Protein: GCYA2
Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)

Gene: GCYA2, GUCY1A2
Organism: Homo sapiens
Interactions: 17
UniProt ID: P33402

Gene Ontology (top 5):
GO:0004383 - guanylate cyclase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0007263 - nitric oxide mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

752039

GCYB1
Guanylate cyclase soluble subunit beta-1

3

8

Small-scale

0.861

High

752038

DLG4
Disks large homolog 4

2

9

Small-scale

0.595

High

752040

DLG1
Disks large homolog 1

2

8

Small-scale

0.595

High

752043

SCRIB
Protein scribble homolog

2

10

Small-scale

0.567

High

752047

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.561

High

752041

SNTA1
Alpha-1-syntrophin

2

12

Small-scale

0.560

High

752046

ERBIN
Erbin

1

1

Small-scale

0.527

High

167679

LIN7A
Protein lin-7 homolog A

1

11

High-throughput

0.489

High

461195

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

752044

DLG2
Disks large homolog 2

1

8

Small-scale

0.479

High

752045

DLG3
Disks large homolog 3

1

8

Small-scale

0.479

High

295099

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.458

High

752037

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

752042

SNTB1
Beta-1-syntrophin

1

10

High-throughput

0.457

High

105444

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

192361

GSC2
Homeobox protein goosecoid-2

2

0

High-throughput

0.316

High

339210

SFT2B
Vesicle transport protein SFT2B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025