Interactor 1: GCYB1 (Q02153)
Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
Gene: GUCY1B1
Interactor 2: GCYB1 (Q02153)
Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
Gene: GUCY1B1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.41 | 1.00 | 0.647 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23505436 |
| Identification Methods | x-ray crystallography |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Guanylate_cyc~Guanylate_cyc, Guanylate_cyc~HNOBA, HNOB~HNOB, HNOB~HNOBA, HNOBA~HNOBA |
| Common GO terms | GO:0004016 - adenylate cyclase activity GO:0004383 - guanylate cyclase activity GO:0005525 - GTP binding GO:0005829 - cytosol GO:0006182 - cGMP biosynthetic process and 16 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
