC15

1

0

High-throughput

0.268

Low

1416312

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

284414

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.249

Low

415837

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.249

Low

583890

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.249

Low

1140790

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1246966

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1312426

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low

1339841

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

High-throughput

0.249

Low

1416289

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

1416297

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1416303

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

1416304

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.249

Low

1119289

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

1230804

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.232

Low

1279227

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.232

Low

1294057

MEX3D
RNA-binding protein MEX3D

1

0

High-throughput

0.232

Low

1339456

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025