Protein: GCYA1
Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit)

Gene: GCYA1, GUCY1A1
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q02108

Gene Ontology (top 5):
GO:0004383 - guanylate cyclase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol
GO:0006182 - cGMP biosynthetic process
GO:0007263 - nitric oxide mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1034918

GCYB1
Guanylate cyclase soluble subunit beta-1

4

8

Small-scale

0.898

High

1034932

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

Small-scale

0.676

High

1034926

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

5

High-throughput

0.618

High

248692

PEPL
Periplakin

1

1

High-throughput

0.536

High

568142

PLSL
Plastin-2

1

1

High-throughput

0.536

High

713365

SPB3
Serpin B3

1

3

High-throughput

0.536

High

724560

S10A7
Protein S100-A7

1

1

High-throughput

0.536

High

874775

SPB4
Serpin B4

1

3

High-throughput

0.536

High

1034924

S1A7A
Protein S100-A7A

1

1

High-throughput

0.536

High

853652

MK08
Mitogen-activated protein kinase 8

1

0

High-throughput

0.518

High

1034933

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

126234

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

457855

INVO
Involucrin

1

0

High-throughput

0.513

High

483900

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

627124

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

711700

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.513

High

839542

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

868081

AL1A3
Retinaldehyde dehydrogenase 3

1

0

High-throughput

0.513

High

999340

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.513

High

1034925

PA24D
Cytosolic phospholipase A2 delta

1

0

High-throughput

0.513

High

212213

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.493

High

289252

SPB7
Serpin B7

1

3

High-throughput

0.489

High

787635

SPB5
Serpin B5

1

3

High-throughput

0.489

High

868674

LEG7
Galectin-7

1

7

High-throughput

0.489

High

945777

EPIPL
Epiplakin

1

1

High-throughput

0.489

High

1034931

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.479

High

413655

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

997652

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.458

High

1034919

IRF8
Interferon regulatory factor 8

1

0

Small-scale

0.458

High

1034928

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.458

High

1034929

CSN4
COP9 signalosome complex subunit 4

1

0

Small-scale

0.458

High

387964

FIBG
Fibrinogen gamma chain

1

0

High-throughput

0.279

Low

932335

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

1034920

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.279

Low

1034921

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

1034923

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

1034927

TMM40
Transmembrane protein 40

1

0

High-throughput

0.279

Low

1034930

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.279

Low

1034922

H37
Histone H3-7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025